Recurrent fractures

Symptom Information:

Symptom ID: HPO:0002757
Synonyms:
Increased fracture rate [HPO:0002757]
Increased fractures [HPO:0002757]
Multiple fractures [HPO:0002757]
Multiple spontaneous fractures [HPO:0002757]
Varying degree of multiple fractures [HPO:0002757]
Multiple fractures (disorder) [Orphanet:45270]
Fracture, multiple (morphologic abnormality) [Orphanet:45270]
Multiple fractures [Orphanet:45270]
Increased fracture rate [OMIM:Increased fracture rate]
Increased fractures [OMIM:Increased fractures]
Multiple fractures [OMIM:Multiple fractures]
Multiple spontaneous fractures [OMIM:Multiple spontaneous fractures]
Recurrent fractures [OMIM:Recurrent fractures]
Varying degree of multiple fractures [OMIM:Varying degree of multiple fractures]
Mutiple fractures/bone fragility [Orphanet:45270]
Multiple fractures [MedDRA:10028200]
Broken bones [MedDRA:10028200]
Clo fos or face &
oth bones, with intcran inj of oth &
unspec nature, with prol loc and rtrn to pecl [MedDRA:10028200]
Clo fos or face &
oth bones, with intcran inj of oth &
unspec nature, with prol loc,w/o rtrn to pecl [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with concus, unspec [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with loc of unspec dura [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with no loc [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with prol loc and rtrn to pecl [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Clo fos or face with oth bones with subarac, sub/extradural hem, with state of cons unspec [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with brief loc [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with concussion, unspec [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with loc of unspec dura [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with mod loc [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with no loc [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with prol loc and return [MedDRA:10028200]
clo fos or face with oth bones, with intcran inj of oth and unspec nature, with prol loc, w/o return [MedDRA:10028200]
Clo fos or face with oth bones, with intcran inj of oth and unspec nature, with state of cons unspec [MedDRA:10028200]
Clo fos or face with oth bones, with oth and unspec intcran hem, with concus, unspec [MedDRA:10028200]
Clo fos or face with oth bones, with oth and unspec intcran hem, with loc of unspec duration [MedDRA:10028200]
Clo fos or face with oth bones, with oth and unspec intcran hem, with prol loc and rtrn to pecl [MedDRA:10028200]
Clo fos or face with oth bones, with oth and unspec intcran hem, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Clo fos or face with oth bones, with oth and unspec intcran hem, with state of cons unspec [MedDRA:10028200]
Closed fos of face with oth bones, w/o ment of intcran inj, with concussion, unspec [MedDRA:10028200]
Closed fos of face with oth bones, w/o ment of intcran inj, with loc of unspec duration [MedDRA:10028200]
Closed fos of face with oth bones, w/o ment of intcran inj, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Closed fos or face with oth bones with subarac, sub/extradural hem [MedDRA:10028200]
Closed fos or face with oth bones with subarac, sub/extradural hem, with brief loc [MedDRA:10028200]
Closed fos or face with oth bones with subarac, sub/extradural hem, with moderate loc [MedDRA:10028200]
Closed fos or face with oth bones, w/o ment of intcran inj, with brief loc [MedDRA:10028200]
Closed fos or face with oth bones, w/o ment of intcran inj, with moderate loc [MedDRA:10028200]
Closed fos or face with oth bones, w/o ment of intcran inj, with no loc [MedDRA:10028200]
Closed fos or face with oth bones, w/o ment of intcran inj, with state of consciousness unspec [MedDRA:10028200]
Closed fos or face with oth bones, w/o ment or intcran inj, with prolonged loc and return to pecl [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with brief loc [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with concussion, unspec [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with loc of unspec duration [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with moderate loc [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with no loc [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with prol loc and rtrn to pecl [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Closed fos or face with oth bones, with cerebral lacer and contu, with state of cons unspec [MedDRA:10028200]
Closed fos or face with oth bones, with intcran inj of oth and unspec nature [MedDRA:10028200]
Closed fos or face with oth bones, with oth and unspec intcran hem [MedDRA:10028200]
Closed fos or face with oth bones, with oth and unspec intcran hem, with brief loc [MedDRA:10028200]
Closed fos or face with oth bones, with oth and unspec intcran hem, with moderate loc [MedDRA:10028200]
Closed fos or face with oth bones, with oth and unspec intcran hem, with no loc [MedDRA:10028200]
Closed fractures involving skull or face with other bones, with cerebral laceration and contusion [MedDRA:10028200]
Closed fractures involving skull or face with other bones, without mention of intracranial injury [MedDRA:10028200]
Fracture multiple [MedDRA:10028200]
Multiple closed fractures involving both upper limbs, and upper limb with rib(s) and sternum [MedDRA:10028200]
Multiple fracts involv both lwr limbs, lwr with upr limb, and lwr limb with rib and sternum, closed [MedDRA:10028200]
Multiple fracts involv both lwr limbs, lwr with upr limb, and lwr limb with rib and sternum, open [MedDRA:10028200]
Multiple fractures involving both lwr limbs, lwr with upr limb, and lwr limb with rib and sternum [MedDRA:10028200]
Multiple fractures involving both upper limbs, and upper limb with rib(s) and sternum [MedDRA:10028200]
Multiple fractures involving both upper limbs, and upper limb with ribs and sternum [MedDRA:10028200]
Multiple fractures involving skull or face with other bones [MedDRA:10028200]
Multiple open fractures involving both upper limbs, and upper limb with rib(s) and sternum [MedDRA:10028200]
Open fos or face &
oth bones, with intcran inj of oth and unspec nature, prol loc, w/o rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem , with state of cons unspec [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with brief loc [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with concussion, unspec [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with loc of unspec duration [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with moderate loc [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with no loc [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with prol loc and rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones with subarac, sub/extradural hem, with state of consciousness unspec [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with brief loc [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with concussion, unspec [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with loc of unspec duration [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with moderate loc [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with no loc [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with prolonged loc and return to pecl [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with prolonged loc, w/o return to pecl [MedDRA:10028200]
Open fos or face with oth bones, w/o ment of intcran inj, with state of consciousness unspec [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with brief loc [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with concussion, unspec [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with loc of unspec duration [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with moderate loc [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with no loc [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with prol loc and rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones, with cerebral lacer and contu, with state of cons unspec [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, prol loc, w/o rtrn to pe [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, state of cons unspec [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with brief loc [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with concus, unspec [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with loc of unspec dura [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with moderate loc [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with no loc [MedDRA:10028200]
Open fos or face with oth bones, with intcran inj of oth and unspec nature, with prol loc and return [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with brief loc [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with concussion, unspec [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with loc of unspec duration [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with moderate loc [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with no loc [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with prol loc and rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with prol loc, w/o rtrn to pecl [MedDRA:10028200]
Open fos or face with oth bones, with oth and unspec intcran hem, with state of cons unspec [MedDRA:10028200]
Open fractures involving skull or face with other bones, with cerebral laceration and contusion [MedDRA:10028200]
Open fractures involving skull or face with other bones, without mention of intracranial injury [MedDRA:10028200]
Other ill-defined fractures of lower limb [MedDRA:10028200]
Other, multiple and ill-defined fractures of lower limb, closed [MedDRA:10028200]
Other, multiple and ill-defined fractures of lower limb, open [MedDRA:10028200]
Other, multiple, and ill-defined fractures of lower limb [MedDRA:10028200]
Increased fractures (in some patients) [OMIM:Increased fractures (in some patients)]
Recurrent fractures (hypophosphatasia only) [OMIM:Recurrent fractures (hypophosphatasia only)]
Quality:
Cross references:
Orphanet:45270 "Mutiple fractures/bone fragility" [Orphanet:45270]
OMIM: "Increased fracture rate" [OMIM:Increased fracture rate]
OMIM: "Increased fractures" [OMIM:Increased fractures]
OMIM: "Multiple fractures" [OMIM:Multiple fractures]
OMIM: "Multiple spontaneous fractures" [OMIM:Multiple spontaneous fractures]
OMIM: "Recurrent fractures" [OMIM:Recurrent fractures]
OMIM: "Varying degree of multiple fractures" [OMIM:Varying degree of multiple fractures]
OMIM: "Increased fractures (in some patients)" [OMIM:Increased fractures (in some patients)]
OMIM: "Recurrent fractures (hypophosphatasia only)" [OMIM:Recurrent fractures (hypophosphatasia only)]
UMLS:C0016655 "Multiple fractures" [Orphanet:45270]
Is a (Direct Parents):
MedDRA Fractures NEC
HPO         Increased susceptibility to fractures
Orphanet Abnormality of the skeletal system
Orphanet Increased susceptibility to fractures
Is a (Whole tree): HPO:
All(HPO:0000001)
    Phenotypic abnormality(HPO:0000118)
       Abnormality of the skeletal system(HPO:0000924)
          Abnormality of skeletal physiology(HPO:0011843)
             Increased susceptibility to fractures(HPO:0002659)
                Recurrent fractures(HPO:0002757)
MedDRA:
Musculoskeletal and connective tissue disorders(MedDRA:10028395)
    Fractures(MedDRA:10017322)
       Fractures NEC(MedDRA:10072986)
          Recurrent fractures(HPO:0002757)
Database Frequency: 47 / 7739
Resource:

All diseases associated with this symptom:

Adult hypophosphatasia (Orphanet:247676)
Albers-Schönberg osteopetrosis (Orphanet:53)
Autosomal dominant hyper-IgE syndrome (Orphanet:2314)
BRITTLE CORNEA SYNDROME 2 (OMIM:614170)
Berardinelli-Seip congenital lipodystrophy (Orphanet:528)
Buschke-Ollendorff syndrome (Orphanet:1306)
Calvarial doughnut lesions - bone fragility (Orphanet:85192)
Cole-Carpenter syndrome (Orphanet:2050)
Cushing disease (Orphanet:96253)
Cushing syndrome (Orphanet:553)
Dent disease type 1 (Orphanet:93622)
Familial exudative vitreoretinopathy (Orphanet:891)
GCS1-CDG (Orphanet:79330)
HYPOPHOSPHATEMIC RICKETS, X-LINKED RECESSIVE (OMIM:300554)
Hereditary hypophosphatemic rickets with hypercalciuria (Orphanet:157215)
Hypocalcemic vitamin D-dependent rickets (Orphanet:289157)
Hypocalcemic vitamin D-resistant rickets (Orphanet:93160)
Intellectual deficit, X-linked, Snyder type (Orphanet:3063)
Linear nevus sebaceus syndrome (Orphanet:2612)
MACROEPIPHYSEAL DYSPLASIA WITH OSTEOPOROSIS, WRINKLED SKIN, AND AGEDAPPEARANCE (OMIM:248010)
Menkes disease (Orphanet:565)
Mohr-Tranebjaerg syndrome (Orphanet:52368)
NEUROLOGIC DISEASE, INFANTILE MULTISYSTEM, WITH OSSEOUS FRAGILITY (OMIM:256720)
Neonatal severe primary hyperparathyroidism (Orphanet:417)
OSTEOGENESIS IMPERFECTA, TYPE I (OMIM:166200)
OSTEOGENESIS IMPERFECTA, TYPE IV (OMIM:166220)
OSTEOGENESIS IMPERFECTA, TYPE IX (OMIM:259440)
OSTEOGENESIS IMPERFECTA, TYPE V (OMIM:610967)
OSTEOGENESIS IMPERFECTA, TYPE VII (OMIM:610682)
OSTEOGENESIS IMPERFECTA, TYPE VIII (OMIM:610915)
OSTEOGENESIS IMPERFECTA, TYPE XIV (OMIM:615066)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 4 (OMIM:611490)
OSTEOPETROSIS, AUTOSOMAL RECESSIVE 2 (OMIM:259710)
OSTEOSCLEROSIS WITH ICHTHYOSIS AND FRACTURES (OMIM:166740)
Odontohypophosphatasia (Orphanet:247685)
Osteogenesis imperfecta type 1 (Orphanet:216796)
Osteogenesis imperfecta type 2 (Orphanet:216804)
Osteogenesis imperfecta type 3 (Orphanet:216812)
Osteogenesis imperfecta type 4 (Orphanet:216820)
Osteogenesis imperfecta type 5 (Orphanet:216828)
Perinatal lethal hypophosphatasia (Orphanet:247623)
Primary Fanconi syndrome (Orphanet:3337)
Retinopathy of prematurity (Orphanet:90050)
VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A (OMIM:264700)
VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1B (OMIM:600081)
VITAMIN D-DEPENDENT RICKETS, TYPE 2A (OMIM:277440)
Wolcott-Rallison syndrome (Orphanet:1667)