1
|
(HPO:0002206)
|
Pulmonary fibrosis |
Very frequent [IBIS]
|
|
10673212
|
IBIS
|
51 / 7739
|
2
|
(OMIM)
|
Pulmonary fibrosis with fibroblast foci on histology |
Very frequent [IBIS]
|
|
21642472; 19287097
|
IBIS
|
3 / 7739
|
3
|
(HPO:0006530)
|
Interstitial pulmonary disease |
Very frequent [IBIS]
|
|
24424167
|
IBIS
|
26 / 7739
|
4
|
(MedDRA:10021240)
|
Idiopathic pulmonary fibrosis |
Very frequent [IBIS]
|
|
24424167
|
IBIS
|
1 / 7739
|
5
|
(MedDRA:10037833)
|
Rales |
Frequent [IBIS]
|
85.6% (n=132)
|
23432171
|
IBIS
|
4 / 7739
|
6
|
(HPO:0002094)
|
Dyspnea |
Frequent [IBIS]
|
68.2% (n=132)
|
23432171
|
IBIS
|
132 / 7739
|
7
|
(HPO:0012735)
|
Cough |
Frequent [IBIS]
|
60.6% (n=132)
|
23432171; 25984423
|
IBIS
|
24 / 7739
|
8
|
(HPO:0002111)
|
Restrictive deficit on pulmonary function testing |
Frequent [IBIS]
|
58.3% (n=132)
|
23432171
|
IBIS
|
25 / 7739
|
9
|
(HPO:0100759)
|
Clubbing of fingers |
50 % [HPO]
Frequent [IBIS]
|
53.3% (n=132)
|
23432171
|
IBIS
|
40 / 7739
|
10
|
(HPO:0002097)
|
Emphysema |
Frequent [IBIS]
|
42% (n=210)
|
24824247
|
IBIS
|
40 / 7739
|
11
|
(OMIM)
|
Honeycomb fibrosis, varying in age and location |
Frequent [IBIS]
|
|
10673212
|
IBIS
|
6 / 7739
|
12
|
(HPO:0001217)
|
Clubbing |
Frequent [IBIS]
|
|
25984423
|
IBIS
|
39 / 7739
|
13
|
(HPO:0002795)
|
Functional respiratory abnormality |
Frequent [IBIS]
|
|
23432171
|
IBIS
|
13 / 7739
|
14
|
(HPO:0011991)
|
Abnormal neutrophil cell number |
Frequent [IBIS]
|
|
10673212
|
IBIS
|
3 / 7739
|
15
|
(HPO:0002092)
|
Pulmonary hypertension |
Occasional [IBIS]
|
29% (n=210)
|
24824247
|
IBIS
|
109 / 7739
|
16
|
(MedDRA:10067182)
|
Bronchial wall thickening |
Occasional [IBIS]
|
18.8 % (n=16)
|
24998369
|
IBIS
|
5 / 7739
|
17
|
(HPO:0100749)
|
Chest pain |
Occasional [IBIS]
|
8.3% (n=132)
|
23432171
|
IBIS
|
92 / 7739
|
18
|
(HPO:0012378)
|
Fatigue |
Occasional [IBIS]
|
7.6% (n=132)
|
23432171
|
IBIS
|
50 / 7739
|
19
|
(HPO:0000961)
|
Cyanosis |
Occasional [IBIS]
|
6.8% (n=132)
|
23432171
|
IBIS
|
60 / 7739
|
20
|
(HPO:0001945)
|
Fever |
Occasional [IBIS]
|
4.5% (n=132)
|
23432171
|
IBIS
|
218 / 7739
|
21
|
(HPO:0003493)
|
Antinuclear antibody positivity |
Occasional [IBIS]
|
|
10673212
|
IBIS
|
15 / 7739
|
22
|
(HPO:0002923)
|
Rheumatoid factor positive |
Occasional [IBIS]
|
|
10673212
|
IBIS
|
5 / 7739
|
23
|
(HPO:0001394)
|
Cirrhosis |
|
|
22853774
|
IBIS
|
102 / 7739
|
24
|
(HPO:0002875)
|
Exertional dyspnea |
|
|
