1
|
(HPO:0000822)
|
Hypertension |
|
|
|
|
224 / 7739
|
2
|
(HPO:0001250)
|
Seizures |
|
|
|
|
1245 / 7739
|
3
|
(HPO:0001259)
|
Coma |
|
|
|
|
65 / 7739
|
4
|
(HPO:0001269)
|
Hemiparesis |
|
|
|
|
51 / 7739
|
5
|
(HPO:0001873)
|
Thrombocytopenia |
|
|
|
|
224 / 7739
|
6
|
(HPO:0001919)
|
Acute kidney injury |
|
|
|
|
21 / 7739
|
7
|
(HPO:0001923)
|
Reticulocytosis |
|
|
|
|
28 / 7739
|
8
|
(HPO:0001937)
|
Microangiopathic hemolytic anemia |
|
|
|
|
12 / 7739
|
9
|
(HPO:0001981)
|
Schistocytosis |
|
|
|
|
7 / 7739
|
10
|
(HPO:0002357)
|
Dysphasia |
|
|
|
|
33 / 7739
|
11
|
(HPO:0003077)
|
Hyperlipidemia |
|
|
|
|
37 / 7739
|
12
|
(HPO:0003138)
|
Increased blood urea nitrogen |
|
|
|
|
14 / 7739
|
13
|
(HPO:0003259)
|
Elevated serum creatinine |
|
|
|
|
31 / 7739
|
14
|
(HPO:0005416)
|
Decreased serum complement factor B |
|
|
|
|
6 / 7739
|
15
|
(HPO:0005421)
|
Decreased serum complement C3 |
|
|
|
|
9 / 7739
|
16
|
(HPO:0100519)
|
Anuria |
|
|
|
|
20 / 7739
|
17
|
(HPO:0100543)
|
Cognitive impairment |
|
|
|
|
230 / 7739
|
18
|
(OMIM)
|
Prodrome of gastroenteric diarrhea, usually caused by E. coli 0157-H7 or shigella in young children (typical HUS) |
|
|
|
|
3 / 7739
|
19
|
(OMIM)
|
Global and focal neurologic abnormalities (less than 30%) |
|
|
|
|
3 / 7739
|
20
|
(OMIM)
|
Visual defects |
|
|
|
|
4 / 7739
|
21
|
(MedDRA:10043645)
|
Thrombotic microangiopathy |
|
|
|
|
11 / 7739
|
22
|
(OMIM)
|
'Burr cells' |
|
|
|
|
4 / 7739
|
23
|
(OMIM)
|
Complement component consumption |
|
|
|
|
3 / 7739
|
24
|
(OMIM)
|
Defective complement regulation |
|
|
|
|
8 / 7739
|
25
|
(OMIM)
|
Activation of the complement system |
|
|
|
|
3 / 7739
|
26
|
(OMIM)
|
Some patients may have autoantibodies to factor H, resulting in functional factor H deficiency |
|
|
|
|
3 / 7739
|
27
|
(HPO:0001903)
|
Anemia |
|
|
|
|
289 / 7739
|
28
|
(OMIM)
|
Decreased serum factor H (atypical HUS) |
|
|
|
|
3 / 7739
|
29
|
(OMIM)
|
Decreased serum factor I (atypical HUS) |
|
|
|
|
3 / 7739
|
30
|
(OMIM)
|
Normal activity of von Willebrand factor-cleaving protease |
|
|
|
|
3 / 7739
|