PREECLAMPSIA/ECLAMPSIA 1

General Information (adopted from Orphanet):

Synonyms, Signs: TOXEMIA OF PREGNANCY HYPERTENSION, PREGNANCY-INDUCED, INCLUDED
HEMOLYSIS, ELEVATED LIVER ENZYMES, AND LOW PLATELET COUNT, INCLUDED
HELLP, INCLUDED
PEE1
PEE
PREG1
Number of Symptoms 9
OrphanetNr:
OMIM Id: 189800
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000093) Proteinuria 169 / 7739
2
(HPO:0001327) Photomyoclonic seizures 125 / 7739
3
(HPO:0001250) Seizures 1245 / 7739
4
(HPO:0008071) Maternal hypertension 6 / 7739
5
(HPO:0100602) Preeclampsia 9 / 7739
6
(HPO:0002910) Elevated hepatic transaminases 158 / 7739
7
(HPO:0001511) Intrauterine growth retardation 358 / 7739
8
(HPO:0001873) Thrombocytopenia 224 / 7739
9
(HPO:0000969) Edema 117 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Preeclampsia, which along with chronic hypertension and gestational hypertension comprise the hypertensive disorders of pregnancy, is characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. Preeclampsia is 1 of ...
Molecular genetics OMIM In 627 families with preeclampsia (including 398 maternal triads and 536 fetal triads), the GOPEC Consortium (2005) analyzed 7 candidate genes previously reported as conferring susceptibility to preeclampsia: angiotensinogen (AGT; 106150), the angiotensin receptors AGTR1 (106165) and AGTR2 ...
Population genetics OMIM Preeclampsia complicates 3 to 8% of pregnancies in Western countries and causes 10 to 15% of maternal deaths. Incidence ranges from 3 to 7% for nulliparas and 1 to 3% for multiparas (summary by Uzan et al., 2011). ...