Cold agglutinin disease

General Information (adopted from Orphanet):

Synonyms, Signs: CAS
CAD
Chronic cold agglutinin disease
Cold agglutinin syndrome
Number of Symptoms 12
OrphanetNr: 56425
OMIM Id:
ICD-10: D59.1
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Autoimmune hemolytic anemia, cold type
 -Rare hematologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0012086) Abnormal urinary color Occasional [Orphanet] 19 / 7739
2
 (HPO:0002315) Headache Occasional [Orphanet] 175 / 7739
3
 (HPO:0005059) Arthralgia/arthritis Very frequent [Orphanet] 141 / 7739
4
 (HPO:0002014) Diarrhea Occasional [Orphanet] 225 / 7739
5
 (HPO:0002240) Hepatomegaly Occasional [Orphanet] 467 / 7739
6
 (HPO:0001744) Splenomegaly Occasional [Orphanet] 337 / 7739
7
 (HPO:0002017) Nausea and vomiting Occasional [Orphanet] 134 / 7739
8
 (HPO:0000980) Pallor Very frequent [Orphanet] 52 / 7739
9
 (HPO:0001878) Hemolytic anemia Very frequent [Orphanet] 83 / 7739
10
 (HPO:0002960) Autoimmunity Very frequent [Orphanet] 78 / 7739
11
 (HPO:0002716) Lymphadenopathy Occasional [Orphanet] 129 / 7739
12
 (HPO:0001324) Muscle weakness Very frequent [Orphanet] 859 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: