Polymyositis
General Information (adopted from Orphanet):
| Synonyms, Signs: |
PM Adult-onset polymyositis |
| Number of Symptoms | 38 |
| OrphanetNr: | 732 |
| OMIM Id: |
|
| ICD-10: |
M33.2 |
| UMLs: |
C0085655 |
| MeSH: |
D017285 |
| MedDRA: |
10036102 |
| Snomed: |
31384009 |
Prevalence, inheritance and age of onset:
| Prevalence: | 6.5 of 100 000 [Orphanet] |
| Inheritance: |
Not applicable [Orphanet] |
| Age of onset: |
Adult Elderly [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Idiopathic inflammatory myopathy
-Rare neurologic disease Secondary glomerular disease -Rare renal disease Systemic autoimmune disease -Rare systemic or rheumatologic disease |
Symptom Information:
|
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(HPO:0000124) | Renal tubular dysfunction | Occasional [Orphanet] | 46 / 7739 | |||
|
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(HPO:0100615) | Ovarian neoplasm | Occasional [Orphanet] | 25 / 7739 | |||
|
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(HPO:0001315) | Reduced tendon reflexes | Occasional [Orphanet] | 160 / 7739 | |||
|
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(HPO:0001288) | Gait disturbance | Occasional [Orphanet] | 318 / 7739 | |||
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(HPO:0002167) | Neurological speech impairment | Occasional [Orphanet] | 308 / 7739 | |||
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(HPO:0100013) | Neoplasm of the breast | Occasional [Orphanet] | 18 / 7739 | |||
|
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(HPO:0005059) | Arthralgia/arthritis | Very frequent [Orphanet] | 141 / 7739 | |||
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(HPO:0100769) | Synovitis | Frequent [Orphanet] | 86 / 7739 | |||
|
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(HPO:0002239) | Gastrointestinal hemorrhage | Occasional [Orphanet] | 97 / 7739 | |||
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(HPO:0002027) | Abdominal pain | Occasional [Orphanet] | 184 / 7739 | |||
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(HPO:0002240) | Hepatomegaly | Occasional [Orphanet] | 467 / 7739 | |||
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(HPO:0002242) | Abnormality of the intestine | Occasional [Orphanet] | 42 / 7739 | |||
|
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(HPO:0002577) | Abnormality of the stomach | Occasional [Orphanet] | 84 / 7739 | |||
|
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(HPO:0002019) | Constipation | Frequent [Orphanet] | 194 / 7739 | |||
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(HPO:0002039) | Anorexia | Frequent [Orphanet] | 62 / 7739 | |||
|
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(HPO:0004325) | Decreased body weight | Frequent [Orphanet] | 492 / 7739 | |||
|
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(HPO:0012089) | Arteritis | Occasional [Orphanet] | 40 / 7739 | |||
|
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(HPO:0001635) | Congestive heart failure | Occasional [Orphanet] | 232 / 7739 | |||
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(HPO:0001638) | Cardiomyopathy | Occasional [Orphanet] | 192 / 7739 | |||
|
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(HPO:0001677) | Coronary artery disease | Occasional [Orphanet] | 58 / 7739 | |||
|
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(HPO:0011675) | Arrhythmia | Occasional [Orphanet] | 226 / 7739 | |||
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(HPO:0001633) | Abnormality of the mitral valve | Occasional [Orphanet] | 69 / 7739 | |||
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(HPO:0011025) | Abnormality of cardiovascular system physiology | Occasional [Orphanet] | 41 / 7739 | |||
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(HPO:0001697) | Abnormality of the pericardium | Occasional [Orphanet] | 52 / 7739 | |||
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(HPO:0004936) | Venous thrombosis | Occasional [Orphanet] | 41 / 7739 | |||
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(HPO:0001945) | Fever | Frequent [Orphanet] | 218 / 7739 | |||
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(HPO:0002206) | Pulmonary fibrosis | Occasional [Orphanet] | 51 / 7739 | |||
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(HPO:0100526) | Neoplasm of the lung | Occasional [Orphanet] | 26 / 7739 | |||
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(HPO:0001608) | Abnormality of the voice | Occasional [Orphanet] | 126 / 7739 | |||
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(HPO:0002091) | Restrictive ventilatory defect | Frequent [Orphanet] | 46 / 7739 | |||
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(HPO:0002093) | Respiratory insufficiency | Frequent [Orphanet] | 410 / 7739 | |||
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(HPO:0002960) | Autoimmunity | Very frequent [Orphanet] | 78 / 7739 | |||
|
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(HPO:0001252) | Muscular hypotonia | Very frequent [Orphanet] | 990 / 7739 | |||
|
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(HPO:0003326) | Myalgia | Very frequent [Orphanet] | 143 / 7739 | |||
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(HPO:0003457) | EMG abnormality | Very frequent [Orphanet] | 78 / 7739 | |||
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(HPO:0001324) | Muscle weakness | Very frequent [Orphanet] | 859 / 7739 | |||
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([DEL]MedDRA:10011224) | Cough | Very frequent [Orphanet] | 70 / 7739 | |||
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(HPO:0030089) | Abnormal muscle fiber protein expression | Very frequent [Orphanet] | 64 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
|---|