Paroxysmal cold hemoglobinuria

General Information (adopted from Orphanet):

Synonyms, Signs: PCH
Donath-Landsteiner hemolytic anemia
Donath-Landsteiner syndrome
Number of Symptoms 9
OrphanetNr: 90035
OMIM Id:
ICD-10: D59.6
UMLs: C0272129
MeSH: C538618
MedDRA:
Snomed: 127057004
62871001

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Orphanet]
Age of onset: Childhood
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Autoimmune hemolytic anemia, cold type
 -Rare hematologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0012086) Abnormal urinary color Very frequent [Orphanet] 19 / 7739
2
 (HPO:0002315) Headache Occasional [Orphanet] 175 / 7739
3
 (HPO:0005059) Arthralgia/arthritis Very frequent [Orphanet] 141 / 7739
4
 (HPO:0002017) Nausea and vomiting Occasional [Orphanet] 134 / 7739
5
 (HPO:0002014) Diarrhea Occasional [Orphanet] 225 / 7739
6
 (HPO:0003010) Prolonged bleeding time Very frequent [Orphanet] 88 / 7739
7
 (HPO:0001878) Hemolytic anemia Very frequent [Orphanet] 83 / 7739
8
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
9
 (HPO:0002205) Recurrent respiratory infections Very frequent [Orphanet] 254 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: