Dengue fever

General Information (adopted from Orphanet):

Synonyms, Signs: DENGUE SHOCK SYNDROME, SUSCEPTIBILITY TO, INCLUDED
DENGUE HEMORRHAGIC FEVER, SUSCEPTIBILITY TO, INCLUDED
DENGUE FEVER, PROTECTION AGAINST, INCLUDED
DHF
DF
Dengue hemorrhagic fever
Dengue shock syndrome
Dengue virus infection
Number of Symptoms 23
OrphanetNr: 99828
OMIM Id: 614371
ICD-10: A90
UMLs:
MeSH: D003715
MedDRA:
Snomed: 38362002

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset: All ages
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Arbovirus fever
 -Rare infectious disease

Symptom Information: Sort by abundance 

1
 (HPO:0000225) Gingival bleeding Occasional [Orphanet] 28 / 7739
2
 (HPO:0000421) Epistaxis Occasional [Orphanet] 85 / 7739
3
 (HPO:0004372) Reduced consciousness/confusion Occasional [Orphanet] 73 / 7739
4
 (HPO:0002315) Headache Very frequent [Orphanet] 175 / 7739
5
 (HPO:0005059) Arthralgia/arthritis Frequent [Orphanet] 141 / 7739
6
 (HPO:0001541) Ascites Occasional [Orphanet] 94 / 7739
7
 (HPO:0002014) Diarrhea Occasional [Orphanet] 225 / 7739
8
 (HPO:0002017) Nausea and vomiting Occasional [Orphanet] 134 / 7739
9
 (HPO:0002240) Hepatomegaly Occasional [Orphanet] 467 / 7739
10
 (HPO:0002239) Gastrointestinal hemorrhage Occasional [Orphanet] 97 / 7739
11
 (HPO:0002027) Abdominal pain Frequent [Orphanet] 184 / 7739
12
 (HPO:0001933) Subcutaneous hemorrhage Occasional [Orphanet] 50 / 7739
13
 (HPO:0000989) Pruritus Frequent [Orphanet] 111 / 7739
14
 (HPO:0000988) Skin rash Frequent [Orphanet] 98 / 7739
15
 (HPO:0000978) Bruising susceptibility Occasional [Orphanet] 123 / 7739
16
 (HPO:0001695) Cardiac arrest Occasional [Orphanet] 87 / 7739
17
 (HPO:0002170) Intracranial hemorrhage Occasional [Orphanet] 40 / 7739
18
 (HPO:0002615) Hypotension Occasional [Orphanet] 52 / 7739
19
 (HPO:0001882) Leukopenia Occasional [Orphanet] 51 / 7739
20
 (HPO:0001873) Thrombocytopenia Occasional [Orphanet] 224 / 7739
21
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
22
 (HPO:0003075) Hypoproteinemia Occasional [Orphanet] 27 / 7739
23
 (HPO:0001522) Death in infancy Occasional [Orphanet] 275 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Dengue virus is a flavivirus belonging to the family Flaviviridae. Its principal vector is Aedes aegypti, a highly urbanized, daytime-biting mosquito that breeds in stored water. There are 4 antigenetically variant serotypes of dengue virus, DEN-1 to DEN-4, ...
Molecular genetics OMIM Sakuntabhai et al. (2005) found that a CD209 promoter polymorphism, -336A-G (604672.0001), was associated with severity of dengue disease. Specifically, the G allele of the variant was associated with strong protection against dengue fever, but not against dengue ...