|
1,944
|
| 15222 |
Csf3
|
|
decreases_activity of
|
quiescence
|
of d-HSC (LRC) by inducing injury signals
|
in vivo
|
| 16212 |
BM injury
|
|
decreases_activity of
|
quiescence
|
of d-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
in vivo
|
| 16275 |
BM homeostasis
|
|
increases_activity of
|
quiescence
|
of d-HSC (LRC-HSC, CD34-CD150+CD48-CD135-KSL)
|
in vivo
|
|
19062086
|
|
1,995
|
| 15867 |
transforming growth factor beta receptor signaling pathway
|
|
affects_activity of
|
quiescence
|
|
|
|
20207229
|
|
2,067
|
| 16651 |
Itch
|
|
increases_activity of
|
quiescence
|
|
in vivo
|
|
21478879
|
|
2,068
|
| 16654 |
Notch1
|
|
decreases_activity of
|
quiescence
|
if the intracellular domain of Notch1 is overexpressed
|
|
|
21478879
|
|
2,102
|
| 17152 |
Tek
|
|
increases_activity of
|
quiescence
|
through interaction with the niche
|
|
|
16151515
|
|
2,569
|
| 24173 |
5-FU
|
|
decreases_activity of
|
quiescence
|
|
in vivo
|
| 37950 |
Mpl
|
|
increases_activity of
|
quiescence
|
|
in vivo
|
|
18371409
|
|
2,622
|
| 24910 |
TPO/MPL signaling
|
|
increases_activity of
|
quiescence
|
in HSC (CD34-Mpl+KSL)
|
in vivo
|
| 24913 |
Thpo
|
|
increases_activity of
|
quiescence
|
|
in vivo
|
| 24915 |
TPO/MPL signaling
|
|
increases_activity of
|
quiescence
|
in LT-HSC (SP,KSL)
|
in vivo
|
| 24917 |
Mpl
|
|
increases_activity of
|
quiescence
|
in HSC (CD34-Mpl+KSL)
|
in vivo
|
|
18371409
|
|
2,626
|
| 24949 |
Thpo
|
|
increases_activity of
|
quiescence
|
in LT-HSC (CD34-FLT3-KSL)
|
in vivo
|
|
18371408
|
|
2,628
|
| 25032 |
Tie2/Ang1 signaling
|
|
increases_activity of
|
quiescence
|
in LT-HSC (Tie2+SP,KSL), overexpressing Ang1; 67% of the stem cells are in G0 phase of the cell cycle
|
in vivo
|
| 27951 |
Angpt1
|
|
increases_activity of
|
quiescence
|
in LT-HSC (Tie2+SP,KSL)
|
in vivo
|
| 37945 |
Tek
|
|
increases_activity of
|
quiescence
|
compared to Tie2-cells; more than 90% of the cells after 5FU treatment are in G0 phase
|
in vivo
|
|
15260986
|
|
2,656
|
| 25077 |
Sh2b3
|
|
decreases_activity of
|
quiescence
|
compared to WT or Mpl-/- cells. It is suggested that Lnk controls HSC quiescence through Mpl. and downregulation of JAK2
|
in vivo
|
| 25078 |
Mpl
|
|
increases_activity of
|
quiescence
|
compared to WT or Lnk-/- cells
|
in vivo
|
|
18618018
|
|
2,756
|
| 30917 |
BMP signaling pathway
|
|
decreases_activity of
|
quiescence
|
|
in vivo
|
| 37819 |
Bmpr1a
|
|
decreases_activity of
|
quiescence
|
|
in vivo
|
|
14574412
|
|
2,761
|
| 25581 |
CAR cell
|
|
decreases_activity of
|
quiescence
|
of LT-HSC (CD34-CD150+CD48-KSL)
|
in vivo
|
|
20850355
|
|
2,766
|
| 30461 |
CXCL12/CXCR4 signaling
|
|
increases_activity of
|
quiescence
|
|
|
| 30462 |
Cxcr4
|
|
increases_activity of
|
quiescence
|
|
|
|
17174120
|
|
2,834
|
| 26172 |
canonical Wnt signaling pathway
|
|
increases_activity of
|
quiescence
|
of HSC (CD34(lo)KSL)
|
in vivo
|
| 26320 |
Dkk1
|
|
decreases_activity of
|
quiescence
|
of HSC (CD34(lo)KSL)
|
in vivo
|
|
18371452
|
|
2,878
|
| 26517 |
Wif1
|
|
decreases_activity of
|
quiescence
|
in HSC (KSL); if Wif1 is overexpressed in osteoblasts
|
in vivo
|
|
21652676
|
|
2,895
|
| 26598 |
Spp1
|
|
increases_activity of
|
quiescence
|
of HSC (KSL)
|
in vivo
|
|
15845900
|
|
3,111
|
| 28570 |
Stat5a
|
|
increases_activity of
|
quiescence
|
within the HSC (CD34-KSL) pool
|
in vivo
|
|
19258595
|
|
3,125
|
| 38401 |
Nfya
|
|
decreases_activity of
|
quiescence
|
in BM progenitors and precursors. Quiescent HSCs do not depend on NF-Y activity.
