|
1
|
(HPO:0001260)
|
Dysarthria |
|
|
|
|
329 / 7739
|
|
2
|
(HPO:0001265)
|
Hyporeflexia |
|
|
|
|
208 / 7739
|
|
3
|
(HPO:0001284)
|
Areflexia |
|
|
|
|
198 / 7739
|
|
4
|
(HPO:0001348)
|
Brisk reflexes |
rare [HPO:skoehler]
|
|
|
|
15 / 7739
|
|
5
|
(HPO:0002015)
|
Dysphagia |
|
|
|
|
301 / 7739
|
|
6
|
(HPO:0002145)
|
Frontotemporal dementia |
rare [HPO:skoehler]
|
|
|
|
14 / 7739
|
|
7
|
(HPO:0002380)
|
Fasciculations |
|
|
|
|
42 / 7739
|
|
8
|
(HPO:0002483)
|
Bulbar signs |
|
|
|
|
9 / 7739
|
|
9
|
(HPO:0002747)
|
Respiratory insufficiency due to muscle weakness |
|
|
|
|
48 / 7739
|
|
10
|
(HPO:0003202)
|
Skeletal muscle atrophy |
|
|
|
|
281 / 7739
|
|
11
|
(HPO:0003487)
|
Babinski sign |
rare [HPO:skoehler]
|
|
|
|
179 / 7739
|
|
12
|
(HPO:0001324)
|
Muscle weakness |
|
|
|
|
859 / 7739
|
|
13
|
(OMIM)
|
Lower motor neuron dysfunction involving Upper and lower limbs |
|
|
|
|
1 / 7739
|
|
14
|
(OMIM)
|
Lack of upper motor neuron signs |
|
|
|
|
1 / 7739
|
|
15
|
(OMIM)
|
Flexor plantar responses |
|
|
|
|
2 / 7739
|
|
16
|
(OMIM)
|
Loss of motor neurons in the spinal cord |
|
|
|
|
2 / 7739
|
|
17
|
(OMIM)
|
Intraneuronal inclusions |
|
|
|
|
1 / 7739
|
|
18
|
(OMIM)
|
Lack of skein-like inclusions |
|
|
|
|
1 / 7739
|
|
19
|
(OMIM)
|
Lack of Bunina bodies |
|
|
|
|
1 / 7739
|
|
20
|
(HPO:0000006)
|
Autosomal dominant inheritance |
|
|
|
|
2518 / 7739
|
|
21
|
(HPO:0003581)
|
Adult onset |
|
|
|
|
117 / 7739
|
|
22
|
(HPO:0003678)
|
Rapidly progressive |
|
|
|
|
33 / 7739
|
|
23
|
(HPO:0007354)
|
Amyotrophic lateral sclerosis |
|
|
|
|
25 / 7739
|