Symptom Information: Sort according to HPO 

1
 (HPO:0000966) Hypohidrosis Frequent [IBIS] 25987173; 25232851; 25030479; 18596579; 19318041; 26179544; 25660182; 17657109; 19092368 IBIS 41 / 7739
2
 (HPO:0000093) Proteinuria Frequent [IBIS] Frequent [Orphanet] 25232851; 25030479; 18596579; 19318041; 26179544; 25977923; 17657109; 19092368; 16799480; 22431073 IBIS 169 / 7739
3
 (HPO:0001014) Angiokeratoma Frequent [IBIS] 25987173; 25232851; 25030479; 18596579; 19318041; 26179544; 25977923; 25660182; 17657109; 19092368; 9163848 IBIS 5 / 7739
4
 (HPO:0002014) Diarrhea Frequent [IBIS] 25987173; 25232851; 25030479; 18596579; 19318041; 17657109; 22431073 IBIS 225 / 7739
5
 (HPO:0003401) Paresthesia Frequent [IBIS] 25987173; 25232851; 25030479; 18596579; 26179544; 25660182; 17657109; 19092368; 22431073 IBIS 42 / 7739
6
 (OMIM) Neuropathic pain Frequent [IBIS] 25232851; 18596579; 17657109 IBIS 2 / 7739
7
 (HPO:0000531) Corneal crystals Frequent [IBIS] 25232851; 25030479; 19318041; 25660182; 17657109 IBIS 9 / 7739
8
 (HPO:0002019) Constipation Frequent [IBIS] 25232851; 17657109 IBIS 194 / 7739
9
 (HPO:0002013) Vomiting Occasional [IBIS] 25232851; 17657109 IBIS 191 / 7739
10
 (HPO:0000790) Hematuria Rare [IBIS] Very frequent [Orphanet] 17657109 IBIS 106 / 7739
11
 (HPO:0002039) Anorexia Rare [IBIS] Frequent [Orphanet] 2510982 IBIS 62 / 7739
12
 (HPO:0011276) Vascular skin abnormality Very frequent [Orphanet] 16403380 IBIS 24 / 7739
13
 (HPO:0000280) Coarse facial features Frequent [Orphanet] 19318041 IBIS 189 / 7739
14
 (HPO:0006536) Obstructive lung disease 17657109 IBIS 7 / 7739
15
 (HPO:0001903) Anemia Very frequent [Orphanet] 19318041 IBIS 289 / 7739
16
 (HPO:0004370) Abnormality of temperature regulation Very frequent [Orphanet] 25232851; 18596579 IBIS 58 / 7739
17
 (HPO:0011675) Arrhythmia Occasional [Orphanet] 25987173; 25030479; 18596579; 19318041; 25977923; 17657109; 19092368 IBIS 226 / 7739
18
 (HPO:0002027) Abdominal pain Very frequent [Orphanet] 25232851; 25030479; 18596579; 19318041; 25977923; 17657109; 22431073 IBIS 184 / 7739
19
 (HPO:0000100) Nephrotic syndrome Very frequent [Orphanet] 16799480 IBIS 83 / 7739
20
 (HPO:0003119) Abnormality of lipid metabolism Frequent [Orphanet] 9163848 IBIS 60 / 7739
21
 (HPO:0000822) Hypertension Occasional [Orphanet] 25030479; 17657109; 19092368; 9163848; 16799480 IBIS 224 / 7739
22
 (HPO:0001250) Seizures Occasional [Orphanet] 17657109 IBIS 1245 / 7739
23
 (HPO:0000083) Renal insufficiency Very frequent [Orphanet] 25987173; 25030479; 19318041; 26179544; 19092368; 9163848; 22431073 IBIS 232 / 7739
24
 (HPO:0001638) Cardiomyopathy Occasional [Orphanet] 17657109; 16799480 IBIS 192 / 7739
25
 (HPO:0001658) Myocardial infarction 25030479; 19092368; 19092368 IBIS 30 / 7739
26
 (HPO:0001681) Angina pectoris 25987173; 25030479; 19092368 IBIS 22 / 7739
27
 (HPO:0100585) Telangiectasia of the skin Very frequent [Orphanet] 19092368 IBIS 66 / 7739
28
 (HPO:0001297) Stroke 25987173; 19318041; 26179544; 17657109; 19092368; 22431073 IBIS 44 / 7739
29
 (HPO:0002140) Ischemic stroke Very frequent [Orphanet] 25030479; 19318041 IBIS 70 / 7739
30
 (HPO:0002326) Transient ischemic attack 25030479; 19318041; 17657109; 19092368 IBIS 13 / 7739
31
 (HPO:0000962) Hyperkeratosis Very frequent [Orphanet] 16403380 IBIS 216 / 7739
32
 (HPO:0000518) Cataract Frequent [Orphanet] 25660182; 17657109; 19092368 IBIS 454 / 7739
33
 (HPO:0000365) Hearing impairment Very frequent [Orphanet] 25660182; 17657109 IBIS 539 / 7739
34
 (HPO:0001004) Lymphedema Occasional [Orphanet] 19092368 IBIS 62 / 7739
35
 (HPO:0001635) Congestive heart failure Very frequent [Orphanet] 25987173; 25030479; 17657109; 19092368 IBIS 232 / 7739
36
 (HPO:0000124) Renal tubular dysfunction Frequent [Orphanet] 17657109 IBIS 46 / 7739
37
 (HPO:0002018) Nausea 25232851; 17657109 IBIS 44 / 7739
38
 (HPO:0001945) Fever Occasional [Orphanet] 25977923; 17657109 IBIS 218 / 7739
39
 (HPO:0001633) Abnormality of the mitral valve Frequent [Orphanet] 25030479; 19092368 IBIS 69 / 7739
40
 (HPO:0001646) Abnormality of the aortic valve Frequent [Orphanet] 25030479; 19092368 IBIS 55 / 7739
41
 (HPO:0001677) Coronary artery disease Occasional [Orphanet] 17657109 IBIS 58 / 7739
42
 (HPO:0001712) Left ventricular hypertrophy 25987173; 25232851; 25030479; 18596579; 17657109; 19092368; 22431073 IBIS 76 / 7739
43
 (HPO:0002459) Dysautonomia 25232851; 17657109 IBIS 34 / 7739
44
 (HPO:0003394) Muscle cramps 18596579 IBIS 106 / 7739
45
 (HPO:0100543) Cognitive impairment Occasional [Orphanet] 17657109 IBIS 230 / 7739
46
 (HPO:0011025) Abnormality of cardiovascular system physiology Frequent [Orphanet] 25987173 IBIS 41 / 7739
47
 (HPO:0000481) Abnormality of the cornea Very frequent [Orphanet] 17657109 IBIS 124 / 7739
48
 (HPO:0012471) Thick vermilion border Frequent [Orphanet] 19318041 IBIS 115 / 7739
49
 (HPO:0005157) Concentric hypertrophic cardiomyopathy 25987173 IBIS 5 / 7739
50
 (HPO:0001685) Myocardial fibrosis 25987173; 25030479 IBIS 30 / 7739
51
 (HPO:0009763) Limb pain 25987173; 25232851; 19318041 IBIS 7 / 7739
52
 (HPO:0012719) Functional abnormality of the gastrointestinal tract 25232851; 18596579; 25977923; 17657109; 19092368 IBIS 17 / 7739
53
 (HPO:0012841) Retinal vascular tortuosity 25232851; 17657109 IBIS 3 / 7739
54
 (HPO:0003546) Exercise intolerance 25232851; 25030479; 19318041; 17657109 IBIS 62 / 7739
55
 (HPO:0012531) Pain 25232851; 18596579; 17657109 IBIS 9 / 7739
56
 (MedDRA:10016825) Flushing 25232851 IBIS 2 / 7739
57
 (HPO:0002315) Headache 25232851 IBIS 175 / 7739
58
 (HPO:0012378) Fatigue 25232851; 17657109 IBIS 50 / 7739
59
 (MedDRA:10019345) Heat stroke 25232851 IBIS 1 / 7739
60
 (MedDRA:10072731) White matter lesion 25232851 IBIS 7 / 7739
61
 (HPO:0002500) Abnormality of the cerebral white matter 25232851 IBIS 73 / 7739
62
 (HPO:0005101) High-frequency hearing impairment 25232851 IBIS 16 / 7739
63
 (HPO:0000360) Tinnitus 25232851; 19318041; 25660182 IBIS 29 / 7739
64
 (HPO:0002321) Vertigo 25232851; 19318041; 25660182; 22431073 IBIS 58 / 7739
65
 (HPO:0002579) Gastrointestinal dysmotility 25232851 IBIS 11 / 7739
66
 (HPO:0100749) Chest pain 25232851; 19092368; 22431073 IBIS 92 / 7739
67
 (HPO:0001654) Abnormality of the heart valves 25232851; 18596579; 19318041; 17657109; 19092368 IBIS 49 / 7739
68
 (HPO:0000970) Anhidrosis 25232851; 17657109 IBIS 24 / 7739
69
 (HPO:0012213) Decreased glomerular filtration rate 25232851; 19318041; 26179544 IBIS 21 / 7739
70
 (HPO:0010872) EKG: T-wave inversion 25232851; 19092368 IBIS 19 / 7739
71
 (HPO:0001653) Mitral regurgitation 25232851; 17657109; 19092368 IBIS 64 / 7739
72
 (HPO:0005180) Tricuspid regurgitation 25232851 IBIS 20 / 7739
73
 (HPO:0012594) Microalbuminuria 25232851; 18596579 IBIS 6 / 7739
74
 (HPO:0001279) Syncope 25232851; 19092368 IBIS 94 / 7739
75
 (MedDRA:10034872) Phenylketonuria 25232851 IBIS 1 / 7739
76
 (MedDRA:10059186) Early satiety 25030479 IBIS 4 / 7739
77
 (HPO:0200128) Biventricular hypertrophy 25030479 IBIS 11 / 7739
78
 (HPO:0001659) Aortic regurgitation 25030479 IBIS 36 / 7739
79
 (HPO:0000096) Glomerulosclerosis 25030479; 26179544; 17657109; 16799480 IBIS 11 / 7739
80
 (HPO:0001977) Abnormal thrombosis 25030479 IBIS 11 / 7739
81
 (HPO:0000969) Edema 25030479 IBIS 117 / 7739
82
 (HPO:0030148) Heart murmur 25030479 IBIS 29 / 7739
83
 (HPO:0002094) Dyspnea 25030479; 25977923; 19092368 IBIS 132 / 7739
84
 (MedDRA:10052337) Diastolic dysfunction 25030479; 19318041 IBIS 14 / 7739
85
 (HPO:0430021) Abnormality of the common carotid artery 25030479 IBIS 2 / 7739
86
 (HPO:0012273) Increased carotid artery intimal medial thickness 25030479 IBIS 2 / 7739
87
 (HPO:0004755) Supraventricular tachycardia 25030479; 19318041 IBIS 20 / 7739
88
 (HPO:0001662) Bradycardia 25030479; 19318041 IBIS 41 / 7739
89
 (HPO:0004308) Ventricular arrhythmia 25030479; 19092368 IBIS 46 / 7739
90
 (HPO:0001645) Sudden cardiac death 25030479; 19092368 IBIS 84 / 7739
91
 (HPO:0003774) Stage 5 chronic kidney disease 25030479; 19318041; 26179544; 25977923; 17657109; 16799480 IBIS 78 / 7739
92
 (MedDRA:10070893) Globotriaosylceramide increased 25030479 IBIS 1 / 7739
93
 (HPO:0012532) Chronic pain 18596579 IBIS 3 / 7739
94
 (HPO:0001688) Sinus bradycardia 18596579 IBIS 18 / 7739
95
 (HPO:0012212) Abnormal glomerular filtration rate 18596579 IBIS 4 / 7739
96
 (HPO:0001071) Angiokeratoma corporis diffusum 19318041; 17657109; 16799480 IBIS 7 / 7739
97
 (HPO:0000629) Periorbital fullness 19318041 IBIS 13 / 7739
98
 (HPO:0009748) Large earlobe 19318041 IBIS 27 / 7739
99
 (HPO:0000574) Thick eyebrow 19318041 IBIS 96 / 7739
100
 (HPO:0000290) Abnormality of the forehead 19318041 IBIS 5 / 7739
101
 (OMIM) Recessed forehead 19318041 IBIS 2 / 7739
102
 (HPO:0000366) Abnormality of the nose 19318041 IBIS 56 / 7739
103
 (HPO:0000414) Bulbous nose 19318041 IBIS 63 / 7739
104
 (HPO:0000336) Prominent supraorbital ridges 19318041 IBIS 45 / 7739
105
 (HPO:0011800) Midface retrusion 19318041 IBIS 221 / 7739
106
 (HPO:0000426) Prominent nasal bridge 19318041 IBIS 121 / 7739
107
 (HPO:0000358) Posteriorly rotated ears 19318041 IBIS 163 / 7739
108
 (HPO:0000303) Mandibular prognathia 19318041 IBIS 179 / 7739
109
 (HPO:0001955) Unexplained fevers 19318041 IBIS 7 / 7739
110
 (HPO:0007957) Corneal opacity 19318041; 19092368 IBIS 84 / 7739
111
 (HPO:0002829) Arthralgia 19318041; 25977923; 22431073 IBIS 79 / 7739
112
 (HPO:0010829) Impaired temperature sensation 19318041 IBIS 5 / 7739
113
 (MedDRA:10007697) Carpal tunnel syndrome 19318041 IBIS 16 / 7739
114
 (HPO:0000408) Progressive sensorineural hearing impairment 19318041 IBIS 28 / 7739
115
 (HPO:0012214) Increased glomerular filtration rate 19318041 IBIS 1 / 7739
116
 (HPO:0003158) Hyposthenuria 19318041 IBIS 6 / 7739
117
 (HPO:0000103) Polyuria 19318041; 17657109 IBIS 60 / 7739
118
 (HPO:0001639) Hypertrophic cardiomyopathy 19318041 IBIS 137 / 7739
119
 (HPO:0004756) Ventricular tachycardia 19318041 IBIS 55 / 7739
120
 (HPO:0005165) Shortened PR interval 19318041; 19092368 IBIS 9 / 7739
121
 (HPO:0005110) Atrial fibrillation 19318041 IBIS 71 / 7739
122
 (HPO:0005145) Coronary artery stenosis 19318041 IBIS 5 / 7739
123
 (HPO:0012664) Reduced ejection fraction 19318041 IBIS 32 / 7739
124
 (MedDRA:10007595) Cardiac output decreased 19318041 IBIS 3 / 7739
125
 (HPO:0000821) Hypothyroidism 19318041 IBIS 141 / 7739
126
 (HPO:0012207) Reduced sperm motility 19318041 IBIS 5 / 7739
127
 (HPO:0000798) Oligospermia 19318041 IBIS 13 / 7739
128
 (HPO:0003565) Elevated erythrocyte sedimentation rate 19318041 IBIS 31 / 7739
129
 (HPO:0010990) Abnormality of the common coagulation pathway 19318041 IBIS 1 / 7739
130
 (HPO:0010741) Edema of the lower limbs 19318041; 26179544; 16799480 IBIS 34 / 7739
131
 (HPO:0001970) Tubulointerstitial nephritis 26179544 IBIS 27 / 7739
132
 (HPO:0012622) Chronic kidney disease 25977923 IBIS 32 / 7739
133
 (MedDRA:10062198) Microangiopathy 25977923 IBIS 4 / 7739
134
 (MedDRA:10054805) Macroangiopathy 25977923 IBIS 1 / 7739
135
 (HPO:0001959) Polydipsia 17657109 IBIS 43 / 7739
136
 (HPO:0001947) Renal tubular acidosis 17657109 IBIS 21 / 7739
137
 (HPO:0003355) Aminoaciduria 17657109 IBIS 65 / 7739
138
 (HPO:0003076) Glycosuria 17657109 IBIS 32 / 7739
139
 (HPO:0002046) Heat intolerance 17657109 IBIS 13 / 7739
140
 (HPO:0000217) Xerostomia 17657109 IBIS 35 / 7739
141
 (HPO:0000633) Decreased lacrimation 17657109 IBIS 6 / 7739
142
 (HPO:0000751) Personality changes 17657109 IBIS 33 / 7739
143
 (MedDRA:10042458) Suicidal ideation 17657109 IBIS 1 / 7739
144
 (HPO:0000503) Tortuosity of conjunctival vessels 17657109 IBIS 3 / 7739
145
 (HPO:0001678) Atrioventricular block 17657109; 19092368 IBIS 59 / 7739
146
 (HPO:0001649) Tachycardia 17657109 IBIS 53 / 7739
147
 (HPO:0012249) Abnormal ST segment 17657109 IBIS 3 / 7739
148
 (MedDRA:10050380) Electrocardiogram T wave abnormal 17657109 IBIS 5 / 7739
149
 (HPO:0002617) Aneurysm 17657109 IBIS 34 / 7739
150
 (HPO:0002301) Hemiplegia 17657109 IBIS 42 / 7739
151
 (HPO:0004948) Vascular tortuosity 17657109 IBIS 5 / 7739
152
 (HPO:0005315) Peripheral artery occlusive disease 17657109 IBIS 7 / 7739
153
 (HPO:0011024) Abnormality of the gastrointestinal tract 17657109 IBIS 5 / 7739
154
 (HPO:0003270) Abdominal distention 17657109 IBIS 46 / 7739
155
 (HPO:0000716) Depression 17657109; 23448452 IBIS 99 / 7739
156
 (HPO:0000092) Tubular atrophy 17657109; 16799480 IBIS 28 / 7739
157
 (HPO:0005576) Tubulointerstitial fibrosis 17657109; 16799480 IBIS 32 / 7739
158
 (MedDRA:10065297) Urinary lipids present 17657109 IBIS 1 / 7739
159
 (HPO:0004727) Impaired renal concentrating ability 17657109 IBIS 6 / 7739
160
 (HPO:0009806) Nephrogenic diabetes insipidus 17657109 IBIS 8 / 7739
161
 (HPO:0008341) Distal renal tubular acidosis 17657109 IBIS 6 / 7739
162
 (HPO:0003138) Increased blood urea nitrogen 17657109; 19092368 IBIS 14 / 7739
163
 (HPO:0001962) Palpitations 19092368; 22431073 IBIS 62 / 7739
164
 (HPO:0003388) Easy fatigability 19092368 IBIS 34 / 7739
165
 (OMIM) Decreased exercise capacity 19092368 IBIS 2 / 7739
166
 (HPO:0007185) Loss of consciousness 19092368 IBIS 9 / 7739
167
 (HPO:0012250) ST segment depression 19092368 IBIS 7 / 7739
168
 (HPO:0005115) Supraventricular arrhythmia 19092368 IBIS 13 / 7739
169
 (HPO:0012232) Shortened QT interval 19092368 IBIS 7 / 7739
170
 (HPO:0001634) Mitral valve prolapse 19092368 IBIS 69 / 7739
171
 (HPO:0001670) Asymmetric septal hypertrophy 19092368 IBIS 19 / 7739
172
 (HPO:0002616) Aortic root dilatation 19092368 IBIS 27 / 7739
173
 (HPO:0012211) Abnormal renal physiology 16799480 IBIS 23 / 7739
174
 (HPO:0004343) Abnormality of glycosphingolipid metabolism 16799480 IBIS 3 / 7739
175
 (HPO:0003259) Elevated serum creatinine 16799480 IBIS 31 / 7739
176
 (HPO:0000988) Skin rash 16799480 IBIS 98 / 7739
177
 (HPO:0012432) Chronic fatigue 22431073 IBIS 5 / 7739
178
 (HPO:0030018) Decreased female libido 22431073 IBIS 1 / 7739
179
 (HPO:0045059) Hyperkeratotic papule 16403380 IBIS 4 / 7739