Microscopic polyangiitis
General Information (adopted from Orphanet):
| Synonyms, Signs: |
MPA Hypersensitivity angiitis Micropolyangiitis Microscopic polyarteritis |
| Number of Symptoms | 38 |
| OrphanetNr: | 727 |
| OMIM Id: |
|
| ICD-10: |
M31.7 |
| UMLs: |
C0343192 |
| MeSH: |
D055953 |
| MedDRA: |
10063344 |
| Snomed: |
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Prevalence, inheritance and age of onset:
| Prevalence: | No data available. |
| Inheritance: |
Not applicable [Orphanet] |
| Age of onset: |
Adult [Orphanet] |
Disease classification (adopted from Orphanet):
| Parent Diseases: |
Anti-neutrophil cytoplasmic antibody-associated vasculitis
-Rare circulatory system disease -Rare respiratory disease -Rare systemic or rheumatologic disease Secondary glomerular disease -Rare renal disease Systemic inflammatory disease associated with an acquired peripheral neuropathy -Rare neurologic disease |
Symptom Information:
|
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(HPO:0100820) | Glomerulopathy | Very frequent [Orphanet] | 46 / 7739 | |||
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(HPO:0011037) | Decreased urine output | Very frequent [Orphanet] | 47 / 7739 | |||
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(HPO:0000790) | Hematuria | Very frequent [Orphanet] | 106 / 7739 | |||
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(HPO:0000083) | Renal insufficiency | Very frequent [Orphanet] | 232 / 7739 | |||
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(HPO:0000421) | Epistaxis | Occasional [Orphanet] | 85 / 7739 | |||
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(HPO:0000246) | Sinusitis | Occasional [Orphanet] | 73 / 7739 | |||
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(HPO:0100533) | Inflammatory abnormality of the eye | Occasional [Orphanet] | 70 / 7739 | |||
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(HPO:0008046) | Abnormality of the retinal vasculature | Occasional [Orphanet] | 41 / 7739 | |||
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(HPO:0009830) | Peripheral neuropathy | Very frequent [Orphanet] | 206 / 7739 | |||
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(HPO:0000763) | Sensory neuropathy | Occasional [Orphanet] | 78 / 7739 | |||
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(HPO:0100769) | Synovitis | Occasional [Orphanet] | 86 / 7739 | |||
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(HPO:0005059) | Arthralgia/arthritis | Frequent [Orphanet] | 141 / 7739 | |||
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(HPO:0005244) | Gastrointestinal infarctions | Frequent [Orphanet] | 14 / 7739 | |||
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(HPO:0002017) | Nausea and vomiting | Frequent [Orphanet] | 134 / 7739 | |||
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(HPO:0002239) | Gastrointestinal hemorrhage | Frequent [Orphanet] | 97 / 7739 | |||
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(HPO:0100592) | Peritoneal abscess | Frequent [Orphanet] | 10 / 7739 | |||
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(HPO:0002014) | Diarrhea | Frequent [Orphanet] | 225 / 7739 | |||
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(HPO:0001733) | Pancreatitis | Occasional [Orphanet] | 46 / 7739 | |||
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(HPO:0002242) | Abnormality of the intestine | Frequent [Orphanet] | 42 / 7739 | |||
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(HPO:0002027) | Abdominal pain | Frequent [Orphanet] | 184 / 7739 | |||
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(HPO:0001031) | Subcutaneous lipoma | Occasional [Orphanet] | 112 / 7739 | |||
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(HPO:0200042) | Skin ulcer | Frequent [Orphanet] | 138 / 7739 | |||
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(HPO:0010783) | Erythema | Very frequent [Orphanet] | 138 / 7739 | |||
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(HPO:0001933) | Subcutaneous hemorrhage | Frequent [Orphanet] | 50 / 7739 | |||
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(HPO:0000988) | Skin rash | Very frequent [Orphanet] | 98 / 7739 | |||
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(HPO:0000965) | Cutis marmorata | Occasional [Orphanet] | 46 / 7739 | |||
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(HPO:0001697) | Abnormality of the pericardium | Occasional [Orphanet] | 52 / 7739 | |||
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(HPO:0012089) | Arteritis | Very frequent [Orphanet] | 40 / 7739 | |||
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(HPO:0011675) | Arrhythmia | Occasional [Orphanet] | 226 / 7739 | |||
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(HPO:0001635) | Congestive heart failure | Occasional [Orphanet] | 232 / 7739 | |||
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(HPO:0004936) | Venous thrombosis | Frequent [Orphanet] | 41 / 7739 | |||
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(HPO:0001945) | Fever | Very frequent [Orphanet] | 218 / 7739 | |||
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(HPO:0011227) | Elevated C-reactive protein level | Very frequent [Orphanet] | 55 / 7739 | |||
|
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(HPO:0100758) | Gangrene | Occasional [Orphanet] | 25 / 7739 | |||
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(HPO:0002105) | Hemoptysis | Very frequent [Orphanet] | 30 / 7739 | |||
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(HPO:0002088) | Abnormality of lung morphology | Very frequent [Orphanet] | 11 / 7739 | |||
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(HPO:0002960) | Autoimmunity | Very frequent [Orphanet] | 78 / 7739 | |||
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(HPO:0003326) | Myalgia | Frequent [Orphanet] | 143 / 7739 |
Associated genes:
ClinVar (via SNiPA)
| Gene symbol | Variation | Clinical significance | Reference |
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