Waldenström macroglobulinemia

General Information (adopted from Orphanet):

Synonyms, Signs: Lymphoplasmacytic immunocytoma
Lymphoplasmacytic lymphoma
Number of Symptoms 49
OrphanetNr: 33226
OMIM Id: 153600
610430
ICD-10: C88.0
UMLs: C0024419
MeSH: D008258
MedDRA: 10047801
Snomed: 190817009
190818004
35562000

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Multifactorial
[Orphanet]
Age of onset: Adult
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Indolent B-cell non-Hodgkin lymphoma
 -Rare hematologic disease
 -Rare oncologic disease
Malignant lymphoma with peripheral neuropathy
 -Rare neurologic disease

Symptom Information: Sort by abundance 

1
 (HPO:0000083) Renal insufficiency Occasional [Orphanet] 232 / 7739
2
 (HPO:0000421) Epistaxis Occasional [Orphanet] 85 / 7739
3
 (HPO:0000606) Abnormality of the periorbital region Occasional [Orphanet] 96 / 7739
4
 (HPO:0000225) Gingival bleeding Frequent [Orphanet] 28 / 7739
5
 (HPO:0000520) Proptosis Occasional [Orphanet] 192 / 7739
6
 (HPO:0008046) Abnormality of the retinal vasculature Occasional [Orphanet] 41 / 7739
7
 (HPO:0000365) Hearing impairment Occasional [Orphanet] 539 / 7739
8
 (HPO:0009830) Peripheral neuropathy Occasional [Orphanet] 206 / 7739
9
 (HPO:0001271) Polyneuropathy 56 / 7739
10
 (HPO:0006824) Cranial nerve paralysis Occasional [Orphanet] 81 / 7739
11
 (HPO:0004372) Reduced consciousness/confusion Occasional [Orphanet] 73 / 7739
12
 (HPO:0002066) Gait ataxia Occasional [Orphanet] 327 / 7739
13
 (HPO:0002141) Gait imbalance Occasional [Orphanet] 55 / 7739
14
 (HPO:0002315) Headache Occasional [Orphanet] 175 / 7739
15
 (HPO:0002354) Memory impairment Occasional [Orphanet] 63 / 7739
16
 (HPO:0011442) Abnormality of central motor function Occasional [Orphanet] 76 / 7739
17
 (HPO:0002024) Malabsorption Occasional [Orphanet] 142 / 7739
18
 (HPO:0002240) Hepatomegaly Occasional [Orphanet] 467 / 7739
19
 (HPO:0002039) Anorexia Occasional [Orphanet] 62 / 7739
20
 (HPO:0001744) Splenomegaly Occasional [Orphanet] 337 / 7739
21
 (HPO:0002239) Gastrointestinal hemorrhage Occasional [Orphanet] 97 / 7739
22
 (HPO:0001933) Subcutaneous hemorrhage Occasional [Orphanet] 50 / 7739
23
 (HPO:0000980) Pallor Frequent [Orphanet] 52 / 7739
24
 (HPO:0001025) Urticaria Occasional [Orphanet] 73 / 7739
25
 (HPO:0000965) Cutis marmorata Occasional [Orphanet] 46 / 7739
26
 (HPO:0001635) Congestive heart failure Occasional [Orphanet] 232 / 7739
27
 (HPO:0012089) Arteritis Occasional [Orphanet] 40 / 7739
28
 (HPO:0002140) Ischemic stroke Occasional [Orphanet] 70 / 7739
29
 (HPO:0012145) Abnormality of multiple cell lineages in the bone marrow Very frequent [Orphanet] 11 / 7739
30
 (HPO:0003347) Impaired lymphocyte transformation with phytohemagglutinin 6 / 7739
31
 (HPO:0004377) Hematological neoplasm Very frequent [Orphanet] 12 / 7739
32
 (HPO:0001874) Abnormality of neutrophils Frequent [Orphanet] 47 / 7739
33
 (HPO:0001897) Normocytic anemia Frequent [Orphanet] 7 / 7739
34
 (HPO:0001909) Leukemia Very frequent [Orphanet] occasional [HPO:probinson] 46 / 7739
35
 (HPO:0005508) Waldenstrom macroglobulinemia 2 / 7739
36
 (HPO:0003459) Polyclonal elevation of IgM 4 / 7739
37
 (HPO:0100724) Hypercoagulability Frequent [Orphanet] 15 / 7739
38
 (HPO:0002665) Lymphoma occasional [HPO:probinson] 60 / 7739
39
 (HPO:0001945) Fever Occasional [Orphanet] 218 / 7739
40
 (HPO:0011227) Elevated C-reactive protein level Occasional [Orphanet] 55 / 7739
41
 (HPO:0010741) Edema of the lower limbs Occasional [Orphanet] 34 / 7739
42
 (HPO:0002093) Respiratory insufficiency Frequent [Orphanet] 410 / 7739
43
 (HPO:0002113) Pulmonary infiltrates Occasional [Orphanet] 36 / 7739
44
 (HPO:0002103) Abnormality of the pleura Occasional [Orphanet] 58 / 7739
45
 (HPO:0100778) Cryoglobulinemia Occasional [Orphanet] 2 / 7739
46
 (HPO:0010978) Abnormality of immune system physiology Occasional [Orphanet] 148 / 7739
47
 (HPO:0002716) Lymphadenopathy Occasional [Orphanet] 129 / 7739
48
 (HPO:0001324) Muscle weakness Occasional [Orphanet] 859 / 7739
49
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: