X-linked lymphoproliferative disease
General Information (adopted from Orphanet):
Synonyms, Signs: |
XLP Purtilo syndrome Duncan disease |
Number of Symptoms | 15 |
OrphanetNr: | 2442 |
OMIM Id: |
300635
308240 |
ICD-10: |
D82.3 |
UMLs: |
C0549463 |
MeSH: |
D008232 |
MedDRA: |
10068348 |
Snomed: |
77121009 |
Prevalence, inheritance and age of onset:
Prevalence: | 0.05 of 100 000 [Orphanet] |
Inheritance: |
X-linked recessive [Orphanet] |
Age of onset: |
Childhood [Orphanet] |
Disease classification (adopted from Orphanet):
Parent Diseases: |
Lymphoproliferative syndrome
-Rare genetic disease -Rare immune disease -Rare oncologic disease Primary hemophagocytic lymphohistiocytosis -Rare genetic disease -Rare immune disease |
Symptom Information:
|
(HPO:0002240) | Hepatomegaly | Frequent [Orphanet] | 467 / 7739 | |||
|
(HPO:0012115) | Hepatitis | 8/9 [HPO:probinson] | 24 / 7739 | |||
|
(HPO:0001744) | Splenomegaly | Frequent [Orphanet] 9/10 [HPO:probinson] | 20489057 | IBIS | 337 / 7739 | |
|
(HPO:0010701) | Abnormal immunoglobulin level | Frequent [Orphanet] | 49 / 7739 | |||
|
(HPO:0012156) | Hemophagocytosis | 4/9 [HPO:probinson] | 9 / 7739 | |||
|
(HPO:0002665) | Lymphoma | Frequent [Orphanet] | 60 / 7739 | |||
|
(HPO:0011900) | Hypofibrinogenemia | 7/8 [HPO:probinson] | 8 / 7739 | |||
|
(HPO:0004313) | Decreased antibody level in blood | 47 / 7739 | ||||
|
(HPO:0001903) | Anemia | Occasional [Orphanet] | 289 / 7739 | |||
|
(HPO:0002155) | Hypertriglyceridemia | 7/8 [HPO:probinson] | 67 / 7739 | |||
|
(HPO:0001945) | Fever | 9/10 [HPO:probinson] | 218 / 7739 | |||
|
(HPO:0003281) | Increased serum ferritin | 7/8 [HPO:probinson] | 32 / 7739 | |||
|
(HPO:0002716) | Lymphadenopathy | Frequent [Orphanet] | 129 / 7739 | |||
|
(HPO:0005352) | Severe T-cell immunodeficiency | Very frequent [Orphanet] | 20 / 7739 | |||
|
(HPO:0001417) | X-linked inheritance | 173 / 7739 |
Associated genes:
ClinVar (via SNiPA)
Gene symbol | Variation | Clinical significance | Reference |
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