Juvenile dermatomyositis

General Information (adopted from Orphanet):

Synonyms, Signs: Juvenile DM
Number of Symptoms 42
OrphanetNr: 93672
OMIM Id:
ICD-10: M33.0
UMLs: C0263666
C2931785
MeSH:
MedDRA: 10008521
Snomed: 1212005

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: Infancy
Childhood
Adolescent
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Juvenile idiopathic inflammatory myopathy
 -Rare neurologic disease
Secondary glomerular disease
 -Rare renal disease
Secondary interstitial lung disease specific to childhood associated with a connective tissue disease
 -Rare respiratory disease
Systemic autoimmune disease
 -Rare systemic or rheumatologic disease
Systemic disease with skin involvement
 -Rare skin disease

Symptom Information: Sort by abundance 

1
 (HPO:0000606) Abnormality of the periorbital region Very frequent [Orphanet] 96 / 7739
2
 (HPO:0002015) Dysphagia Occasional [Orphanet] 301 / 7739
3
 (HPO:0002167) Neurological speech impairment Occasional [Orphanet] 308 / 7739
4
 (HPO:0100769) Synovitis Frequent [Orphanet] 86 / 7739
5
 (HPO:0005059) Arthralgia/arthritis Frequent [Orphanet] 141 / 7739
6
 (HPO:0001387) Joint stiffness Occasional [Orphanet] 322 / 7739
7
 (HPO:0002239) Gastrointestinal hemorrhage Occasional [Orphanet] 97 / 7739
8
 (HPO:0002027) Abdominal pain Occasional [Orphanet] 184 / 7739
9
 (HPO:0002019) Constipation Frequent [Orphanet] 194 / 7739
10
 (HPO:0004325) Decreased body weight Occasional [Orphanet] 492 / 7739
11
 (HPO:0000958) Dry skin Very frequent [Orphanet] 152 / 7739
12
 (HPO:0000992) Cutaneous photosensitivity Frequent [Orphanet] 75 / 7739
13
 (HPO:0100585) Telangiectasia of the skin Very frequent [Orphanet] 66 / 7739
14
 (HPO:0001031) Subcutaneous lipoma Very frequent [Orphanet] 112 / 7739
15
 (HPO:0010783) Erythema Very frequent [Orphanet] 138 / 7739
16
 (HPO:0001596) Alopecia Frequent [Orphanet] 162 / 7739
17
 (HPO:0000988) Skin rash Very frequent [Orphanet] 98 / 7739
18
 (HPO:0100579) Mucosal telangiectasiae Very frequent [Orphanet] 10 / 7739
19
 (HPO:0001029) Poikiloderma Frequent [Orphanet] 23 / 7739
20
 (HPO:0000989) Pruritus Frequent [Orphanet] 111 / 7739
21
 (HPO:0200042) Skin ulcer Frequent [Orphanet] 138 / 7739
22
 (HPO:0001697) Abnormality of the pericardium Occasional [Orphanet] 52 / 7739
23
 (HPO:0012089) Arteritis Frequent [Orphanet] 40 / 7739
24
 (HPO:0001677) Coronary artery disease Occasional [Orphanet] 58 / 7739
25
 (HPO:0011025) Abnormality of cardiovascular system physiology Occasional [Orphanet] 41 / 7739
26
 (HPO:0001638) Cardiomyopathy Occasional [Orphanet] 192 / 7739
27
 (HPO:0011675) Arrhythmia Occasional [Orphanet] 226 / 7739
28
 (HPO:0001945) Fever Frequent [Orphanet] 218 / 7739
29
 (HPO:0011227) Elevated C-reactive protein level Very frequent [Orphanet] 55 / 7739
30
 (HPO:0002093) Respiratory insufficiency Occasional [Orphanet] 410 / 7739
31
 (HPO:0002091) Restrictive ventilatory defect Frequent [Orphanet] 46 / 7739
32
 (HPO:0001608) Abnormality of the voice Occasional [Orphanet] 126 / 7739
33
 (HPO:0002206) Pulmonary fibrosis Occasional [Orphanet] 51 / 7739
34
 (HPO:0002960) Autoimmunity Very frequent [Orphanet] 78 / 7739
35
 (HPO:0001252) Muscular hypotonia Very frequent [Orphanet] 990 / 7739
36
 (HPO:0003326) Myalgia Very frequent [Orphanet] 143 / 7739
37
 (HPO:0003394) Muscle cramps Frequent [Orphanet] 106 / 7739
38
 (HPO:0003457) EMG abnormality Occasional [Orphanet] 78 / 7739
39
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739
40
 (HPO:0030350) Erythematous papule Frequent [Orphanet] 123 / 7739
41
 ([DEL]MedDRA:10011224) Cough Occasional [Orphanet] 70 / 7739
42
 (HPO:0030089) Abnormal muscle fiber protein expression Very frequent [Orphanet] 64 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: