|
1
|
(HPO:0000716)
|
Depression |
|
|
|
|
99 / 7739
|
|
2
|
(HPO:0000727)
|
Frontal lobe dementia |
|
|
|
|
6 / 7739
|
|
3
|
(HPO:0001257)
|
Spasticity |
|
|
|
|
251 / 7739
|
|
4
|
(HPO:0001347)
|
Hyperreflexia |
|
|
|
|
363 / 7739
|
|
5
|
(HPO:0002063)
|
Rigidity |
|
|
|
|
92 / 7739
|
|
6
|
(HPO:0002067)
|
Bradykinesia |
|
|
|
|
62 / 7739
|
|
7
|
(HPO:0002171)
|
Gliosis |
|
|
|
|
48 / 7739
|
|
8
|
(HPO:0002172)
|
Postural instability |
|
|
|
|
22 / 7739
|
|
9
|
(HPO:0002186)
|
Apraxia |
|
|
|
|
22 / 7739
|
|
10
|
(HPO:0002300)
|
Mutism |
|
|
|
|
28 / 7739
|
|
11
|
(HPO:0002354)
|
Memory impairment |
|
|
|
|
63 / 7739
|
|
12
|
(HPO:0002362)
|
Shuffling gait |
|
|
|
|
13 / 7739
|
|
13
|
(HPO:0002500)
|
Abnormality of the cerebral white matter |
|
|
|
|
73 / 7739
|
|
14
|
(HPO:0002529)
|
Neuronal loss in central nervous system |
|
|
|
|
37 / 7739
|
|
15
|
(HPO:0007305)
|
CNS demyelination |
|
|
|
|
21 / 7739
|
|
16
|
(HPO:0001268)
|
Mental deterioration |
|
|
|
|
88 / 7739
|
|
17
|
(HPO:0000726)
|
Dementia |
|
|
|
|
131 / 7739
|
|
18
|
(OMIM)
|
Brain imaging shows deep white matter lesions, particularly affecting the frontal and parietal lobes |
|
|
|
|
1 / 7739
|
|
19
|
(OMIM)
|
Brain tissue shows myelin loss |
|
|
|
|
1 / 7739
|
|
20
|
(OMIM)
|
Axonal spheroids |
|
|
|
|
2 / 7739
|
|
21
|
(OMIM)
|
Spheroids contain neurofilaments |
|
|
|
|
1 / 7739
|
|
22
|
(OMIM)
|
Astrocytes |
|
|
|
|
1 / 7739
|
|
23
|
(OMIM)
|
Ballooned neurons |
|
|
|
|
2 / 7739
|
|
24
|
(MedDRA:10016759)
|
Flat affect |
|
|
|
|
1 / 7739
|
|
25
|
(MedDRA:10070246)
|
Executive dysfunction |
|
|
|
|
6 / 7739
|
|
26
|
(HPO:0000708)
|
Behavioral abnormality |
|
|
|
|
212 / 7739
|
|
27
|
(HPO:0000006)
|
Autosomal dominant inheritance |
|
|
|
|
2518 / 7739
|
|
28
|
(HPO:0002352)
|
Leukoencephalopathy |
|
|
|
|
32 / 7739
|
|
29
|
(HPO:0003581)
|
Adult onset |
|
|
|
|
117 / 7739
|
|
30
|
(HPO:0003678)
|
Rapidly progressive |
|
|
|
|
33 / 7739
|