It had been suggested for many decades that disruption of GABAergic neurotransmission mediated by gamma-aminobutyric acid (GABA) is involved in epilepsy (Olsen et al., 1999). In a family in which individuals had both childhood absence epilepsy and febrile ... It had been suggested for many decades that disruption of GABAergic neurotransmission mediated by gamma-aminobutyric acid (GABA) is involved in epilepsy (Olsen et al., 1999). In a family in which individuals had both childhood absence epilepsy and febrile seizures, Wallace et al. (2001) identified a mutation in the GABRG2 gene (137164.0002).