16809633
|
IBIS
|
29 / 7739
|
25
|
(HPO:0010702)
|
Increased antibody level in blood |
|
|
14338292
|
IBIS
|
29 / 7739
|
26
|
(HPO:0100760)
|
Clubbing of toes |
|
|
23133780
|
IBIS
|
24 / 7739
|
27
|
(HPO:0001648)
|
Cor pulmonale |
|
|
18366757
|
IBIS
|
16 / 7739
|
28
|
(MedDRA:10070955)
|
Right ventricular heave |
|
|
10673212
|
IBIS
|
1 / 7739
|
29
|
(HPO:0012398)
|
Peripheral edema |
|
|
10673212
|
IBIS
|
12 / 7739
|
30
|
(HPO:0001824)
|
Weight loss |
|
|
10673212
|
IBIS
|
42 / 7739
|
31
|
(HPO:0012418)
|
Hypoxemia |
|
|
10673212
|
IBIS
|
18 / 7739
|
32
|
(HPO:0002207)
|
Diffuse reticular or finely nodular infiltrations |
|
|
10673212
|
IBIS
|
11 / 7739
|
33
|
(HPO:0002093)
|
Respiratory insufficiency |
|
|
10673212
|
IBIS
|
410 / 7739
|
34
|
(HPO:0002110)
|
Bronchiectasis |
|
|
10673212
|
IBIS
|
73 / 7739
|
35
|
(HPO:0002792)
|
Reduced vital capacity |
|
|
10673212
|
IBIS
|
17 / 7739
|
36
|
(HPO:0002789)
|
Tachypnea |
|
|
10673212
|
IBIS
|
48 / 7739
|
37
|
(HPO:0002360)
|
Sleep disturbance |
|
|
10673212
|
IBIS
|
113 / 7739
|
38
|
(HPO:0002020)
|
Gastroesophageal reflux |
|
|
21471066
|
IBIS
|
101 / 7739
|
39
|
(HPO:0010535)
|
Sleep apnea |
|
|
21471066
|
IBIS
|
24 / 7739
|
40
|
(HPO:0001513)
|
Obesity |
|
|
21471066
|
IBIS
|
172 / 7739
|
41
|
(MedDRA:10065906)
|
Carbon monoxide diffusing capacity decreased |
|
|
23937857
|
IBIS
|
8 / 7739
|
42
|
(OMIM)
|
Reduced diffusion capacity |
|
|
23937857
|
IBIS
|
8 / 7739
|
43
|
(HPO:0012415)
|
Abnormal blood gas level |
|
|
23937857
|
IBIS
|
9 / 7739
|
44
|
(OMIM)
|
Radiograph shows ground glass appearance |
|
|
25672832
|
IBIS
|
7 / 7739
|
45
|
(MedDRA:10017507)
|
Functional residual capacity decreased |
|
|
24424167
|
IBIS
|
1 / 7739
|
46
|
(OMIM)
|
Reduced forced vital capacity |
|
|
25984423
|
IBIS
|
3 / 7739
|
47
|
(HPO:0000988)
|
Skin rash |
|
|
24504062
|
IBIS
|
98 / 7739
|
48
|
(MedDRA:10062759)
|
Congenital dyskeratosis |
|
|
24504062
|
IBIS
|
1 / 7739
|
49
|
(MedDRA:10001889)
|
Alveolitis |
|
|
10936140
|
IBIS
|
3 / 7739
|
50
|
(HPO:0002109)
|
Abnormality of the bronchi |
|
|
10936140
|
IBIS
|
6 / 7739
|
51
|
(HPO:0002113)
|
Pulmonary infiltrates |
|
|
10673212
|
IBIS
|
36 / 7739
|
52
|
(MedDRA:10062049)
|
Lymphocytic infiltration |
|
|
23576879
|
IBIS
|
9 / 7739
|
53
|
(MedDRA:10064780)
|
Breath sounds abnormal |
|
|
23432171
|
IBIS
|
3 / 7739
|
54
|
(MedDRA:10016987)
|
Forced expiratory volume decreased |
|
|
23776595
|
IBIS
|
2 / 7739
|