HSC
HSC-Explorer
Immunostaining of hematopoietic stem and progenitor cells: CD45-a488 (green), sca1a555 (blue), cKita647 (white) (provided by Dirk Loeffler).
About HSC-Explorer
HSC-Explorer is a manually curated integrative
bioinformatics resource based on semantic search and ontologies
that allow to effectively search biological pathways relevant to
hematopoiesis.
Specifically, the database currently
covers the early steps of differentiation from the most primitive
hematopoietic stem cells (LT-HSC) to the more differentiated
progenitor cells (ST-HSC and MPP). Curated literature information
about the different hematopoietic stem cell subpopulations
published so far and their behavior in repopulation activity,
self-renewal and quiescence and how these processes are regulated
by intrinsic and extrinsic factors is provided.
Through
an effective query function relevant information can be easily
extracted and the data can be graphically visualized.
We
constantly work on expanding the current database to ultimately
cover all hematopoietic progenitor populations.
The aim
of HSC-Explorer is to serve as a knowledge base for
experimentally-oriented scientists and as a resource for
bioinformatics applications.
General Statistics
| Number and list of articles: | 217 |
| 7607 | |
| 388 |
Interaction Statistics
| Proteins/Genes | Bioprocesses | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Selected Topics:
- Colocalization of HSCs and stromal cells
- Comparison of expression profiles of long-term-repopulating HSCs
- Cxcl12/Cxcr4 signaling
- Extrinsic factors
- Hypoxia vs. oxidative stress
- Notch signaling
- Quiescence, a selection of genes, processes and extrinsic factors known to affect HSC quiescence
- Self-renewal activity, a selection of genes, processes and extrinsic factors known to affect HSC self-renewal activity
- The Hematopoietic stem cell niche, an overview
- Tie2/Ang1 signaling
Help
- How to query HSC?
Default query: By default all interactions in all categories are searched. Queries are not ... - Visualization of data in HSC
On the graphical output all categories, such as immunophenotype, biological processes or genes/proteins are displayed ... - Origin of the data in HSC
Data in HSC-Explorer are retrieved from scientific articles and are linked to the respective PubMed ... - Curation of data in HSC
General information includes the literature reference (PubMed-ID) and information about the organism (strain, gender ...
Statistics
| Tissue/cell line (niche) | Immunophenotype (blood cell type) | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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