Feingold syndrome

General Information (adopted from Orphanet):

Synonyms, Signs: MMT
ODED syndrome
MODED syndrome
Microcephaly - intellectual deficit - tracheoesophageal fistula
Oculo-digito-esophageal-duodenal syndrome
Microcephaly - oculo-digito-esophageal-duodenal syndrome
Brunner-Winter syndrome
Digital anomalies with short palpebral fissures and atresia of esophagus or duodenum
Number of Symptoms 54
OrphanetNr: 1305
OMIM Id: 164280
614326
ICD-10: Q87.8
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: < 50 cases [Orphanet]
Inheritance: Autosomal dominant
[Orphanet]
Age of onset: Neonatal
[Orphanet]

Disease classification (adopted from Orphanet):

Parent Diseases: Genetic multiple congenital anomalies/dysmorphic syndrome - variable intellectual deficit
 -Rare genetic disease
Genetic syndromic esophageal malformation
 -Rare abdominal surgical disease
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
Multiple congenital anomalies/dysmorphic syndrome - variable intellectual deficit
 -Rare developmental defect during embryogenesis
Nonsyndromic respiratory or mediastinal malformation
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
 -Rare surgical thoracic disease
Syndrome with brachydactyly
 -Rare bone disease
 -Rare developmental defect during embryogenesis
Syndromic esophageal malformation
 -Rare abdominal surgical disease
 -Rare developmental defect during embryogenesis
 -Rare genetic disease
Syndromic gastroduodenal malformation
 -Rare abdominal surgical disease
 -Rare developmental defect during embryogenesis
 -Rare genetic disease

Symptom Information: Sort by abundance 

1
 (HPO:0005280) Depressed nasal bridge Frequent [Orphanet] 381 / 7739
2
 (HPO:0000325) Triangular face 91 / 7739
3
 (HPO:0000463) Anteverted nares Frequent [Orphanet] 305 / 7739
4
 (HPO:0000324) Facial asymmetry 57 / 7739
5
 (HPO:0012471) Thick vermilion border 115 / 7739
6
 (HPO:0000286) Epicanthus 371 / 7739
7
 (HPO:0000269) Prominent occiput 43 / 7739
8
 (HPO:0000581) Blepharophimosis Very frequent [Orphanet] 197 / 7739
9
 (HPO:0000277) Abnormality of the mandible Frequent [Orphanet] 394 / 7739
10
 (HPO:0000218) High palate 356 / 7739
11
 (HPO:0000431) Wide nasal bridge 290 / 7739
12
 (HPO:0000437) Depressed nasal tip 17 / 7739
13
 (HPO:0000232) Everted lower lip vermilion 90 / 7739
14
 (HPO:0000202) Oral cleft Occasional [Orphanet] 120 / 7739
15
 (HPO:0000252) Microcephaly Very frequent [Orphanet] 832 / 7739
16
 (HPO:0000237) Small anterior fontanelle 10 / 7739
17
 (HPO:0000347) Micrognathia 426 / 7739
18
 (HPO:0000582) Upslanted palpebral fissure 185 / 7739
19
 (HPO:0000369) Low-set ears 372 / 7739
20
 (HPO:0000356) Abnormality of the outer ear Frequent [Orphanet] 85 / 7739
21
 (HPO:0000407) Sensorineural hearing impairment Occasional [Orphanet] 524 / 7739
22
 (HPO:0000365) Hearing impairment 539 / 7739
23
 (HPO:0000358) Posteriorly rotated ears 163 / 7739
24
 (HPO:0001605) Vocal cord paralysis 13 / 7739
25
 (HPO:0001328) Specific learning disability 114 / 7739
26
 (HPO:0001249) Intellectual disability 1089 / 7739
27
 (HPO:0004279) Short palm Very frequent [Orphanet] 323 / 7739
28
 (HPO:0001831) Short toe 52 / 7739
29
 (HPO:0004209) Clinodactyly of the 5th finger Very frequent [Orphanet] 288 / 7739
30
 (HPO:0009568) Aplasia/Hypoplasia of the middle phalanx of the 2nd finger 4 / 7739
31
 (HPO:0001770) Toe syndactyly Frequent [Orphanet] 149 / 7739
32
 (HPO:0001822) Hallux valgus Frequent [Orphanet] 70 / 7739
33
 (HPO:0009466) Radial deviation of finger Very frequent [Orphanet] 101 / 7739
34
 (HPO:0009161) Aplasia/Hypoplasia of the middle phalanx of the 5th finger 4 / 7739
35
 (HPO:0004691) 2-3 toe syndactyly 56% [HPO:probinson] 50 / 7739
36
 (HPO:0003312) Abnormal form of the vertebral bodies Occasional [Orphanet] 172 / 7739
37
 (HPO:0004692) 4-5 toe syndactyly 86% [HPO:probinson] 6 / 7739
38
 (HPO:0001558) Decreased fetal movement 74 / 7739
39
 (HPO:0001561) Polyhydramnios 191 / 7739
40
 (HPO:0001743) Abnormality of the spleen Occasional [Orphanet] 37 / 7739
41
 (HPO:0001747) Accessory spleen 8 / 7739
42
 (HPO:0001746) Asplenia 19 / 7739
43
 (HPO:0002032) Esophageal atresia 19 / 7739
44
 (HPO:0002247) Duodenal atresia 13 / 7739
45
 (HPO:0002575) Tracheoesophageal fistula Occasional [Orphanet] 54 / 7739
46
 (HPO:0100867) Duodenal stenosis Occasional [Orphanet] 29 / 7739
47
 (HPO:0001748) Polysplenia 14 / 7739
48
 (HPO:0001734) Annular pancreas Occasional [Orphanet] 10 / 7739
49
 (HPO:0004322) Short stature Frequent [Orphanet] 1232 / 7739
50
 (HPO:0001643) Patent ductus arteriosus Occasional [Orphanet] 228 / 7739
51
 (HPO:0003220) Abnormality of chromosome stability Occasional [Orphanet] 98 / 7739
52
 (HPO:0012745) Short palpebral fissure 47 / 7739
53
 (HPO:0012758) Neurodevelopmental delay Frequent [Orphanet] 949 / 7739
54
 (HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information: