|
1
|
(HPO:0000160)
|
Narrow mouth |
|
|
|
|
188 / 7739
|
|
2
|
(HPO:0000162)
|
Glossoptosis |
|
|
|
|
26 / 7739
|
|
3
|
(HPO:0000175)
|
Cleft palate |
|
|
|
|
349 / 7739
|
|
4
|
(HPO:0000256)
|
Macrocephaly |
|
|
|
|
298 / 7739
|
|
5
|
(HPO:0001355)
|
Megalencephaly |
|
|
|
|
39 / 7739
|
|
6
|
(HPO:0004482)
|
Relative macrocephaly |
|
|
|
|
44 / 7739
|
|
7
|
(HPO:0000311)
|
Round face |
|
|
|
|
104 / 7739
|
|
8
|
(HPO:0000347)
|
Micrognathia |
|
|
|
|
426 / 7739
|
|
9
|
(HPO:0000358)
|
Posteriorly rotated ears |
|
|
|
|
163 / 7739
|
|
10
|
(HPO:0000369)
|
Low-set ears |
|
|
|
|
372 / 7739
|
|
11
|
(HPO:0000678)
|
Dental crowding |
|
|
|
|
65 / 7739
|
|
12
|
(HPO:0000689)
|
Dental malocclusion |
|
|
|
|
114 / 7739
|
|
13
|
(HPO:0002104)
|
Apnea |
|
|
|
|
106 / 7739
|
|
14
|
(HPO:0004453)
|
Overfolding of the superior helices |
|
|
|
|
5 / 7739
|
|
15
|
(HPO:0007627)
|
Mandibular condyle aplasia |
|
|
|
|
3 / 7739
|
|
16
|
(HPO:0007628)
|
Mandibular condyle hypoplasia |
|
|
|
|
4 / 7739
|
|
17
|
(HPO:0008537)
|
Cleft at the superior portion of the pinna |
|
|
|
|
3 / 7739
|
|
18
|
(HPO:0008559)
|
Hypoplastic superior helix |
|
|
|
|
6 / 7739
|
|
19
|
(HPO:0009088)
|
Speech articulation difficulties |
|
|
|
|
4 / 7739
|
|
20
|
(OMIM)
|
Prominent cheeks |
|
|
|
|
4 / 7739
|
|
21
|
(HPO:0000377)
|
Abnormality of the pinna |
|
|
|
|
111 / 7739
|
|
22
|
(OMIM)
|
Auricular clefts |
|
|
|
|
2 / 7739
|
|
23
|
(OMIM)
|
Cleft at the junction of the lobule and helix |
|
|
|
|
2 / 7739
|
|
24
|
(OMIM)
|
Lobule may be separately from the rest of the external ear |
|
|
|
|
2 / 7739
|
|
25
|
(OMIM)
|
Cup pinna |
|
|
|
|
3 / 7739
|
|
26
|
(OMIM)
|
Pre- and post-auricular skin or cartilaginous tags |
|
|
|
|
2 / 7739
|
|
27
|
(OMIM)
|
Stenotic ear canals (30%) |
|
|
|
|
2 / 7739
|
|
28
|
(OMIM)
|
Ear constriction (97%) |
|
|
|
|
2 / 7739
|
|
29
|
(OMIM)
|
Abnormal palate (63%) |
|
|
|
|
2 / 7739
|
|
30
|
(OMIM)
|
Mastication difficulties |
|
|
|
|
2 / 7739
|
|
31
|
(HPO:0200095)
|
Anterior open bite |
|
|
|
|
8 / 7739
|
|
32
|
(OMIM)
|
Posterior crossbite |
|
|
|
|
3 / 7739
|
|
33
|
(OMIM)
|
Respiratory difficulties due to orofacial malformations (36%) |
|
|
|
|
2 / 7739
|
|
34
|
(MedDRA:10041235)
|
Snoring |
|
|
|
|
8 / 7739
|
|
35
|
(OMIM)
|
Mandibular agenesis |
|
|
|
|
3 / 7739
|
|
36
|
(OMIM)
|
Asymmetric mandible |
|
|
|
|
2 / 7739
|
|
37
|
(HPO:0003778)
|
Short mandibular rami |
|
|
|
|
7 / 7739
|
|
38
|
(OMIM)
|
Small mandibular coronoid processes |
|
|
|
|
2 / 7739
|
|
39
|
(OMIM)
|
Temporomandibular joint abnormalities |
|
|
|
|
2 / 7739
|
|
40
|
(OMIM)
|
Ankylosis of the temporomandibular joints |
|
|
|
|
2 / 7739
|