In 3 sisters in a sibship of 9, Ford et al. (1962) observed lipochrome granulation of the histiocytes, pulmonary infiltration, hyperglobulinemia, transient polyarthritis, and susceptibility to infection. No abnormality was seen in plasma cells or lymphocytes. The hyperglobulinemia ... In 3 sisters in a sibship of 9, Ford et al. (1962) observed lipochrome granulation of the histiocytes, pulmonary infiltration, hyperglobulinemia, transient polyarthritis, and susceptibility to infection. No abnormality was seen in plasma cells or lymphocytes. The hyperglobulinemia involved gamma- and alpha(2)-globulins. The authors suggested that the primary defect caused the lipochrome deposition and that the other features were secondary to the deposits. The ages of the sisters were 26, 21 and 16 years.