Arachnoiditis
General Information (adopted from Orphanet):
| Synonyms, Signs: |
Chronic arachnoiditis Adhesive arachnoiditis |
| Number of Symptoms | 23 |
| OrphanetNr: | 137817 |
| OMIM Id: |
182950
|
| ICD-10: |
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| UMLs: |
C0003708 |
| MeSH: |
D001100 |
| MedDRA: |
10003074 |
| Snomed: |
8217007 |
Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Not applicable [Orphanet] |
| Age of onset: |
All ages [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Rare neurologic disease
-Rare neurologic disease |
Symptom Information:
|
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(HPO:0002839) | Urinary bladder sphincter dysfunction | Occasional [Orphanet] | 34 / 7739 | |||
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(HPO:0000478) | Abnormality of the eye | Very frequent [Orphanet] | 126 / 7739 | |||
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(HPO:0000360) | Tinnitus | Very frequent [Orphanet] | 29 / 7739 | |||
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(HPO:0000598) | Abnormality of the ear | Very frequent [Orphanet] | 98 / 7739 | |||
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(HPO:0000365) | Hearing impairment | Very frequent [Orphanet] | 539 / 7739 | |||
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(HPO:0011442) | Abnormality of central motor function | Very frequent [Orphanet] | 76 / 7739 | |||
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(HPO:0000763) | Sensory neuropathy | Very frequent [Orphanet] | 78 / 7739 | |||
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(HPO:0003474) | Sensory impairment | Very frequent [Orphanet] | 54 / 7739 | |||
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(HPO:0002313) | Spastic paraparesis | 33 / 7739 | ||||
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(HPO:0001315) | Reduced tendon reflexes | Very frequent [Orphanet] | 160 / 7739 | |||
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(HPO:0001287) | Meningitis | Very frequent [Orphanet] | 46 / 7739 | |||
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(HPO:0002315) | Headache | Occasional [Orphanet] | 175 / 7739 | |||
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(HPO:0005059) | Arthralgia/arthritis | Very frequent [Orphanet] | 141 / 7739 | |||
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(HPO:0000924) | Abnormality of the skeletal system | 114 / 7739 | ||||
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(HPO:0001939) | Abnormality of metabolism/homeostasis | 328 / 7739 | ||||
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(HPO:0004370) | Abnormality of temperature regulation | Frequent [Orphanet] | 58 / 7739 | |||
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(HPO:0001324) | Muscle weakness | Very frequent [Orphanet] | 859 / 7739 | |||
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(HPO:0000238) | Hydrocephalus | Occasional [Orphanet] | 278 / 7739 | |||
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(OMIM) | Multiple filling defects on myelography | 1 / 7739 | ||||
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(HPO:0000006) | Autosomal dominant inheritance | 2518 / 7739 | ||||
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(OMIM) | Patchy numbness | 1 / 7739 | ||||
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(MedDRA:10059604) | Radicular pain | 1 / 7739 | ||||
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(OMIM) | Band-like fibrous thickening of spinal arachnoid | 1 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|
Additional Information:
| Clinical Description OMIM |
Duke and Hashimoto (1974) described a Canadian kindred of Japanese ancestry in which 6 members of 3 generations had adult onset of progressive spastic paraparesis with prominent radicular pain and patchy numbness. Myelography showed obstruction to flow of ... |