|
1
|
(HPO:0000726)
|
Dementia |
|
|
|
|
131 / 7739
|
|
2
|
(HPO:0002063)
|
Rigidity |
|
|
|
|
92 / 7739
|
|
3
|
(HPO:0002067)
|
Bradykinesia |
|
|
|
|
62 / 7739
|
|
4
|
(HPO:0002172)
|
Postural instability |
|
|
|
|
22 / 7739
|
|
5
|
(HPO:0002322)
|
Resting tremor |
|
|
|
|
14 / 7739
|
|
6
|
(HPO:0002548)
|
Parkinsonism with favorable response to dopaminergic medication |
|
|
|
|
13 / 7739
|
|
7
|
(HPO:0004409)
|
Hyposmia |
|
|
|
|
16 / 7739
|
|
8
|
(HPO:0011960)
|
Substantia nigra gliosis |
|
|
|
|
4 / 7739
|
|
9
|
(HPO:0001300)
|
Parkinsonism |
|
|
|
|
75 / 7739
|
|
10
|
(HPO:0001268)
|
Mental deterioration |
|
|
|
|
88 / 7739
|
|
11
|
(OMIM)
|
Neuronal loss in the substantia nigra |
|
|
|
|
2 / 7739
|
|
12
|
(OMIM)
|
Gliosis in the substantia nigra |
|
|
|
|
1 / 7739
|
|
13
|
(OMIM)
|
Pigmentary loss in the substantia nigra |
|
|
|
|
1 / 7739
|
|
14
|
(HPO:0100315)
|
Lewy bodies |
|
|
|
|
5 / 7739
|
|
15
|
(OMIM)
|
Neurofibrillary MAPT (tau)-positive tangles |
|
|
|
|
1 / 7739
|
|
16
|
(OMIM)
|
Secondary motor complications develop in 50% of those on levodopa therapy |
|
|
|
|
1 / 7739
|
|
17
|
(HPO:0000006)
|
Autosomal dominant inheritance |
|
|
|
|
2518 / 7739
|
|
18
|
(HPO:0003677)
|
Slow progression |
|
|
|
|
134 / 7739
|
|
19
|
(HPO:0003829)
|
Incomplete penetrance |
|
|
|
|
85 / 7739
|