Drug rash with eosinophilia and systemic symptoms

General Information (adopted from Orphanet):

Synonyms, Signs: DRESS syndrome
Drug reaction eosinophilic systemic syndrome
Number of Symptoms 30
OrphanetNr: 139402
OMIM Id:
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Not applicable
[Orphanet]
Age of onset: All ages
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Rare urticaria
 -Rare allergic disease
 -Rare skin disease
Toxic dermatosis
 -Rare skin disease

Symptom Information: Sort by abundance 

1
 (HPO:0000083) Renal insufficiency Occasional [Orphanet] 232 / 7739
2
 (HPO:0001970) Tubulointerstitial nephritis Occasional [Orphanet] 27 / 7739
3
 (HPO:0000100) Nephrotic syndrome Occasional [Orphanet] 83 / 7739
4
 (HPO:0011037) Decreased urine output Occasional [Orphanet] 47 / 7739
5
 (HPO:0011830) Abnormality of oral mucosa Occasional [Orphanet] 47 / 7739
6
 (HPO:0002383) Encephalitis Very frequent [Orphanet] 41 / 7739
7
 (HPO:0009830) Peripheral neuropathy Occasional [Orphanet] 206 / 7739
8
 (HPO:0100646) Thyroiditis Very frequent [Orphanet] 11 / 7739
9
 (HPO:0001396) Cholestasis Occasional [Orphanet] 136 / 7739
10
 (HPO:0006554) Acute hepatic failure Occasional [Orphanet] 20 / 7739
11
 (HPO:0002910) Elevated hepatic transaminases Frequent [Orphanet] 158 / 7739
12
 (HPO:0004325) Decreased body weight Very frequent [Orphanet] 492 / 7739
13
 (HPO:0100665) Angioedema Very frequent [Orphanet] 14 / 7739
14
 (HPO:0000958) Dry skin Very frequent [Orphanet] 152 / 7739
15
 (HPO:0000988) Skin rash Very frequent [Orphanet] 98 / 7739
16
 (HPO:0010783) Erythema Very frequent [Orphanet] 138 / 7739
17
 (HPO:0200039) Pustule Occasional [Orphanet] 20 / 7739
18
 (HPO:0001695) Cardiac arrest Very frequent [Orphanet] 87 / 7739
19
 (HPO:0001637) Abnormality of the myocardium Occasional [Orphanet] 76 / 7739
20
 (HPO:0100827) Lymphocytosis Frequent [Orphanet] 5 / 7739
21
 (HPO:0001879) Abnormality of eosinophils Occasional [Orphanet] 20 / 7739
22
 (HPO:0001945) Fever Very frequent [Orphanet] 218 / 7739
23
 (HPO:0002093) Respiratory insufficiency Occasional [Orphanet] 410 / 7739
24
 (HPO:0002113) Pulmonary infiltrates Frequent [Orphanet] 36 / 7739
25
 (HPO:0002091) Restrictive ventilatory defect Frequent [Orphanet] 46 / 7739
26
 (HPO:0100326) Immunologic hypersensitivity Very frequent [Orphanet] 28 / 7739
27
 (HPO:0002716) Lymphadenopathy Very frequent [Orphanet] 129 / 7739
28
 (MedDRA:10025421) Macule Very frequent [Orphanet] 55 / 7739
29
 ([DEL]MedDRA:10011224) Cough Occasional [Orphanet] 70 / 7739
30
 (HPO:0030350) Erythematous papule Very frequent [Orphanet] 123 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: