Hairy cell leukemia variant

General Information (adopted from Orphanet):

Synonyms, Signs: Prolymphocytic variant of hairy cell leukemia
HCL-v
Leukemic reticuloendotheliosis variant
Prolymphocytic variant of HCL
Number of Symptoms 25
OrphanetNr: 300878
OMIM Id:
ICD-10: C91.4
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Indolent B-cell non-Hodgkin lymphoma
 -Rare hematologic disease
 -Rare oncologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0100787) Prostate neoplasm Occasional [Orphanet] 3 / 7739
2
 (HPO:0000083) Renal insufficiency Occasional [Orphanet] 232 / 7739
3
 (HPO:0002910) Elevated hepatic transaminases Occasional [Orphanet] 158 / 7739
4
 (HPO:0002027) Abdominal pain Very frequent [Orphanet] 184 / 7739
5
 (HPO:0001744) Splenomegaly Very frequent [Orphanet] 337 / 7739
6
 (HPO:0000988) Skin rash Occasional [Orphanet] 98 / 7739
7
 (HPO:0001031) Subcutaneous lipoma Occasional [Orphanet] 112 / 7739
8
 (HPO:0012089) Arteritis Occasional [Orphanet] 40 / 7739
9
 (HPO:0001635) Congestive heart failure Occasional [Orphanet] 232 / 7739
10
 (HPO:0003010) Prolonged bleeding time Occasional [Orphanet] 88 / 7739
11
 (HPO:0001876) Pancytopenia Occasional [Orphanet] 89 / 7739
12
 (HPO:0001909) Leukemia Very frequent [Orphanet] 46 / 7739
13
 (HPO:0100827) Lymphocytosis Frequent [Orphanet] 5 / 7739
14
 (HPO:0001974) Leukocytosis Very frequent [Orphanet] 33 / 7739
15
 (HPO:0012145) Abnormality of multiple cell lineages in the bone marrow Very frequent [Orphanet] 11 / 7739
16
 (HPO:0001903) Anemia Frequent [Orphanet] 289 / 7739
17
 (HPO:0004311) Abnormality of macrophages Occasional [Orphanet] 7 / 7739
18
 (HPO:0001878) Hemolytic anemia Occasional [Orphanet] 83 / 7739
19
 (HPO:0100526) Neoplasm of the lung Occasional [Orphanet] 26 / 7739
20
 (HPO:0002093) Respiratory insufficiency Very frequent [Orphanet] 410 / 7739
21
 (HPO:0002664) Neoplasm Occasional [Orphanet] 111 / 7739
22
 (HPO:0010978) Abnormality of immune system physiology Very frequent [Orphanet] 148 / 7739
23
 (HPO:0002716) Lymphadenopathy Occasional [Orphanet] 129 / 7739
24
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739
25
 (MedDRA:10025421) Macule Occasional [Orphanet] 55 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: