| 21211783 |
Smith-Berdan S et al.:
Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches.
Cell Stem Cell
2011
8: 72-83
|
| 19062086 |
Wilson A et al.:
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair.
Cell
2008
135: 1118-1129
|
| 19062086 |
Wilson A et al.:
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
Cell
2008
135: 1118-1129
|
| 20074534 |
Benveniste P et al.:
Intermediate-term hematopoietic stem cells with extended but time-limited reconstitution potential.
Cell Stem Cell
2010
6: 48-58
|
| 15989959 |
Kiel MJ et al.:
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells.
Cell
2005
121: 1109-1121
|
| 15989959 |
Kiel MJ et al.:
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells.
Cell
2005
121: 1109-1121
|
| 15989959 |
Kiel MJ et al.:
SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
Cell
2005
121: 1109-1121
|
| 19377048 |
Kent DG et al.:
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential.
Blood
2009
113: 6342-6350
|
| 19377048 |
Kent DG et al.:
Prospective isolation and molecular characterization of hematopoietic stem cells with durable self-renewal potential
Blood
2009
113: 6342-6350
|
| 18371352 |
Dykstra B et al.:
Long-term propagation of distinct hematopoietic differentiation programs in vivo.
Cell Stem Cell
2007
1: 218-229
|
| 20207229 |
Challen GA et al.:
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1
Cell Stem Cell
2010
6: 265-278
|
| 19379700 |
Deneault E et al.:
A functional screen to identify novel effectors of hematopoietic stem cell activity.
Cell
2009
137: 369-379
|
| 21478879 |
Rathinam C et al.:
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells.
Nat. Immunol.
2011
12: 399-407
|
| 21478879 |
Rathinam C et al.:
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells
Nat. Immunol.
2011
12: 399-407
|
| 16151515 |
Forsberg EC et al.:
Differential expression of novel potential regulators in hematopoietic stem cells.
PLoS Genet.
2005
1: E28
|
| 16151515 |
Forsberg EC et al.:
Differential expression of novel potential regulators in hematopoietic stem cells
PLoS Genet.
2005
1: E28
|
| 12228720 |
Ramalho-Santos M et al.:
Stemness: transcriptional profiling of embryonic and adult stem cells
Science
2002
298: 597-600
|
| 12228720 |
Ramalho-Santos M et al.:
Stemness: transcriptional profiling of embryonic and adult stem cells
Science
2002
298: 597-600
|
| 12228721 |
Ivanova NB et al.:
A stem cell molecular signature.
Science
2002
298: 601-604
|
| 15459755 |
Venezia TA et al.:
Molecular signatures of proliferation and quiescence in hematopoietic stem cells.
PLoS Biol.
2004
2: E301
|
| 15459755 |
Venezia TA et al.:
Molecular signatures of proliferation and quiescence in hematopoietic stem cells
PLoS Biol.
2004
2: E301
|
| 12228721 |
Ivanova NB et al.:
A stem cell molecular signature
Science
2002
298: 601-604
|
| 18371395 |
Chambers SM et al.:
Hematopoietic fingerprints: an expression database of stem cells and their progeny.
Cell Stem Cell
2007
1: 578-591
|
| 18371395 |
Chambers SM et al.:
Hematopoietic fingerprints: an expression database of stem cells and their progeny
Cell Stem Cell
2007
1: 578-591
|
| 18371395 |
Chambers SM et al.:
Hematopoietic fingerprints: an expression database of stem cells and their progeny
Cell Stem Cell
2007
1: 578-591
|
| 18371409 |
Yoshihara H et al.:
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.
Cell Stem Cell
2007
1: 685-697
|
| 18371409 |
Yoshihara H et al.:
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
Cell Stem Cell
2007
1: 685-697
|
| 18371408 |
Qian H et al.:
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells.
Cell Stem Cell
2007
1: 671-684
|
| 9448308 |
Kimura S et al.:
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.
Proc. Natl. Acad. Sci. U.S.A.
1998
95: 1195-1200
|
| 15260986 |
Arai F et al.:
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.
Cell
2004
118: 149-161
|
| 18618018 |
Bersenev A et al.:
Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2.
J. Clin. Invest.
2008
118: 2832-2844
|
| 15254242 |
Kirito K et al.:
Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cells.
Mol. Cell. Biol.
2004
24: 6751-6762
|
| 17284614 |
Seita J et al.:
Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction.
Proc. Natl. Acad. Sci. U.S.A.
2007
104: 2349-2354
|
| 12163458 |
Fox N et al.:
Thrombopoietin expands hematopoietic stem cells after transplantation.
J. Clin. Invest.
2002
110: 389-394
|
| 14574412 |
Zhang J et al.:
Identification of the haematopoietic stem cell niche and control of the niche size.
Nature
2003
425: 836-841
|
| 20850355 |
Omatsu Y et al.:
The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche.
Immunity
2010
33: 387-399
|
| 17174120 |
Sugiyama T et al.:
Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches
Immunity
2006
25: 977-988
|
| 14574413 |
Calvi LM et al.:
Osteoblastic cells regulate the haematopoietic stem cell niche.
Nature
2003
425: 841-846
|
| 20631378 |
Grassinger J et al.:
Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biologic potential.
Blood
2010
116: 3185-3196
|
| 19052548 |
Xie Y et al.:
Detection of functional haematopoietic stem cell niche using real-time imaging
Nature
2009
457: 97-101
|
| 18371452 |
Fleming HE et al.:
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo.
Cell Stem Cell
2008
2: 274-283
|
| 20472830 |
Nakamura Y et al.:
Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
Blood
2010
116: 1422-1432
|
| 19759357 |
Goldman DC et al.:
BMP4 regulates the hematopoietic stem cell niche.
Blood
2009
114: 4393-4401
|
| 20887955 |
Kieslinger M et al.:
Early B cell factor 2 regulates hematopoietic stem cell homeostasis in a cell-nonautonomous manner.
Cell Stem Cell
2010
7: 496-507
|
| 21652676 |
Schaniel C et al.:
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
Blood
2011
118: 2420-2429
|
| 21652676 |
Schaniel C et al.:
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells.
Blood
2011
118: 2420-2429
|
| 15845900 |
Nilsson SK et al.:
Osteopontin, a key component of the hematopoietic stem cell niche and regulator of primitive hematopoietic progenitor cells.
Blood
2005
106: 1232-1239
|
| 19417209 |
Grassinger J et al.:
Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins.
Blood
2009
114: 49-59
|
| 12393456 |
Nilsson SK et al.:
Hyaluronan is synthesized by primitive hemopoietic cells, participates in their lodgment at the endosteum following transplantation, and is involved in the regulation of their proliferation and differentiation in vitro.
Blood
2003
101: 856-862
|
| 19797522 |
Lewandowski D et al.:
In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution.
Blood
2010
115: 443-452
|
| 21179442 |
Pillai MM et al.:
MiR-886-3p down regulates CXCL12 (SDF1) expression in human marrow stromal cells.
PLoS ONE
2010
5
|
| 16382241 |
Adams GB et al.:
Stem cell engraftment at the endosteal niche is specified by the calcium-sensing receptor.
Nature
2006
439: 599-603
|
| 21670467 |
Rehn M et al.:
Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche.
Blood
2011
118: 1534-1543
|
| 1346154 |
Uchida N et al.:
Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.
J. Exp. Med.
1992
175: 175-184
|
| 1717068 |
Okada S et al.:
Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule.
Blood
1991
78: 1706-1712
|
| 1281687 |
Okada S et al.:
In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.
Blood
1992
80: 3044-3050
|
| 7911343 |
Uchida N et al.:
Rapid and sustained hematopoietic recovery in lethally irradiated mice transplanted with purified Thy-1.1lo Lin-Sca-1+ hematopoietic stem cells.
Blood
1994
83: 3758-3779
|
| 14738767 |
Matsuzaki Y et al.:
Unexpectedly efficient homing capacity of purified murine hematopoietic stem cells
Immunity
2004
20: 87-93
|
| 11672547 |
Adolfsson J et al.:
Upregulation of Flt3 expression within the bone marrow Lin(-)Sca1(+)c-kit(+) stem cell compartment is accompanied by loss of self-renewal capacity.
Immunity
2001
15: 659-669
|
| 8666936 |
Goodell MA et al.:
Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.
J. Exp. Med.
1996
183: 1797-1806
|
| 7541305 |
Morrison SJ et al.:
The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype.
Immunity
1994
1: 661-673
|
| 1371359 |
Ikuta K et al.:
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.
Proc. Natl. Acad. Sci. U.S.A.
1992
89: 1502-1506
|
| 1371359 |
Ikuta K et al.:
Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation
Proc. Natl. Acad. Sci. U.S.A.
1992
89: 1502-1506
|
| 14976059 |
Muller-Sieburg CE et al.:
Myeloid-biased hematopoietic stem cells have extensive self-renewal capacity but generate diminished lymphoid progeny with impaired IL-7 responsiveness.
Blood
2004
103: 4111-4118
|
| 17379664 |
Bowie MB et al.:
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.
Proc. Natl. Acad. Sci. U.S.A.
2007
104: 5878-5882
|
| 17379664 |
Bowie MB et al.:
Identification of a new intrinsically timed developmental checkpoint that reprograms key hematopoietic stem cell properties.
Proc. Natl. Acad. Sci. U.S.A.
2007
104: 5878-5882
|
| 20421392 |
Morita Y et al.:
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment.
J. Exp. Med.
2010
207: 1173-1182
|
| 12393558 |
Akashi K et al.:
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis.
Blood
2003
101: 383-389
|
| 12393558 |
Akashi K et al.:
Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis
Blood
2003
101: 383-389
|
| 17676974 |
Chambers SM et al.:
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation.
PLoS Biol.
2007
5: E201
|
| 17676974 |
Chambers SM et al.:
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation
PLoS Biol.
2007
5: E201
|
| 20098702 |
Forsberg EC et al.:
Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells
PLoS ONE
2010
5: E8785
|
| 19050837 |
Yashiro Y et al.:
Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing
Int. J. Hematol.
2009
89: 24-33
|
| 8662508 |
Osawa M et al.:
Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell.
Science
1996
273: 242-245
|
| 2898810 |
Spangrude GJ et al.:
Purification and characterization of mouse hematopoietic stem cells
Science
1988
241: 58-62
|
| 20207229 |
Challen GA et al.:
Distinct hematopoietic stem cell subtypes are differentially regulated by TGF-beta1.
Cell Stem Cell
2010
6: 265-278
|
| 19050837 |
Yashiro Y et al.:
Transcriptional profiling of hematopoietic stem cells by high-throughput sequencing.
Int. J. Hematol.
2009
89: 24-33
|
| 20161778 |
Li G et al.:
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5
PLoS ONE
2010
5: E9152
|
| 20161778 |
Li G et al.:
Gab2 promotes hematopoietic stem cell maintenance and self-renewal synergistically with STAT5.
PLoS ONE
2010
5: E9152
|
| 15589172 |
Iwama A et al.:
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1.
Immunity
2004
21: 843-851
|
| 12714971 |
Park IK et al.:
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Nature
2003
423: 302-305
|
| 12393407 |
Bradley HL et al.:
Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.
Blood
2002
100: 3983-3989
|
| 19258595 |
Wang Z et al.:
Conditional deletion of STAT5 in adult mouse hematopoietic stem cells causes loss of quiescence and permits efficient nonablative stem cell replacement.
Blood
2009
113: 4856-4865
|
| 22290873 |
Zhao C et al.:
Noncanonical NF-kappaB signaling regulates hematopoietic stem cell self-renewal and microenvironment interactions
Stem Cells
2012
30: 709-718
|
| 22072554 |
Bungartz G et al.:
NF-Y is necessary for hematopoietic stem cell proliferation and survival
Blood
2012
119: 1380-1389
|
| 22072554 |
Bungartz G et al.:
NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Blood
2012
119: 1380-1389
|
| 15545632 |
Wilson A et al.:
c-Myc controls the balance between hematopoietic stem cell self-renewal and differentiation.
Genes Dev.
2004
18: 2747-2763
|
| 12062105 |
Heissig B et al.:
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand.
Cell
2002
109: 625-637
|
| 14662336 |
Driessen RL et al.:
Membrane-bound stem cell factor is a key regulator in the initial lodgment of stem cells within the endosteal marrow region
Exp. Hematol.
2003
31: 1284-1291
|
| 7687160 |
Bodine DM et al.:
In vivo administration of stem cell factor to mice increases the absolute number of pluripotent hematopoietic stem cells.
Blood
1993
82: 445-455
|
| 7544641 |
Keller JR et al.:
Steel factor (c-kit ligand) promotes the survival of hematopoietic stem/progenitor cells in the absence of cell division.
Blood
1995
86: 1757-1764
|
| 18250409 |
Thoren LA et al.:
Kit regulates maintenance of quiescent hematopoietic stem cells.
J. Immunol.
2008
180: 2045-2053
|
| 10710306 |
Cheng T et al.:
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
Science
2000
287: 1804-1808
|
| 11739168 |
Cheng T et al.:
Transforming growth factor beta 1 mediates cell-cycle arrest of primitive hematopoietic cells independent of p21(Cip1/Waf1) or p27(Kip1).
Blood
2001
98: 3643-3649
|
| 18951693 |
Malhotra S et al.:
Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells
Exp. Hematol.
2009
37: 19-30
|
| 7568190 |
Papayannopoulou T et al.:
The VLA4/VCAM-1 adhesion pathway defines contrasting mechanisms of lodgement of transplanted murine hemopoietic progenitors between bone marrow and spleen
Proc. Natl. Acad. Sci. U.S.A.
1995
92: 9647-9651
|
| 20703299 |
Mendez-Ferrer S et al.:
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
Nature
2010
466: 829-834
|
| 12091880 |
Hattori K et al.:
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment
Nat. Med.
2002
8: 841-849
|
| 22155722 |
Lu J et al.:
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion
Exp. Hematol.
2012
40: 307-317
|
| 12717450 |
Reya T et al.:
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Nature
2003
423: 409-414
|
| 7622039 |
Sauvageau G et al.:
Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
Genes Dev.
1995
9: 1753-1765
|
| 18371351 |
Kiel MJ et al.:
Lack of evidence that hematopoietic stem cells depend on N-cadherin-mediated adhesion to osteoblasts for their maintenance
Cell Stem Cell
2007
1: 204-217
|
| 20207221 |
Hosokawa K et al.:
Cadherin-based adhesion is a potential target for niche manipulation to protect hematopoietic stem cells in adult bone marrow
Cell Stem Cell
2010
6: 194-198
|
| 19415781 |
Nemeth MJ et al.:
beta-Catenin expression in the bone marrow microenvironment is required for long-term maintenance of primitive hematopoietic cells
Stem Cells
2009
27: 1109-1119
|
| 21931116 |
Wang J et al.:
The role of Skp2 in hematopoietic stem cell quiescence, pool size, and self-renewal
Blood
2011
20: 5429-5438
|
| 21502543 |
Rodriguez S et al.:
The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
Blood
2011
117: 6509-6519
|
| 21211783 |
Smith-Berdan S et al.:
Robo4 cooperates with CXCR4 to specify hematopoietic stem cell localization to bone marrow niches
Cell Stem Cell
2011
8: 72-83
|
| 18378795 |
Nie Y et al.:
CXCR4 is required for the quiescence of primitive hematopoietic cells
J. Exp. Med.
2008
205: 777-783
|
| 18927479 |
Shibata F et al.:
Roundabout 4 is expressed on hematopoietic stem cells and potentially involved in the niche-mediated regulation of the side population phenotype
Stem Cells
2009
27: 183-190
|
| 22654110 |
Goncharova V et al.:
Hyaluronan expressed by the hematopoietic microenvironment is required for bone marrow hematopoiesis
J. Biol. Chem.
2012
287
|
| 16439213 |
Katayama Y et al.:
Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow
Cell
2006
124: 407-421
|
| 21108988 |
Jung Y et al.:
Annexin-2 is a regulator of stromal cell-derived factor-1/CXCL12 function in the hematopoietic stem cell endosteal niche
Exp. Hematol.
2011
39: 151-166
|
| 17478585 |
Levesque JP et al.:
Hematopoietic progenitor cell mobilization results in hypoxia with increased hypoxia-inducible transcription factor-1 alpha and vascular endothelial growth factor A in bone marrow
Stem Cells
2007
25: 1954-1965
|
| 11571304 |
McQuibban GA et al.:
Matrix metalloproteinase activity inactivates the CXC chemokine stromal cell-derived factor-1
J. Biol. Chem.
2001
276
|
| 20959605 |
Zheng J et al.:
Angiopoietin-like protein 3 supports the activity of hematopoietic stem cells in the bone marrow niche
Blood
2011
117: 470-479
|
| 11895769 |
Stier S et al.:
Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome
Blood
2002
99: 2369-2378
|
| 12406868 |
Kunisato A et al.:
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo
Blood
2003
101: 1777-1783
|
| 15550486 |
Mancini SJ et al.:
Jagged1-dependent Notch signaling is dispensable for hematopoietic stem cell self-renewal and differentiation
Blood
2005
105: 2340-2342
|
| 17574022 |
Walkley CR et al.:
Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
Cell
2007
129: 1081-1095
|
| 15654333 |
Walkley CR et al.:
Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells
Nat. Cell Biol.
2005
7: 172-178
|
| 16957735 |
Janzen V et al.:
Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a
Nature
2006
443: 421-426
|
| 22817897 |
Sugimura R et al.:
Noncanonical Wnt signaling maintains hematopoietic stem cells in the niche
Cell
2012
150: 351-365
|
| 22901259 |
Arai F et al.:
Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche
Ann. N. Y. Acad. Sci.
2012
1266: 72-77
|
| 22281595 |
Ding L et al.:
Endothelial and perivascular cells maintain haematopoietic stem cells
Nature
2012
481: 457-462
|
| 22267605 |
Ku CJ et al.:
GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry
Blood
2012
119: 2242-2251
|
| 19345332 |
Santaguida M et al.:
JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal
Cancer Cell
2009
15: 341-352
|
| 22039255 |
Kobayashi M et al.:
Regulation of murine hematopoietic stem cell quiescence by Dmtf1
Blood
2011
118: 6562-6571
|
| 21821709 |
Huynh H et al.:
IGF binding protein 2 supports the survival and cycling of hematopoietic stem cells
Blood
2011
118: 3236-3243
|
| 16968775 |
Trowbridge JJ et al.:
Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration
Proc. Natl. Acad. Sci. U.S.A.
2006
103
|
| 7568040 |
Zijlmans JM et al.:
Modification of rhodamine staining allows identification of hematopoietic stem cells with preferential short-term or long-term bone marrow-repopulating ability
Proc. Natl. Acad. Sci. U.S.A.
1995
92: 8901-8905
|
| 14563317 |
Chen CZ et al.:
The endoglin(positive) sca-1(positive) rhodamine(low) phenotype defines a near-homogeneous population of long-term repopulating hematopoietic stem cells
Immunity
2003
19: 525-533
|
| 7849289 |
Spangrude GJ et al.:
Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: in vivo expansion of stem cell phenotype but not function
Blood
1995
85: 1006-1016
|
| 12438646 |
Chen CZ et al.:
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
Proc. Natl. Acad. Sci. U.S.A.
2002
99
|
| 17983596 |
Umemoto T et al.:
CD61 enriches long-term repopulating hematopoietic stem cells
Biochem. Biophys. Res. Commun.
2008
365: 176-182
|
| 18371339 |
Miyamoto K et al.:
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
Cell Stem Cell
2007
1: 101-112
|
| 16565722 |
Ito K et al.:
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
Nat. Med.
2006
12: 446-451
|
| 21948176 |
Wang Y et al.:
Essential roles for Pot1b in HSC self-renewal and survival
Blood
2011
118: 6068-6077
|
| 21982233 |
Miharada K et al.:
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78
Cell Stem Cell
2011
9: 330-344
|
| 15928197 |
Stier S et al.:
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
J. Exp. Med.
2005
201: 1781-1791
|
| 20804974 |
Takubo K et al.:
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
Cell Stem Cell
2010
7: 391-402
|
| 18047833 |
Kubota Y et al.:
Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche
Biochem. Biophys. Res. Commun.
2008
366: 335-339
|
| 20972423 |
Kobayashi H et al.:
Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells
Nat. Cell Biol.
2010
12: 1046-1056
|
| 20207228 |
Butler JM et al.:
Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells
Cell Stem Cell
2010
6: 251-264
|
| 19516257 |
Naveiras O et al.:
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Nature
2009
460: 259-263
|
| 17360942 |
Jung Y et al.:
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantation
Blood
2007
110: 82-90
|
| 20305640 |
Raaijmakers MH et al.:
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
Nature
2010
464: 852-857
|
| 21131587 |
Lymperi S et al.:
Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo
Blood
2011
117: 1540-1549
|
| 22118468 |
Yamazaki S et al.:
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
Cell
2011
147: 1146-1158
|
| 21441933 |
Schajnovitz A et al. et al.:
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions
Nat. Immunol.
2011
12: 391-398
|
| 21441933 |
Schajnovitz A et al.:
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions
Nat. Immunol.
2011
12: 391-398
|
| 21653324 |
Mazzon C et al.:
The critical role of agrin in the hematopoietic stem cell niche
Blood
2011
118: 2733-2742
|
| 22983360 |
Ludin A et al.:
Monocytes-macrophages that express alpha-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow
Nat. Immunol.
2012
11: 1072-1082
|
| 21282381 |
Chow A et al.:
Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
J. Exp. Med.
2011
208: 261-271
|
| 20713966 |
Winkler IG et al.:
Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSCs
Blood
2010
116: 4815-4828
|
| 21115812 |
de Graaf CA et al.:
Regulation of hematopoietic stem cells by their mature progeny
Proc. Natl. Acad. Sci. U.S.A.
2010
107
|
| 20052668 |
Lemieux JM et al.:
Involvement of integrins alpha(3)beta(1) and alpha(5)beta(1) and glycoprotein IIb in megakaryocyte-induced osteoblast proliferation
J. Cell. Biochem.
2010
109: 927-932
|
| 18055867 |
Weksberg DC et al.:
CD150- side population cells represent a functionally distinct population of long-term hematopoietic stem cells
Blood
2008
111: 2444-2451
|
| 22138693 |
Challen GA et al.:
Dnmt3a is essential for hematopoietic stem cell differentiation
Nat. Genet.
2012
44: 23-31
|
| 22084405 |
Kataoka K et al.:
Evi1 is essential for hematopoietic stem cell self-renewal, and its expression marks hematopoietic cells with long-term multilineage repopulating activity
J. Exp. Med.
2011
208: 2403-2416
|
| 23091297 |
Unnisa Z et al.:
Meis1 preserves hematopoietic stem cells in mice by limiting oxidative stress
Blood
2012
120: 4973-4981
|
| 22606246 |
Nakamura S et al.:
Bmi1 confers resistance to oxidative stress on hematopoietic stem cells
PLoS ONE
2012
7
|
| 22039262 |
Merchant AA et al.:
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels
Blood
2011
118: 6572-6579
|
| 15496926 |
Ito K et al.:
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Nature
2004
431: 997-1002
|
| 20835244 |
Chuikov S et al.:
Prdm16 promotes stem cell maintenance in multiple tissues, partly by regulating oxidative stress
Nat. Cell Biol.
2010
12: 999-1006
|
| 23280653 |
Jeannet R et al.:
Alcam regulates long-term hematopoietic stem cell engraftment and self-renewal
Stem Cells
2013
31: 560-571
|
| 23142521 |
Lechman ER et al.:
Attenuation of miR-126 Activity Expands HSC In Vivo without Exhaustion
Cell Stem Cell
2012
11: 799-811
|
| 23290137 |
Yu WM et al.:
Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation
Cell Stem Cell
2013
12: 62-74
|
| 23226403 |
Goto-Koshino Y et al.:
Robo4 plays a role in bone marrow homing and mobilization, but is not essential in the long-term repopulating capacity of hematopoietic stem cells
PLoS ONE
2012
7
|
| 17897629 |
Hosokawa K et al.:
Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
Biochem. Biophys. Res. Commun.
2007
363: 578-583
|
| 21673348 |
Ellis SL et al.:
The relationship between bone, hemopoietic stem cells, and vasculature
Blood
2011
118: 1516-1524
|
| 21868569 |
Arcangeli ML et al.:
JAM-B regulates maintenance of hematopoietic stem cells in the bone marrow
Blood
2011
118: 4609-4619
|
| 15183898 |
Kajiume T et al.:
Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells
Exp. Hematol.
2004
32: 571-578
|
| 23134786 |
Lee SU et al.:
LRF-mediated Dll4 repression in erythroblasts is necessary for hematopoietic stem cell maintenance
Blood
2013
121: 918-929
|
| 15122268 |
Yuan Y et al.:
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C
Nat. Cell Biol.
2004
6: 436-442
|
| 19369945 |
Schwermann J et al.:
MAPKAP kinase MK2 maintains self-renewal capacity of haematopoietic stem cells
EMBO J.
2009
28: 1392-1406
|
| 15457180 |
Hock H et al.:
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
Nature
2004
431: 1002-1007
|
| 21673349 |
Ng AP et al.:
Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice
Blood
2011
118: 2454-2461
|
| 21968513 |
Barroca V et al.:
Impaired functionality and homing of Fancg-deficient hematopoietic stem cells
Hum. Mol. Genet.
2012
21: 121-135
|
| 18397757 |
Min IM et al.:
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
Cell Stem Cell
2008
2: 380-391
|
| 23395001 |
Staber PB et al.:
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells
Mol. Cell
2013
49: 934-946
|
| 22006020 |
Chan WI et al.:
The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells
Mol. Cell. Biol.
2011
31: 5046-5060
|
| 19955420 |
Lieu YK et al.:
Conditional c-myb knockout in adult hematopoietic stem cells leads to loss of self-renewal due to impaired proliferation and accelerated differentiation
Proc. Natl. Acad. Sci. U.S.A.
2009
106
|
| 23360755 |
An N et al.:
Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice: Pim kinase regulates hematopoiesis
J Hematol Oncol
2013
6: 12
|
| 16081537 |
Zhu J et al.:
NF-Ya activates multiple hematopoietic stem cell (HSC) regulatory genes and promotes HSC self-renewal
Proc. Natl. Acad. Sci. U.S.A.
2005
102
|
| 22544701 |
Nishida C et al.:
MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells
Blood
2012
119: 5405-5416
|
| 21768269 |
Pronk CJ et al.:
Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors
J. Exp. Med.
2011
208: 1563-1570
|
| 19664990 |
Renstrom J et al.:
Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells
Cell Stem Cell
2009
5: 157-167
|
| 23149415 |
Ikushima YM et al.:
Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells
Biochem. Biophys. Res. Commun.
2013
430: 20-25
|
| 21885021 |
Matsumoto A et al.:
p57 is required for quiescence and maintenance of adult hematopoietic stem cells
Cell Stem Cell
2011
9: 262-271
|
| 21885020 |
Zou P et al.:
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70
Cell Stem Cell
2011
9: 247-261
|
| 10910909 |
Tsai S et al.:
Mouse Jagged2 is differentially expressed in hematopoietic progenitors and endothelial cells and promotes the survival and proliferation of hematopoietic progenitors by direct cell-to-cell contact
Blood
2000
96: 950-957
|
| 21285514 |
Varnum-Finney B et al.:
Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells
J. Clin. Invest.
2011
121: 1207-1216
|
| 19778523 |
Nakajima H et al.:
Wnt modulators, SFRP-1, and SFRP-2 are expressed in osteoblasts and differentially regulate hematopoietic stem cells
Biochem. Biophys. Res. Commun.
2009
390: 65-70
|
| 17881570 |
Nemeth MJ et al.:
Wnt5a inhibits canonical Wnt signaling in hematopoietic stem cells and enhances repopulation
Proc. Natl. Acad. Sci. U.S.A.
2007
104
|
| 15665828 |
Duncan AW et al.:
Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance
Nat. Immunol.
2005
6: 314-322
|
| 20032500 |
Sun Y et al.:
Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration
Blood
2010
115: 1709-1717
|
| 23434824 |
Tsai JJ et al.:
Nrf2 regulates haematopoietic stem cell function
Nat. Cell Biol.
2013
15: 309-316
|
| 23444405 |
Chan G et al.:
Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis
Blood
2013
121: 3594-3598
|
| 22411870 |
Ross K et al.:
Polycomb group ring finger 1 cooperates with Runx1 in regulating differentiation and self-renewal of hematopoietic cells
Blood
2012
119: 4152-4161
|
| 18354160 |
Ichikawa M et al.:
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis
J. Immunol.
2008
180: 4402-4408
|
| 22117039 |
Ichii M et al.:
The canonical Wnt pathway shapes niches supportive of hematopoietic stem/progenitor cells
Blood
2012
119: 1683-1692
|
| 23434756 |
Greenbaum A et al.:
CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
Nature
2013
495: 227-230
|
| 23434755 |
Ding L et al.:
Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches
Nature
2013
495: 231-235
|
| 23502315 |
Klauke K et al.:
Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation
Nat. Cell Biol.
2013
15: 353-362
|
| 23243277 |
Khurana S et al.:
A novel role of BMP4 in adult hematopoietic stem and progenitor cell homing via Smad independent regulation of integrin-alpha4 expression
Blood
2013
121: 781-790
|
| 19796624 |
Trowbridge JJ et al.:
DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
Cell Stem Cell
2009
5: 442-449
|
| 21873190 |
Ko M et al.:
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
Proc. Natl. Acad. Sci. U.S.A.
2011
108
|
| 18371366 |
Jude CD et al.:
Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors
Cell Stem Cell
2007
1: 324-337
|
| 16293602 |
Kamminga LM et al.:
The Polycomb group gene Ezh2 prevents hematopoietic stem cell exhaustion
Blood
2006
107: 2170-2179
|
| 22042701 |
Mochizuki-Kashio M et al.:
Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells
Blood
2011
118: 6553-6561
|
| 21769133 |
Nguyen AT et al.:
Essential role of DOT1L in maintaining normal adult hematopoiesis
Cell Res.
2011
21: 1370-1373
|
| 16954369 |
Oguro H et al.:
Differential impact of Ink4a and Arf on hematopoietic stem cells and their bone marrow microenvironment in Bmi1-deficient mice
J. Exp. Med.
2006
203: 2247-2253
|
| 18725524 |
Qian Z et al.:
A critical role for Apc in hematopoietic stem and progenitor cell survival
J. Exp. Med.
2008
205: 2163-2175
|
| 23290136 |
Takubo K et al.:
Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells
Cell Stem Cell
2013
12: 49-61
|
| 23502316 |
Ye M et al.:
C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence
Nat. Cell Biol.
2013
15: 385-394
|
| 23716557 |
Guo F et al.:
Mouse gene targeting reveals an essential role of mTOR in hematopoietic stem cell engraftment and hematopoiesis
Haematologica
2013
98: 1353-1358
|
| 22827607 |
Yoon KA et al.:
Differential regulation of CXCL5 by FGF2 in osteoblastic and endothelial niche cells supports hematopoietic stem cell migration
Stem Cells Dev.
2012
21: 3391-3402
|
| 23315170 |
Ikushima YM et al.:
Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
Blood
2013
121: 1995-2007
|
| 23667053 |
Singh RP et al.:
HIF prolyl hydroxylase 2 (PHD2) is a critical regulator of hematopoietic stem cell maintenance during steady-state and stress
Blood
2013
121: 5158-5166
|
| 23670180 |
Stein SJ et al.:
Deletion of the NF-kappaB subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function
Blood
2013
121: 5015-5024
|
| 19850742 |
Lacombe J et al.:
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells
Blood
2010
115: 792-803
|
| 23630229 |
Singh SK et al.:
Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance
J. Exp. Med.
2013
210: 987-1001
|
| 23818291 |
Caselli A et al.:
IGF-1-mediated osteoblastic niche expansion enhances long-term hematopoietic stem cell engraftment after murine bone marrow transplantation
Stem Cells
2013
31: 2193-2204
|
| 23563689 |
Will B et al.:
Satb1 regulates the self-renewal of hematopoietic stem cells by promoting quiescence and repressing differentiation commitment
Nat. Immunol.
2013
14: 437-445
|
| 23122289 |
Hidalgo I et al.:
Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest
Cell Stem Cell
2012
11: 649-662
|
| 22634509 |
Kajiume T et al.:
Regulation of hematopoietic stem cells using protein transduction domain-fused Polycomb
Exp. Hematol.
2012
40: 751-760
|
| 19404261 |
Liu J et al.:
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Nature
2009
459: 387-392
|
| 18039844 |
Cales C et al.:
Inactivation of the polycomb group protein Ring1B unveils an antiproliferative role in hematopoietic cell expansion and cooperation with tumorigenesis associated with Ink4a deletion
Mol. Cell. Biol.
2008
28: 1018-1028
|
| 20445021 |
Majewski IJ et al.:
Opposing roles of polycomb repressive complexes in hematopoietic stem and progenitor cells
Blood
2010
116: 731-739
|
| 16882984 |
Chagraoui J et al.:
E4F1: a novel candidate factor for mediating BMI1 function in primitive hematopoietic cells
Genes Dev.
2006
20: 2110-2120
|
| 23092893 |
Liu Y et al.:
Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus
Sci Signal
2012
5: RA77
|
| 16598206 |
Yilmaz OH et al.:
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
Nature
2006
441: 475-482
|
| 22325351 |
Yu M et al.:
Direct recruitment of polycomb repressive complex 1 to chromatin by core binding transcription factors
Mol. Cell
2012
45: 330-343
|
| 23940708 |
Zhu J et al.:
Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow
PLoS ONE
2013
8
|
| 23974957 |
Frelin C et al.:
GATA-3 regulates the self-renewal of long-term hematopoietic stem cells
Nat. Immunol.
2013
14: 1037-1044
|
| 23375372 |
Brown K et al.:
SIRT3 reverses aging-associated degeneration
Cell Rep
2013
2: 319-327
|
| 24014243 |
Wang T et al.:
The control of hematopoietic stem cell maintenance, self-renewal, and differentiation by Mysm1-mediated epigenetic regulation
Blood
2013
122: 2812-2822
|
| 24012753 |
Poulos MG et al.:
Endothelial jagged-1 is necessary for homeostatic and regenerative hematopoiesis
Cell Rep
2013
4: 1022-1034
|
| 21967974 |
Avagyan S et al.:
Quantitative trait mapping reveals a regulatory axis involving peroxisome proliferator-activated receptors, PRDM16, transforming growth factor-beta2 and FLT3 in hematopoiesis
Blood
2011
118: 6078-6086
|
| 22862945 |
Westerterp M et al.:
Regulation of hematopoietic stem and progenitor cell mobilization by cholesterol efflux pathways
Cell Stem Cell
2012
11: 195-206
|
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