Hepatosplenomegaly

Symptom Information:

Symptom ID: HPO:0001433
Synonyms:
Hepatosplenomegaly [OMIM:Hepatosplenomegaly]
Hepatosplenomegaly (rare) [OMIM:Hepatosplenomegaly (rare)]
Hepatosplenomegaly [MedDRA:10019847]
Quality:
Cross references:
OMIM: "Hepatosplenomegaly" [OMIM:Hepatosplenomegaly]
OMIM: "Hepatosplenomegaly (rare)" [OMIM:Hepatosplenomegaly (rare)]
UMLS:C0019214 "Hepatosplenomegaly" [HPO:0001433]
Is a (Direct Parents):
HPO         Abnormality of the spleen
MedDRA Liver and spleen enlargement
HPO         Visceromegaly
HPO         Abnormality of the liver
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the abdomen(HPO:0001438)
          Abnormality of the abdominal organs(HPO:0002012)
             Abnormality of the liver(HPO:0001392)
                Hepatosplenomegaly(HPO:0001433)
             Abnormality of the spleen(HPO:0001743)
                Hepatosplenomegaly(HPO:0001433)
             Visceromegaly(HPO:0003271)
                Hepatosplenomegaly(HPO:0001433)
       Abnormality of the immune system(HPO:0002715)
          Abnormality of the lymphatic system(HPO:0100763)
             Abnormality of the spleen(HPO:0001743)
                Hepatosplenomegaly(HPO:0001433)
MedDRA:
Blood and lymphatic system disorders(MedDRA:10005329)
    Spleen, lymphatic and reticuloendothelial system disorders(MedDRA:10041641)
       Liver and spleen enlargement(MedDRA:10057180)
          Hepatosplenomegaly(HPO:0001433)
Database Frequency: 78 / 7739
Resource:

All diseases associated with this symptom:

AICARDI-GOUTIERES SYNDROME 1 (OMIM:225750)
AICARDI-GOUTIERES SYNDROME 3 (OMIM:610329)
AICARDI-GOUTIERES SYNDROME 4 (OMIM:610333)
ANEMIA, SIDEROBLASTIC, PYRIDOXINE-RESPONSIVE, AUTOSOMAL RECESSIVE (OMIM:206000)
AREDYLD syndrome (Orphanet:1133)
ATP-BINDING CASSETTE, SUBFAMILY D, MEMBER 3 (OMIM:170995)
Alström syndrome (Orphanet:64)
Atypical Gaucher disease due to saposin C deficiency (Orphanet:309252)
Bardet-Biedl syndrome 1 (OMIM:209900 )
Cholesteryl ester storage disease (Orphanet:75234)
Early-onset familial noncirrhotic portal hypertension (ORPHA:494348)
FGFR2-related bent bone dysplasia (Orphanet:313855)
Familial lipoprotein lipase deficiency (Orphanet:309015)
Farber lipogranulomatosis (Orphanet:333)
Fetal Gaucher disease (Orphanet:85212)
GOLGI REASSEMBLY STACKING PROTEIN 1 (OMIM:606867)
Galactosialidosis (Orphanet:351)
Gaucher disease - ophthalmoplegia - cardiovascular calcification (Orphanet:2072)
Gaucher disease type 1 (Orphanet:77259)
Gaucher disease type 2 (Orphanet:77260)
Gaucher disease type 3 (Orphanet:77261)
Generalized congenital lipodystrophy with myopathy (Orphanet:228429)
Glycogen storage disease due to glycogen branching enzyme deficiency (Orphanet:367)
Glycogen storage disease due to glycogen branching enzyme deficiency, adult neuromuscular form (Orphanet:308712)
Glycogen storage disease due to glycogen branching enzyme deficiency, childhood combined hepatic and myopathic form (Orphanet:308684)
Glycogen storage disease due to glycogen branching enzyme deficiency, childhood neuromuscular form (Orphanet:308698)
Glycogen storage disease due to glycogen branching enzyme deficiency, congenital neuromuscular form (Orphanet:308670)
Glycogen storage disease due to glycogen branching enzyme deficiency, fatal perinatal neuromuscular form (Orphanet:308655)
Glycogen storage disease due to glycogen branching enzyme deficiency, non progressive hepatic form (Orphanet:308638)
Glycogen storage disease due to glycogen branching enzyme deficiency, progressive hepatic form (Orphanet:308621)
Glycogen storage disease due to glycogen debranching enzyme deficiency (Orphanet:366)
Greenberg dysplasia (Orphanet:1426)
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 3 (OMIM:608898)
HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS, FAMILIAL, 5 (OMIM:613101)
Hemochromatosis type 3 (Orphanet:225123)
Hemochromatosis, type 2B (OMIM:613313)
Hereditary North American Indian childhood cirrhosis (Orphanet:168583)
Hereditary neutrophilia (Orphanet:279943)
Hurler syndrome (Orphanet:93473)
Hurler-Scheie syndrome (Orphanet:93476)
Ichthyosis - hepatosplenomegaly - cerebellar degeneration (Orphanet:2274)
Immunodeficiency due to CD25 deficiency (Orphanet:169100)
LIPODYSTROPHY, CONGENITAL GENERALIZED, TYPE 3 (OMIM:612526)
Lathosterolosis (Orphanet:46059)
Lethal hemolytic anemia - genital anomalies (Orphanet:1046)
Letterer-Siwe disease (Orphanet:99870)
Lysosomal acid lipase deficiency (Orphanet:275761)
McLeod neuroacanthocytosis syndrome (Orphanet:59306)
Mucopolysaccharidosis type 1 (Orphanet:579)
Mucopolysaccharidosis type 2 (Orphanet:580)
Mucopolysaccharidosis type 2, attenuated form (Orphanet:217093)
Mucopolysaccharidosis type 2, severe form (Orphanet:217085)
Mulibrey nanism (Orphanet:2576)
Neonatal hemochromatosis (Orphanet:446)
Neonatal intrahepatic cholestasis due to citrin deficiency (Orphanet:247598)
Nephronophthisis 19 (OMIM:616217)
Niemann-Pick disease type A (Orphanet:77292)
Niemann-Pick disease type B (Orphanet:77293)
Noonan syndrome (Orphanet:648)
Noonan syndrome-like disorder with juvenile myelomonocytic leukemia (Orphanet:363972)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4 (OMIM:611490)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 2 (OMIM:259710)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 3 (OMIM:259730)
Osteopetrosis with renal tubular acidosis (Orphanet:2785)
PEROXISOME BIOGENESIS DISORDER 5A (ZELLWEGER) (OMIM:614866)
Pediatric systemic lupus erythematosus (Orphanet:93552)
RETICULOENDOTHELIOSIS, X-LINKED (OMIM:312500)
Sandhoff disease (Orphanet:796)
Sandhoff disease, adult form (Orphanet:309169)
Sandhoff disease, infantile form (Orphanet:309155)
Sandhoff disease, juvenile form (Orphanet:309162)
Scheie syndrome (Orphanet:93474)
THANATOPHORIC DYSPLASIA, GLASGOW VARIANT (OMIM:273680)
Thrombocytopenia - absent radius (Orphanet:3320)
Thymic aplasia (Orphanet:83471)
Transaldolase deficiency (Orphanet:101028)
Wolman disease (Orphanet:75233)
Zellweger-like syndrome without peroxisomal anomalies (Orphanet:50812)