Exaggerated startle response

Symptom Information:

Symptom ID: HPO:0002267
Synonyms:
Exaggerated acoustic startle response [HPO:0002267]
Hyperekplexia [HPO:0002267]
Increased startle response [HPO:0002267]
Hyperreflexia [Orphanet:43360]
Hyperreflexia (finding) [Orphanet:43360]
Exaggerated startle response [Orphanet:43080]
Exaggerated acoustic startle response [OMIM:Exaggerated acoustic startle response]
Exaggerated startle response [OMIM:Exaggerated startle response]
Hyperekplexia [OMIM:Hyperekplexia]
Increased startle response [OMIM:Increased startle response]
Hypereflexia [Orphanet:43360]
Incessant startle response to noise [Orphanet:43080]
Hyperreflexia [MedDRA:10020745]
Achilles tendon reflex exaggerated [MedDRA:10020745]
Exaggerated reflexes [MedDRA:10020745]
Increased reflexes [MedDRA:10020745]
Patellar tendon reflex increased [MedDRA:10020745]
Reflex positive pathological [MedDRA:10020745]
Reflexes increased [MedDRA:10020745]
Reflexes tendon increased [MedDRA:10020745]
Tendon reflex exaggerated [MedDRA:10020745]
Exaggerated startle response [MedDRA:10066482]
Hyperekplexia (rare) [OMIM:Hyperekplexia (rare)]
Hyperreflexia (1 patient) [OMIM:Hyperreflexia (1 patient)]
Hyperreflexia (33%) [OMIM:Hyperreflexia (33%)]
Hyperreflexia (70%) [OMIM:Hyperreflexia (70%)]
Hyperreflexia (early) [OMIM:Hyperreflexia (early)]
Hyperreflexia (in 2 of 7 patients) [OMIM:Hyperreflexia (in 2 of 7 patients)]
Hyperreflexia (in some patients) [OMIM:Hyperreflexia (in some patients)]
Hyperreflexia (in some) [OMIM:Hyperreflexia (in some)]
Hyperreflexia (later) [OMIM:Hyperreflexia (later)]
Hyperreflexia (less common) [OMIM:Hyperreflexia (less common)]
Hyperreflexia (particularly in lower extremities, more prevalent in adolescents and adults) [OMIM:Hyperreflexia (particularly in lower extremities, more prevalent in adolescents and adults)]
Hyperreflexia (some patients) [OMIM:Hyperreflexia (some patients)]
Hyperreflexia (type I) [OMIM:Hyperreflexia (type I)]
Hyperreflexia (uncommon) [OMIM:Hyperreflexia (uncommon)]
Increased tendon reflex [OMIM:Increased tendon reflex]
Quality:
Cross references:
HPO:0007034 "Generalized hyperreflexia" [Orphanet:43360]
HPO:0001347 "Hyperreflexia" [Orphanet:43360]
Orphanet:43360 "Hypereflexia" [Orphanet:43360]
Orphanet:43080 "Incessant startle response to noise" [Orphanet:43080]
OMIM: "Exaggerated acoustic startle response" [OMIM:Exaggerated acoustic startle response]
OMIM: "Exaggerated startle response" [OMIM:Exaggerated startle response]
OMIM: "Hyperekplexia" [OMIM:Hyperekplexia]
OMIM: "Increased startle response" [OMIM:Increased startle response]
OMIM: "Hyperekplexia (rare)" [OMIM:Hyperekplexia (rare)]
OMIM: "Hyperreflexia (1 patient)" [OMIM:Hyperreflexia (1 patient)]
OMIM: "Hyperreflexia (33%)" [OMIM:Hyperreflexia (33%)]
OMIM: "Hyperreflexia (70%)" [OMIM:Hyperreflexia (70%)]
OMIM: "Hyperreflexia (early)" [OMIM:Hyperreflexia (early)]
OMIM: "Hyperreflexia (in 2 of 7 patients)" [OMIM:Hyperreflexia (in 2 of 7 patients)]
OMIM: "Hyperreflexia (in some patients)" [OMIM:Hyperreflexia (in some patients)]
OMIM: "Hyperreflexia (in some)" [OMIM:Hyperreflexia (in some)]
OMIM: "Hyperreflexia (later)" [OMIM:Hyperreflexia (later)]
OMIM: "Hyperreflexia (less common)" [OMIM:Hyperreflexia (less common)]
OMIM: "Hyperreflexia (particularly in lower extremities, more prevalent in adolescents and adults)" [OMIM:Hyperreflexia (particularly in lower extremities, more prevalent in adolescents and adults)]
OMIM: "Hyperreflexia (some patients)" [OMIM:Hyperreflexia (some patients)]
OMIM: "Hyperreflexia (type I)" [OMIM:Hyperreflexia (type I)]
OMIM: "Hyperreflexia (uncommon)" [OMIM:Hyperreflexia (uncommon)]
OMIM: "Increased tendon reflex" [OMIM:Increased tendon reflex]
UMLS:C0151889 "Hyperreflexia" [Orphanet:43360]
UMLS:C1740801 "Exaggerated startle response" [Orphanet:43080]
Is a (Direct Parents):
Orphanet [DEL]Motor deficit/trouble
MedDRA Abnormal reflexes
HPO         Abnormality of extrapyramidal motor function
Orphanet Functional anomalies of the nervous system
MedDRA Psychiatric symptoms NEC
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the nervous system(HPO:0000707)
          Abnormality of nervous system physiology(HPO:0012638)
             Abnormality of central motor function(HPO:0011442)
                Abnormality of extrapyramidal motor function(HPO:0002071)
                   Exaggerated startle response(HPO:0002267)
MedDRA:
Nervous system disorders(MedDRA:10029205)
    Neurological disorders NEC(MedDRA:10029305)
       Abnormal reflexes(MedDRA:10000171)
          Exaggerated startle response(HPO:0002267)
Database Frequency: 42 / 7739
Resource:

