Elevated alkaline phosphatase

Symptom Information:

Symptom ID: HPO:0003155
Synonyms:
Greatly elevated alkaline phosphatase [HPO:0003155]
High serum alkaline phosphatase [HPO:0003155]
Hyperphosphatasia [HPO:0003155]
Increased alkaline phosphatase [HPO:0003155]
Increased serum alkaline phosphatase [HPO:0003155]
Elevated alkaline phosphatase [OMIM:Elevated alkaline phosphatase]
High serum alkaline phosphatase [OMIM:High serum alkaline phosphatase]
Hyperphosphatasia [OMIM:Hyperphosphatasia]
Increased alkaline phosphatase [OMIM:Increased alkaline phosphatase]
Increased serum alkaline phosphatase [OMIM:Increased serum alkaline phosphatase]
Elevated alkaline phosphatase (if more than one affected site) [OMIM:Elevated alkaline phosphatase (if more than one affected site)]
Elevated alkaline phosphatase (in one patient) [OMIM:Elevated alkaline phosphatase (in one patient)]
Elevated alkaline phosphatase (varies from 1.3-20 times age-adjusted upper limit of normal) [OMIM:Elevated alkaline phosphatase (varies from 1.3-20 times age-adjusted upper limit of normal)]
Increased serum alkaline phosphatase (1 patient) [OMIM:Increased serum alkaline phosphatase (1 patient)]
Quality:
Cross references:
OMIM: "Elevated alkaline phosphatase" [OMIM:Elevated alkaline phosphatase]
OMIM: "High serum alkaline phosphatase" [OMIM:High serum alkaline phosphatase]
OMIM: "Hyperphosphatasia" [OMIM:Hyperphosphatasia]
OMIM: "Increased alkaline phosphatase" [OMIM:Increased alkaline phosphatase]
OMIM: "Increased serum alkaline phosphatase" [OMIM:Increased serum alkaline phosphatase]
OMIM: "Elevated alkaline phosphatase (if more than one affected site)" [OMIM:Elevated alkaline phosphatase (if more than one affected site)]
OMIM: "Elevated alkaline phosphatase (in one patient)" [OMIM:Elevated alkaline phosphatase (in one patient)]
OMIM: "Elevated alkaline phosphatase (varies from 1.3-20 times age-adjusted upper limit of normal)" [OMIM:Elevated alkaline phosphatase (varies from 1.3-20 times age-adjusted upper limit of normal)]
OMIM: "Increased serum alkaline phosphatase (1 patient)" [OMIM:Increased serum alkaline phosphatase (1 patient)]
Is a (Direct Parents):
HPO         Abnormality of alkaline phosphatase activity
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of metabolism/homeostasis(HPO:0001939)
          Abnormal enzyme/coenzyme activity(HPO:0012379)
             Abnormality of alkaline phosphatase activity(HPO:0004379)
                Elevated alkaline phosphatase(HPO:0003155)
MedDRA:
Database Frequency: 52 / 7739
Resource:

All diseases associated with this symptom:

ALKALINE PHOSPHATASE, PLASMA LEVEL OF, QUANTITATIVE TRAIT LOCUS 1 (OMIM:171720)
AMYOTROPHIC LATERAL SCLEROSIS 20 (OMIM:615426)
ARTERITIS, FAMILIAL GRANULOMATOUS, WITH JUVENILE POLYARTHRITIS (OMIM:108050)
Alström syndrome (Orphanet:64)
Autosomal dominant hypophosphatemic rickets (Orphanet:89937)
Autosomal recessive malignant osteopetrosis (Orphanet:667)
Benign recurrent intrahepatic cholestasis type 2 (Orphanet:99961)
COG4-CDG (Orphanet:263501)
CRANIODIAPHYSEAL DYSPLASIA, AUTOSOMAL DOMINANT (OMIM:122860)
CRANIOMETADIAPHYSEAL DYSPLASIA (OMIM:269300)
Calvarial doughnut lesions - bone fragility (Orphanet:85192)
Cholestasis - lymphedema (Orphanet:1414)
Congenital bile acid synthesis defect type 2 (Orphanet:79303)
Congenital bile acid synthesis defect type 3 (Orphanet:79302)
Craniodiaphyseal dysplasia (Orphanet:1513)
Craniometadiaphyseal dysplasia, wormian bone type (Orphanet:85184)
Familial expansile osteolysis (Orphanet:85195)
Glycogen storage disease due to GLUT2 deficiency (Orphanet:2088)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 1 (OMIM:239300)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 2 (OMIM:614749)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 3 (OMIM:614207)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 4 (OMIM:615716)
HYPERPHOSPHATASIA WITH MENTAL RETARDATION SYNDROME 5 (OMIM:616025)
Hereditary hypophosphatemic rickets with hypercalciuria (Orphanet:157215)
Hyperostosis corticalis generalisata (Orphanet:3416)
Hyperphosphatasia-intellectual deficiency syndrome (Orphanet:247262)
Hypocalcemic vitamin D-dependent rickets (Orphanet:289157)
Hypocalcemic vitamin D-resistant rickets (Orphanet:93160)
Hypophosphatemic rickets, autosomal recessive, 2 (OMIM:613312)
Isolated polycystic liver disease (Orphanet:2924)
Lathosterolosis (Orphanet:46059)
Lethal osteosclerotic bone dysplasia (Orphanet:1832)
Low phospholipid associated cholelithiasis (Orphanet:69663)
Metaphyseal chondrodysplasia, Jansen type (Orphanet:33067)
Morgagni-Stewart-Morel syndrome (Orphanet:77296)
Mucopolysaccharidosis type 2 (Orphanet:580)
Multiple congenital anomalies-hypotonia-seizures syndrome type 2 (Orphanet:300496)
OSTEOGENESIS IMPERFECTA, TYPE XI (OMIM:610968)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 1 (OMIM:259700)
OSTEOSCLEROTIC METAPHYSEAL DYSPLASIA (OMIM:615198)
PAGET DISEASE OF BONE (OMIM:602080)
PAGET DISEASE OF BONE 1 (OMIM:167250)
PAGET DISEASE OF BONE 4 (OMIM:606263)
Pearson syndrome (Orphanet:699)
Primary Fanconi syndrome (Orphanet:3337)
Progressive familial intrahepatic cholestasis type 2 (Orphanet:79304)
Reynolds syndrome (Orphanet:779)
VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A (OMIM:264700)
VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1B (OMIM:600081)
VITAMIN D-DEPENDENT RICKETS, TYPE 2A (OMIM:277440)
VITAMIN D-DEPENDENT RICKETS, TYPE 2B, WITH NORMAL VITAMIN D RECEPTOR (OMIM:600785)
X-linked hypophosphatemia (Orphanet:89936)