|
1
|
(HPO:0001347)
|
Hyperreflexia |
|
|
|
|
363 / 7739
|
|
2
|
(HPO:0001761)
|
Pes cavus |
|
|
|
|
225 / 7739
|
|
3
|
(HPO:0002169)
|
Clonus |
Occasional [HPO:probinson]
|
|
|
|
37 / 7739
|
|
4
|
(HPO:0002355)
|
Difficulty walking |
|
|
|
|
61 / 7739
|
|
5
|
(HPO:0002366)
|
Abnormal lower motor neuron morphology |
|
|
|
|
12 / 7739
|
|
6
|
(HPO:0002398)
|
Degeneration of anterior horn cells |
|
|
|
|
14 / 7739
|
|
7
|
(HPO:0002460)
|
Distal muscle weakness |
|
|
|
|
122 / 7739
|
|
8
|
(HPO:0003405)
|
Diffuse axonal swelling |
|
|
|
|
1 / 7739
|
|
9
|
(HPO:0003487)
|
Babinski sign |
|
|
|
|
179 / 7739
|
|
10
|
(HPO:0006825)
|
Pallor of dorsal columns of the spinal cord |
|
|
|
|
1 / 7739
|
|
11
|
(HPO:0007354)
|
Amyotrophic lateral sclerosis |
|
|
|
|
25 / 7739
|
|
12
|
(OMIM)
|
Pes cavus has been reported |
|
|
|
|
1 / 7739
|
|
13
|
(OMIM)
|
Atrophy of distal muscles |
|
|
|
|
1 / 7739
|
|
14
|
(OMIM)
|
Proximal weakness occurs later |
|
|
|
|
1 / 7739
|
|
15
|
(HPO:0002127)
|
Abnormal upper motor neuron morphology |
|
|
|
|
15 / 7739
|
|
16
|
(OMIM)
|
Clonus may occur |
|
|
|
|
1 / 7739
|
|
17
|
(OMIM)
|
Corticospinal tracts with decreased myelin staining |
|
|
|
|
1 / 7739
|
|
18
|
(OMIM)
|
No bulbar involvement |
|
|
|
|
1 / 7739
|
|
19
|
(OMIM)
|
Axonal degeneration |
|
|
|
|
7 / 7739
|
|
20
|
(OMIM)
|
No sensory abnormalities |
|
|
|
|
5 / 7739
|
|
21
|
(HPO:0000006)
|
Autosomal dominant inheritance |
|
|
|
|
2518 / 7739
|
|
22
|
(HPO:0003677)
|
Slow progression |
|
|
|
|
134 / 7739
|
|
23
|
(HPO:0040078)
|
Axonal degeneration |
|
|
|
|
10 / 7739
|