Symptom Information: Sort according to HPO 

1
 (HPO:0001387) Joint stiffness Very frequent [Orphanet] 322 / 7739
2
 (HPO:0001000) Abnormality of skin pigmentation Occasional [Orphanet] 105 / 7739
3
 (HPO:0009882) Short distal phalanx of finger Very frequent [Orphanet] 125 / 7739
4
 (HPO:0001252) Muscular hypotonia Occasional [Orphanet] 990 / 7739
5
 (HPO:0001596) Alopecia Very frequent [Orphanet] 162 / 7739
6
 (HPO:0000164) Abnormality of the teeth Occasional [Orphanet] 291 / 7739
7
 (HPO:0005059) Arthralgia/arthritis Occasional [Orphanet] 141 / 7739
8
 (HPO:0100783) Breast aplasia Occasional [Orphanet] 19 / 7739
9
 (HPO:0000678) Dental crowding 65 / 7739
10
 (HPO:0002763) Abnormal cartilage morphology Occasional [Orphanet] 15 / 7739
11
 (HPO:0000520) Proptosis Frequent [Orphanet] 192 / 7739
12
 (HPO:0100679) Lack of skin elasticity Occasional [Orphanet] 29 / 7739
13
 (HPO:0000218) High palate 356 / 7739
14
 (HPO:0002705) High, narrow palate Occasional [Orphanet] 308 / 7739
15
 (HPO:0002797) Osteolysis Very frequent [Orphanet] 68 / 7739
16
 (HPO:0000239) Large fontanelles Very frequent [Orphanet] 135 / 7739
17
 (HPO:0007495) Prematurely aged appearance Very frequent [Orphanet] 44 / 7739
18
 (HPO:0003077) Hyperlipidemia 37 / 7739
19
 (HPO:0000518) Cataract Occasional [Orphanet] 454 / 7739
20
 (HPO:0000365) Hearing impairment Occasional [Orphanet] 539 / 7739
21
 (HPO:0000831) Insulin-resistant diabetes mellitus 22 / 7739
22
 (HPO:0000855) Insulin resistance Frequent [Orphanet] 32 / 7739
23
 (HPO:0004322) Short stature Very frequent [Orphanet] 1232 / 7739
24
 (HPO:0006660) Aplastic clavicles Very frequent [Orphanet] 70 / 7739
25
 (HPO:0004334) Dermal atrophy 34 / 7739
26
 (HPO:0002645) Wormian bones Very frequent [Orphanet] 65 / 7739
27
 (HPO:0000534) Abnormality of the eyebrow Frequent [Orphanet] 39 / 7739
28
 (HPO:0000293) Full cheeks 85 / 7739
29
 (HPO:0000320) Bird-like facies 4 / 7739
30
 (HPO:0000347) Micrognathia 426 / 7739
31
 (HPO:0000418) Narrow nasal ridge 15 / 7739
32
 (HPO:0000685) Hypoplasia of teeth 12 / 7739
33
 (HPO:0000833) Glucose intolerance 20 / 7739
34
 (HPO:0000842) Hyperinsulinemia 39 / 7739
35
 (HPO:0000894) Short clavicles 30 / 7739
36
 (HPO:0000905) Progressive clavicular acroosteolysis 4 / 7739
37
 (HPO:0001070) Mottled pigmentation 8 / 7739
38
 (HPO:0001371) Flexion contracture 220 / 7739
39
 (HPO:0003074) Hyperglycemia 37 / 7739
40
 (HPO:0003119) Abnormality of lipid metabolism Frequent [Orphanet] 60 / 7739
41
 (HPO:0003635) Loss of subcutaneous adipose tissue in limbs 6 / 7739
42
 (HPO:0006480) Premature loss of teeth 23 / 7739
43
 (HPO:0008065) Aplasia/Hypoplasia of the skin Very frequent [Orphanet] 81 / 7739
44
 (HPO:0008897) Postnatal growth retardation 113 / 7739
45
 (HPO:0009839) Osteolytic defects of the distal phalanges of the hand 6 / 7739
46
 (OMIM) Normal or increased facial adipose tissue 3 / 7739
47
 (OMIM) Pointed nose 2 / 7739
48
 (OMIM) Beak nose 1 / 7739
49
 (OMIM) Absence of tongue papillae 1 / 7739
50
 (OMIM) Normal or increased adipose tissue around the neck 3 / 7739
51
 (MedDRA:10054008) Delayed closure of cranial sutures 2 / 7739
52
 (OMIM) Fingertip rounding 1 / 7739
53
 (HPO:0000963) Thin skin 96 / 7739
54
 (OMIM) Soft tissue calcinosis 1 / 7739
55
 (OMIM) Alopecia, partial 4 / 7739
56
 (OMIM) Sparse, lusterless scalp hair 1 / 7739
57
 (MedDRA:10053857) Partial lipodystrophy 8 / 7739
58
 (OMIM) Normal or increased truncal adipose tissue 1 / 7739
59
 (OMIM) Soft tissue or tendinous calcinosis may occur 1 / 7739
60
 (HPO:0000606) Abnormality of the periorbital region Occasional [Orphanet] 96 / 7739
61
 (HPO:0003011) Abnormality of the musculature Occasional [Orphanet] 47 / 7739