1
|
(HPO:0009830)
|
Peripheral neuropathy |
Very frequent [Orphanet]
Frequent [IBIS]
|
51.4% (n=383)
|
23044708
|
IBIS
|
206 / 7739
|
2
|
(HPO:0001824)
|
Weight loss |
Frequent [IBIS]
|
49.3% (n=383)
|
23044708
|
IBIS
|
42 / 7739
|
3
|
(HPO:0000246)
|
Sinusitis |
Very frequent [Orphanet]
Frequent [IBIS]
|
41.8% (n=383)
|
23044708
|
IBIS
|
73 / 7739
|
4
|
(HPO:0002113)
|
Pulmonary infiltrates |
Very frequent [Orphanet]
Frequent [IBIS]
|
38.6% (n=383)
|
23044708
|
IBIS
|
36 / 7739
|
5
|
(HPO:0000979)
|
Purpura |
Occasional [IBIS]
|
22.5% (n=383)
|
23044708
|
IBIS
|
27 / 7739
|
6
|
(HPO:0012384)
|
Rhinitis |
Occasional [IBIS]
|
17% (n=383)
|
23044708
|
IBIS
|
18 / 7739
|
7
|
(HPO:0001638)
|
Cardiomyopathy |
Occasional [Orphanet]
Occasional [IBIS]
|
16.4% (n=383)
|
23044708
|
IBIS
|
192 / 7739
|
8
|
(HPO:0001701)
|
Pericarditis |
Occasional [IBIS]
|
15.1% (n=383)
|
23044708
|
IBIS
|
13 / 7739
|
9
|
(HPO:0000093)
|
Proteinuria |
Occasional [Orphanet]
Occasional [IBIS]
|
12.8% (n=383)
|
25971154
|
IBIS
|
169 / 7739
|
10
|
(HPO:0001482)
|
Subcutaneous nodule |
Occasional [IBIS]
|
9.7% (n=383)
|
23044708
|
IBIS
|
17 / 7739
|
11
|
(HPO:0002202)
|
Pleural effusion |
Occasional [IBIS]
|
|
26963455
|
IBIS
|
22 / 7739
|
12
|
(HPO:0100749)
|
Chest pain |
Rare [IBIS]
|
7.3 % (n=383)
|
23044708
|
IBIS
|
92 / 7739
|
13
|
(HPO:0006535)
|
Recurrent intrapulmonary hemorrhage |
Rare [IBIS]
|
4.2% (n=383)
|
23044708
|
IBIS
|
3 / 7739
|
14
|
(HPO:0000965)
|
Cutis marmorata |
Occasional [Orphanet]
Rare [IBIS]
|
3.9% (n=383)
|
23044708
|
IBIS
|
46 / 7739
|
15
|
(HPO:0000083)
|
Renal insufficiency |
Occasional [Orphanet]
|
|
25971154
|
IBIS
|
232 / 7739
|
16
|
(HPO:0000790)
|
Hematuria |
Frequent [Orphanet]
|
|
25971154
|
IBIS
|
106 / 7739
|
17
|
(HPO:0000822)
|
Hypertension |
Frequent [Orphanet]
|
|
26702692
|
IBIS
|
224 / 7739
|
18
|
(HPO:0000988)
|
Skin rash |
Frequent [Orphanet]
|
|
23044708
|
IBIS
|
98 / 7739
|
19
|
(HPO:0001025)
|
Urticaria |
Very frequent [Orphanet]
|
|
25500434
|
IBIS
|
73 / 7739
|
20
|
(HPO:0001288)
|
Gait disturbance |
Frequent [Orphanet]
|
|
22525641
|
IBIS
|
318 / 7739
|
21
|
(HPO:0005059)
|
Arthralgia/arthritis |
Frequent [Orphanet]
|
|
25500434
|
IBIS
|
141 / 7739
|
22
|
(HPO:0001635)
|
Congestive heart failure |
Very frequent [Orphanet]
|
|
26418389
|
IBIS
|
232 / 7739
|
23
|
(HPO:0001677)
|
Coronary artery disease |
Occasional [Orphanet]
|
|
26702692
|
IBIS
|
58 / 7739
|
24
|
(HPO:0001697)
|
Abnormality of the pericardium |
Frequent [Orphanet]
|
|
23044708
|
IBIS
|
52 / 7739
|
25
|
(HPO:0001879)
|
Abnormality of eosinophils |
Very frequent [Orphanet]
|
|
25971154
|
IBIS
|
20 / 7739
|
26
|
(HPO:0001933)
|
Subcutaneous hemorrhage |
Very frequent [Orphanet]
|
|
25971154
|
IBIS
|
50 / 7739
|
27
|
(HPO:0002017)
|
Nausea and vomiting |
Frequent [Orphanet]
|
|
25971154
|
IBIS
|
134 / 7739
|
28
|
(HPO:0002027)
|
Abdominal pain |
Frequent [Orphanet]
|
|
25971154
|
IBIS
|
184 / 7739
|
29
|
(HPO:0002093)
|
Respiratory insufficiency |
Occasional [Orphanet]
|
|
26759439
|
IBIS
|
410 / 7739
|
30
|
(HPO:0002099)
|
Asthma |
Very frequent [Orphanet]
|
|
25971154
|
IBIS
|
62 / 7739
|
31
|
(HPO:0002103)
|
Abnormality of the pleura |
Frequent [Orphanet]
|
|
16612766
|
IBIS
|
58 / 7739
|
32
|
(HPO:0002105)
|
Hemoptysis |
Occasional [Orphanet]
|
|
22640651
|
IBIS
|
30 / 7739
|
33
|
(HPO:0002960)
|
Autoimmunity |
Very frequent [Orphanet]
|
|
23149338
|
IBIS
|
78 / 7739
|
34
|
(HPO:0003326)
|
Myalgia |
Occasional [Orphanet]
|
|
25971154
|
IBIS
|
143 / 7739
|
35
|
(HPO:0004306)
|
Abnormality of the endocardium |
Occasional [Orphanet]
|
|
19507576
|
IBIS
|
24 / 7739
|
36
|
(HPO:0004374)
|
Hemiplegia/hemiparesis |
Occasional [Orphanet]
|
|
25473575
|
IBIS
|
158 / 7739
|
37
|
(HPO:0004936)
|
Venous thrombosis |
Frequent [Orphanet]
|
|
22272911
|
IBIS
|
41 / 7739
|
38
|
(HPO:0005214)
|
Intestinal obstruction |
Occasional [Orphanet]
|
|
25473392
|
IBIS
|
35 / 7739
|
39
|
(HPO:0006824)
|
Cranial nerve paralysis |
Occasional [Orphanet]
|
|
23044708
|
IBIS
|
81 / 7739
|
40
|
(HPO:0100582)
|
Nasal polyposis |
Occasional [Orphanet]
|
|
25500434
|
IBIS
|
14 / 7739
|
41
|
(HPO:0100614)
|
Myositis |
Occasional [Orphanet]
|
|
25414144
|
IBIS
|
21 / 7739
|
42
|
(HPO:0100820)
|
Glomerulopathy |
Occasional [Orphanet]
|
|
25500434
|
IBIS
|
46 / 7739
|
43
|
(HPO:0001970)
|
Tubulointerstitial nephritis |
Frequent [Orphanet]
|
|
25500434
|
IBIS
|
27 / 7739
|
44
|
(HPO:0011227)
|
Elevated C-reactive protein level |
Very frequent [Orphanet]
|
|
24574837
|
IBIS
|
55 / 7739
|
45
|
(HPO:0001637)
|
Abnormality of the myocardium |
Occasional [Orphanet]
|
|
26702692
|
IBIS
|
76 / 7739
|
46
|
(HPO:0002140)
|
Ischemic stroke |
Occasional [Orphanet]
|
|
26702692
|
IBIS
|
70 / 7739
|
47
|
(HPO:0012089)
|
Arteritis |
Very frequent [Orphanet]
|
|
20949297
|
IBIS
|
40 / 7739
|
48
|
(HPO:0002015)
|
Dysphagia |
Frequent [Orphanet]
|
|
26161355
|
IBIS
|
301 / 7739
|
49
|
(HPO:0001945)
|
Fever |
Occasional [Orphanet]
|
|
25500434
|
IBIS
|
218 / 7739
|
50
|
(HPO:0001324)
|
Muscle weakness |
Frequent [Orphanet]
|
|
25971154
|
IBIS
|
859 / 7739
|
51
|
(HPO:0002242)
|
Abnormality of the intestine |
Occasional [Orphanet]
|
|
21977190
|
IBIS
|
42 / 7739
|
52
|
(HPO:0012638)
|
Abnormality of nervous system physiology |
Very frequent [Orphanet]
|
|
23044708
|
IBIS
|
12 / 7739
|
53
|
(HPO:0002088)
|
Abnormality of lung morphology |
Occasional [Orphanet]
|
|
16612766
|
IBIS
|
11 / 7739
|
54
|
(HPO:0002577)
|
Abnormality of the stomach |
Occasional [Orphanet]
|
|
25473392
|
IBIS
|
84 / 7739
|
55
|
(HPO:0030350)
|
Erythematous papule |
Occasional [Orphanet]
|
|
20949297
|
IBIS
|
123 / 7739
|
56
|
([DEL]MedDRA:10011224)
|
Cough |
Occasional [Orphanet]
|
|
25121017
|
IBIS
|
70 / 7739
|
57
|
(HPO:0001880)
|
Eosinophilia |
|
|
25971154
|
IBIS
|
35 / 7739
|
58
|
(HPO:0011109)
|
Chronic sinusitis |
|
|
25500434
|
IBIS
|
17 / 7739
|
59
|
(HPO:0002248)
|
Hematemesis |
|
|
25971154
|
IBIS
|
12 / 7739
|
60
|
(HPO:0000099)
|
Glomerulonephritis |
|
|
25971154
|
IBIS
|
13 / 7739
|
61
|
(HPO:0003193)
|
Allergic rhinitis |
|
|
25500434
|
IBIS
|
6 / 7739
|
62
|
(HPO:0000388)
|
Otitis media |
|
|
25500434
|
IBIS
|
28 / 7739
|
63
|
(HPO:0000407)
|
Sensorineural hearing impairment |
|
|
25500434
|
IBIS
|
524 / 7739
|
64
|
(HPO:0010628)
|
Facial palsy |
|
|
25500434
|
IBIS
|
146 / 7739
|
65
|
(HPO:0002110)
|
Bronchiectasis |
|
|
25500434
|
IBIS
|
73 / 7739
|
66
|
(HPO:0011675)
|
Arrhythmia |
|
|
25500434
|
IBIS
|
226 / 7739
|
67
|
(HPO:0011944)
|
Small vessel vasculitis |
|
|
25500434
|
IBIS
|
3 / 7739
|
68
|
(HPO:0003401)
|
Paresthesia |
|
|
26702692
|
IBIS
|
42 / 7739
|
69
|
(HPO:0001644)
|
Dilated cardiomyopathy |
|
|
25883756
|
IBIS
|
141 / 7739
|
70
|
(HPO:0012719)
|
Functional abnormality of the gastrointestinal tract |
|
|
25500434
|
IBIS
|
17 / 7739
|
71
|
(HPO:0002014)
|
Diarrhea |
|
|
21977190
|
IBIS
|
225 / 7739
|