|
in vivo
|
|
22072554
|
|
3,148
|
| 28992 |
Kit
|
|
increases_activity of
|
quiescence
|
in LT-HSC (CD34-Flk2-KSL)
|
|
|
18250409
|
|
3,150
|
| 29008 |
Cdkn1a
|
|
increases_activity of
|
quiescence
|
of BM (lin-) cells
|
in vivo
|
|
10710306
|
|
3,155
|
| 37915 |
Tgfb1
|
|
increases_activity of
|
quiescence
|
Inhibtion of the cell cycle is independent of p21 or p27
|
in vitro
|
|
11739168
|
|
3,186
|
| 29261 |
Ptk2
|
|
increases_activity of
|
quiescence
|
in KSL cells
|
|
|
22155722
|
|
3,201
|
| 29412 |
Cdh2
|
|
increases_activity of
|
quiescence
|
of HSC (KSL) or HSC (SP,KSL)
|
in vitro
|
|
20207221
|
|
3,205
|
| 29518 |
Skp2
|
|
increases_activity of
|
quiescence
|
in LT-HSC (CD34-Flk2-KSL)
|
in vivo
|
|
21931116
|
|
3,207
|
| 30560 |
Skp2
|
|
decreases_activity of
|
quiescence
|
in HSC (KSL)
|
in vivo
|
|
21502543
|
|
3,322
|
| 30531 |
Cxcr4
|
|
increases_activity of
|
quiescence
|
|
in vivo
|
| 30532 |
CXCL12/CXCR4 signaling
|
|
increases_activity of
|
quiescence
|
|
in vivo
|
| 30533 |
Cxcl12
|
|
increases_activity of
|
quiescence
|
|
in vitro
|
|
18378795
|
|
3,403
|
| 31617 |
Angptl3
|
|
increases_activity of
|
quiescence
|
of HSC (CD150+KSL)
|
in vivo
|
| 31618 |
Angptl3
|
|
increases_activity of
|
quiescence
|
of LT-HSC (CD34-CD135-KSL)
|
in vivo
|
| 31652 |
Ikzf1
|
|
decreases_activity of
|
quiescence
|
in HSC (KSL)
|
in vivo
|
|
20959605
|
|
3,472
|
| 32340 |
Mad1l1
|
|
decreases_activity of
|
quiescence
|
HSC (KSL) cells of Mad1-/- and p27(Kip1)-/- double knockout mice are even mor quiescent than Mad1-/- knockout mice. Under conditions of stress the cell cycle activity is enhanced in Mad1 and p27Kip1 knockout mice.
|
in vivo
|
| 32346 |
Cdkn1b
|
|
decreases_activity of
|
quiescence
|
HSC (KSL) cells of Mad1-/- and p27(Kip1)-/- double knockout mice are even more quiescent than Mad1-/- knockout mice. Under conditions of stress the cell cycle activity is enhanced in Mad1 and p27Kip1 knockout mice.
|
in vivo
|
|
15654333
|
|
3,537
|
| 32941 |
Celsr2
|
|
increases_activity of
|
quiescence
|
of LT-HSC (CD34-CD135-KSL). Homing was not affected by knockout of Fmi or Fz8, nor did apoptosis increase
|
in vivo
|
| 32942 |
Fzd8
|
|
increases_activity of
|
quiescence
|
of LT-HSC (CD34-CD135-KSL). Homing was not affected by knockout of Fmi or Fz8, nor did apoptosis increase
|
in vivo
|
| 33442 |
non-canonical Wnt signaling pathway
|
|
increases_activity of
|
quiescence
|
of LT-HSC (CD34-CD135-KSL). Homing was not affected by knockout of Fmi or Fz8, nor did apoptosis increase
|
in vivo
|
|
22817897
|
|
3,587
|
| 33633 |
Gata3
|
|
decreases_activity of
|
quiescence
|
|
in vivo
|
|
22267605
|
HSC