Thymoma

General Information (adopted from Orphanet):

Synonyms, Signs: THYMIC NEOPLASIA
Primary thymic epithelial tumor
Primary thymic epithelial neoplasm
Number of Symptoms 36
OrphanetNr: 99867
OMIM Id: 274230
ICD-10: C37
D15.0
UMLs: C0040100
MeSH: D013945
MedDRA: 10043670
Snomed: 128856005
444231005

Prevalence, inheritance and age of onset:

Prevalence: 1.22 of 100 000 [Orphanet]
Inheritance: Not applicable
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Thymic epithelial neoplasm
 -Rare oncologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0000100) Nephrotic syndrome Occasional [Orphanet] 83 / 7739
2
 (HPO:0000217) Xerostomia Occasional [Orphanet] 35 / 7739
3
 (HPO:0001097) Keratoconjunctivitis sicca Occasional [Orphanet] 25 / 7739
4
 (HPO:0000651) Diplopia Frequent [Orphanet] 37 / 7739
5
 (HPO:0000508) Ptosis Frequent [Orphanet] 459 / 7739
6
 (HPO:0003473) Fatigable weakness Frequent [Orphanet] 39 / 7739
7
 (HPO:0002015) Dysphagia Frequent [Orphanet] 301 / 7739
8
 (HPO:0100006) Neoplasm of the central nervous system Occasional [Orphanet] 34 / 7739
9
 (HPO:0001578) Hypercortisolism Occasional [Orphanet] 17 / 7739
10
 (HPO:0100646) Thyroiditis Occasional [Orphanet] 11 / 7739
11
 (HPO:0100769) Synovitis Occasional [Orphanet] 86 / 7739
12
 (HPO:0001387) Joint stiffness Occasional [Orphanet] 322 / 7739
13
 (HPO:0100749) Chest pain Frequent [Orphanet] 92 / 7739
14
 (HPO:0010622) Neoplasm of the skeletal system Occasional [Orphanet] 30 / 7739
15
 (HPO:0002896) Neoplasm of the liver Occasional [Orphanet] 17 / 7739
16
 (HPO:0002585) Abnormality of the peritoneum Occasional [Orphanet] 9 / 7739
17
 (HPO:0001596) Alopecia Occasional [Orphanet] 162 / 7739
18
 (HPO:0000988) Skin rash Occasional [Orphanet] 98 / 7739
19
 (HPO:0001697) Abnormality of the pericardium Occasional [Orphanet] 52 / 7739
20
 (HPO:0001637) Abnormality of the myocardium Occasional [Orphanet] 76 / 7739
21
 (HPO:0001876) Pancytopenia Occasional [Orphanet] 89 / 7739
22
 (HPO:0004332) Abnormality of lymphocytes Very frequent [Orphanet] 12 / 7739
23
 (HPO:0010701) Abnormal immunoglobulin level Occasional [Orphanet] 49 / 7739
24
 (HPO:0001878) Hemolytic anemia Occasional [Orphanet] 83 / 7739
25
 (HPO:0002103) Abnormality of the pleura Occasional [Orphanet] 58 / 7739
26
 (HPO:0002093) Respiratory insufficiency Frequent [Orphanet] 410 / 7739
27
 (HPO:0100526) Neoplasm of the lung Occasional [Orphanet] 26 / 7739
28
 (HPO:0100522) Thymoma 5 / 7739
29
 (HPO:0100521) Neoplasm of the thymus Very frequent [Orphanet] 7 / 7739
30
 (HPO:0002716) Lymphadenopathy Frequent [Orphanet] 129 / 7739
31
 (HPO:0010515) Aplasia/Hypoplasia of the thymus Occasional [Orphanet] 17 / 7739
32
 (HPO:0001324) Muscle weakness Frequent [Orphanet] 859 / 7739
33
 (HPO:0100614) Myositis Occasional [Orphanet] 21 / 7739
34
 (HPO:0045026) Abnormality of the mediastinum Very frequent [Orphanet] 6 / 7739
35
 (HPO:0000007) Autosomal recessive inheritance 2538 / 7739
36
 ([DEL]MedDRA:10011224) Cough Frequent [Orphanet] 70 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Thymomas are low-grade epithelial cancers of the thymus. Familial occurrence of thymoma is rare.
Clinical Description OMIM Matani and Dristsas (1973) reported a Greek sibship of 3, demonstrating familial occurrence of thymoma. One of the 3 sibs, a 2-year-old girl, died of respiratory insufficiency resulting from a lymphocytic thymoma. Her 9-month-old brother died 2 years ...
Population genetics OMIM Nicodeme et al. (2005) stated that familial thymoma has a prevalence of 0.1 to 0.4 per 100,000.