Symptom Information: Sort according to HPO 

1
 (HPO:0000964) Eczema Occasional [Orphanet] 81 / 7739
2
 (HPO:0002664) Neoplasm Occasional [Orphanet] 111 / 7739
3
 (HPO:0010783) Erythema Very frequent [Orphanet] 138 / 7739
4
 (HPO:0000989) Pruritus Frequent [Orphanet] 111 / 7739
5
 (HPO:0008064) Ichthyosis Occasional [Orphanet] 108 / 7739
6
 (HPO:0200039) Pustule Occasional [Orphanet] 20 / 7739
7
 (HPO:0001072) Thickened skin Frequent [Orphanet] 87 / 7739
8
 (HPO:0001805) Thick nail Frequent [Orphanet] 96 / 7739
9
 (HPO:0000982) Palmoplantar keratoderma 40 / 7739
10
 (HPO:0007400) Irregular hyperpigmentation Very frequent [Orphanet] 72 / 7739
11
 (HPO:0001597) Abnormality of the nail Frequent [Orphanet] 115 / 7739
12
 (HPO:0000163) Abnormality of the oral cavity Occasional [Orphanet] 37 / 7739
13
 (HPO:0008392) Subungual hyperkeratosis 6 / 7739
14
 (HPO:0100725) Lichenification Occasional [Orphanet] 14 / 7739
15
 (OMIM) Scaly scalp (in some patients) 1 / 7739
16
 (OMIM) Ectropion, bilateral (in some patients) 1 / 7739
17
 (OMIM) Papules, keratotic follicular 1 / 7739
18
 (OMIM) Plaques, erythematous, covered with fine powdery scales 1 / 7739
19
 (OMIM) Islands of uninvolved skin 1 / 7739
20
 (OMIM) Hyperkeratosis, mild to moderate 1 / 7739
21
 (OMIM) Focal parakeratosis 1 / 7739
22
 (OMIM) Focal orthokeratosis 1 / 7739
23
 (OMIM) Focal hypergranulosis 1 / 7739
24
 (OMIM) Mild acanthosis, with broad and blunted rete ridges 1 / 7739
25
 (OMIM) Focal keratotic plugging 1 / 7739
26
 (OMIM) Mononuclear cell infiltrate in the dermis 1 / 7739
27
 (OMIM) Discoloration, yellow-brown 1 / 7739
28
 (OMIM) Nail plate thickening 1 / 7739
29
 (OMIM) Splinter hemorrhages 2 / 7739
30
 (OMIM) Transverse ridging 2 / 7739
31
 (HPO:0030350) Erythematous papule Very frequent [Orphanet] 123 / 7739
32
 (HPO:0000962) Hyperkeratosis Very frequent [Orphanet] 216 / 7739
33
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739