All diseases associated with this symptom:

3-methylglutaconic aciduria type 1 (Orphanet:67046)
3-methylglutaconic aciduria type 3 (Orphanet:67047)
6-pyruvoyl-tetrahydropterin synthase deficiency (Orphanet:13)
ASPARAGINE SYNTHETASE DEFICIENCY (OMIM:615574)
Autosomal dominant Charcot-Marie-Tooth disease type 2A2 (Orphanet:99947)
Autosomal dominant childhood-onset proximal spinal muscular atrophy with contractures (Orphanet:363454)
Autosomal dominant dopa-responsive dystonia (Orphanet:98808)
Autosomal recessive spastic paraplegia type 43 (Orphanet:320370)
CARASIL (Orphanet:199354)
Classical phenylketonuria (Orphanet:79254)
Congenital myopathy with excess of thin filaments (Orphanet:98904)
GM2-gangliosidosis, AB variant (Orphanet:309246)
Gaucher disease type 2 (Orphanet:77260)
HYPEREKPLEXIA 2 (OMIM:614619)
HYPEREKPLEXIA 3 (OMIM:614618)
HYPEREKPLEXIA, HEREDITARY 1 (OMIM:149400)
Hereditary hyperekplexia (Orphanet:3197)
Huntington disease (Orphanet:399)
Hyperekplexia - epilepsy (Orphanet:163985)
Hyperornithinemia-hyperammonemia-homocitrullinuria (Orphanet:415)
Lethal ataxia with deafness and optic atrophy (Orphanet:1187)
METACHROMATIC LEUKODYSTROPHY (OMIM:250100)
MITOCHONDRIAL COMPLEX III DEFICIENCY, NUCLEAR TYPE 2 (OMIM:615157)
MUSCULAR DYSTROPHY-DYSTROGLYCANOPATHY (CONGENITAL WITH BRAIN AND EYEANOMALIES), TYPE A, 4 (OMIM:253800)
Maternal hyperphenylalaninemia (Orphanet:2209)
Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus (Orphanet:83473)
Multiple congenital anomalies - hypotonia - seizures syndrome (Orphanet:280633)
NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A (OMIM:256600)
NEUROPATHY, HEREDITARY SENSORY, TYPE ID (OMIM:613708)
Neurodegeneration with brain iron accumulation due to C19orf12 mutation (Orphanet:289560)
PARKINSON DISEASE 6, AUTOSOMAL RECESSIVE EARLY-ONSET (OMIM:605909)
Pontine tegmental cap dysplasia (Orphanet:269229)
Sialidosis type 1 (Orphanet:812)
Spastic paraplegia-optic atrophy-neuropathy syndrome (Orphanet:320406)
Spectrin-associated autosomal recessive cerebellar ataxia (Orphanet:352403)
Spinocerebellar ataxia type 1 (Orphanet:98755)
Spinocerebellar ataxia type 19/22 (Orphanet:98772)
Sporadic Leigh syndrome (Orphanet:255199)
Stiff person syndrome (Orphanet:3198)
Tay-Sachs disease (Orphanet:845)
Williams syndrome (Orphanet:904)
X-linked parkinsonism-spasticity syndrome (Orphanet:363654)