Weissman et al. (1963) described an arthrogryposis-like picture consisting of flexion contractures at the elbows or knees and no dislocation of the hips. Lebenthal et al. (1970) reported further observations of the kindred studied by Weissman et al. ... Weissman et al. (1963) described an arthrogryposis-like picture consisting of flexion contractures at the elbows or knees and no dislocation of the hips. Lebenthal et al. (1970) reported further observations of the kindred studied by Weissman et al. (1963). They found 23 cases in an inbred Arab group. In a repeat study of this kindred, Jaber et al. (1995) identified 40 affected individuals. Five of the 6 individuals who were originally reported as having congenital and lethal heart defects were limited to one sibship. None of the newly identified cases had heart defect or any associated malformation. Neurologic examination and electrophysiologic studies demonstrated a neuropathic (i.e., nonmyopathic) type of arthrogryposis. Penetrance may be incomplete in females. Shohat et al. (1997) found that the most common clinical features in this family were flexion contractures of the elbows and knees and marked equinovarus. Many patients learned how to cope adequately with their handicap, and most of the adult patients were employed, some as carpenters (a common profession in this clan). Females were less affected than males; the male/female ratio was 2 to 1 and the authors concluded that there is incomplete penetrance of the disorder in females. From Israel, Krugliak et al. (1978) presented 3 autopsies of neuropathic AMC in Bedouin Arabs and commented on 2 other cases. This is presumably the same disorder as that reported by Lebenthal et al. (1970). One infant showed, in addition to depletion of spinal motor neurons, total absence of muscle spindles.