Lyell syndrome

General Information (adopted from Orphanet):

Synonyms, Signs:
Number of Symptoms 41
OrphanetNr: 537
OMIM Id:
ICD-10: L51.2
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: All ages
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Toxic epidermal necrolysis
 -Rare skin disease

Symptom Information: Sort by abundance 

1
 (HPO:0000795) Abnormality of the urethra Occasional [Orphanet] 38 / 7739
2
 (HPO:0011037) Decreased urine output Frequent [Orphanet] 47 / 7739
3
 (HPO:0000142) Abnormality of the vagina Occasional [Orphanet] 24 / 7739
4
 (HPO:0000083) Renal insufficiency Occasional [Orphanet] 232 / 7739
5
 (HPO:0000492) Abnormality of the eyelid Occasional [Orphanet] 41 / 7739
6
 (HPO:0003781) Excessive salivation Frequent [Orphanet] 15 / 7739
7
 (HPO:0011830) Abnormality of oral mucosa Very frequent [Orphanet] 47 / 7739
8
 (HPO:0000481) Abnormality of the cornea Occasional [Orphanet] 124 / 7739
9
 (HPO:0000613) Photophobia Occasional [Orphanet] 158 / 7739
10
 (HPO:0000572) Visual loss Occasional [Orphanet] 272 / 7739
11
 (HPO:0100533) Inflammatory abnormality of the eye Occasional [Orphanet] 70 / 7739
12
 (HPO:0002015) Dysphagia Very frequent [Orphanet] 301 / 7739
13
 (HPO:0002910) Elevated hepatic transaminases Frequent [Orphanet] 158 / 7739
14
 (HPO:0001733) Pancreatitis Occasional [Orphanet] 46 / 7739
15
 (HPO:0006554) Acute hepatic failure Occasional [Orphanet] 20 / 7739
16
 (HPO:0002239) Gastrointestinal hemorrhage Occasional [Orphanet] 97 / 7739
17
 (HPO:0002242) Abnormality of the intestine Occasional [Orphanet] 42 / 7739
18
 (HPO:0002017) Nausea and vomiting Occasional [Orphanet] 134 / 7739
19
 (HPO:0002575) Tracheoesophageal fistula Occasional [Orphanet] 54 / 7739
20
 (HPO:0002027) Abdominal pain Frequent [Orphanet] 184 / 7739
21
 (HPO:0002024) Malabsorption Frequent [Orphanet] 142 / 7739
22
 (HPO:0004325) Decreased body weight Very frequent [Orphanet] 492 / 7739
23
 (HPO:0200042) Skin ulcer Occasional [Orphanet] 138 / 7739
24
 (HPO:0100792) Acantholysis Very frequent [Orphanet] 11 / 7739
25
 (HPO:0200037) Skin vesicle Very frequent [Orphanet] 102 / 7739
26
 (HPO:0010783) Erythema Very frequent [Orphanet] 138 / 7739
27
 (HPO:0001677) Coronary artery disease Occasional [Orphanet] 58 / 7739
28
 (HPO:0001695) Cardiac arrest Occasional [Orphanet] 87 / 7739
29
 (HPO:0001637) Abnormality of the myocardium Occasional [Orphanet] 76 / 7739
30
 (HPO:0001874) Abnormality of neutrophils Very frequent [Orphanet] 47 / 7739
31
 (HPO:0001873) Thrombocytopenia Very frequent [Orphanet] 224 / 7739
32
 (HPO:0001903) Anemia Frequent [Orphanet] 289 / 7739
33
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
34
 (HPO:0002093) Respiratory insufficiency Occasional [Orphanet] 410 / 7739
35
 (HPO:0002103) Abnormality of the pleura Occasional [Orphanet] 58 / 7739
36
 (HPO:0002091) Restrictive ventilatory defect Occasional [Orphanet] 46 / 7739
37
 (HPO:0002205) Recurrent respiratory infections Frequent [Orphanet] 254 / 7739
38
 (HPO:0100806) Sepsis Very frequent [Orphanet] 48 / 7739
39
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739
40
 (MedDRA:10025421) Macule Very frequent [Orphanet] 55 / 7739
41
 ([DEL]MedDRA:10011224) Cough Frequent [Orphanet] 70 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: