|
2,067
|
| 16659 |
Itch
|
|
decreases_quantity of
|
Notch1
|
in HSC (CD150+CD48-KSL); by ubiquitination of Notch1, resulting in increased proteasomal degradation of Notch1
|
in vivo
|
| 27602 |
Itch
|
|
decreases_activity of
|
Notch signaling pathway
|
|
in vivo
|
| 27603 |
Itch
|
|
interacts (colocalizes) with
|
Notch1
|
|
in vivo
|
|
21478879
|
|
2,819
|
| 25977 |
Notch1
|
|
interacts (colocalizes) with
|
Jag1
|
|
|
| 25979 |
Notch1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 25980 |
Jag1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 25981 |
osteoblast (osteopontin+)
|
|
increases_quantity of
|
Jag1
|
|
|
| 25984 |
HSC (KSL)
|
|
increases_quantity of
|
Notch1
|
after PPR activation
|
in vivo
|
| 26068 |
Notch signaling pathway
|
|
increases_quantity of
|
HSC (KSL)
|
|
|
| 26089 |
Notch signaling pathway
|
|
increases_activity of
|
self-renewal
|
of HSCs
|
|
| 28808 |
PTH signaling
|
|
increases_expression of
|
Jag1
|
in osteoblasts
|
|
| 31811 |
Notch1
|
|
interacts (colocalizes) with
|
Dll1
|
|
|
|
14574413
|
|
3,188
|
| 29271 |
Ctnnb1
|
|
increases_expression of
|
Notch1
|
in HSC (Thy1(lo)KSL)
|
|
| 29273 |
HSC (Thy1(lo)KSL)
|
|
increases_expression of
|
Notch1
|
Expression is further inceased by addition of beta-catenin
|
|
| 29275 |
canonical Wnt signaling pathway
|
|
increases_expression of
|
Notch1
|
in HSC (Thy1(lo)KSL)
|
|
|
12717450
|
|
3,403
|
| 31635 |
BM cell (CD45-SSEA4+Angpt3+)
|
|
increases_expression of
|
Dll1
|
in comparison to CD45-SSEA4+ cells
|
|
| 31649 |
Angptl3
|
|
decreases_expression of
|
Ikzf1
|
in LT-HSC (CD34-CD135-KSL)
|
in vivo
|
| 31658 |
Notch signaling pathway
|
|
increases_expression of
|
Hes1
|
|
|
| 31659 |
Dll1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 31660 |
Jag1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 31661 |
Ikzf1
|
|
decreases_activity of
|
Notch signaling pathway
|
in LT-HSC (CD34-CD135-KSL)
|
|
| 31664 |
Angptl3
|
|
increases_activity of
|
Notch signaling pathway
|
in LT-HSC (CD34-CD135-KSL)
|
|
| 31938 |
Jag1
|
|
interacts (colocalizes) with
|
Notch1
|
|
|
|
20959605
|
|
3,421
|
| 31812 |
Notch1
|
|
increases_quantity of
|
HSC (Sca1+Lin-)
|
in BM
|
in vivo
|
| 31916 |
Notch1
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31917 |
Notch1
|
|
increases_activity of
|
self-renewal
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31924 |
Notch1
|
|
increases_activity of
|
repopulation, lymphoid-biased
|
|
in vivo
|
| 31925 |
Notch signaling pathway
|
|
increases_quantity of
|
HSC (Sca1+Lin-)
|
in BM
|
in vivo
|
| 31926 |
Notch signaling pathway
|
|
increases_activity of
|
repopulation >16 weeks
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31927 |
Notch signaling pathway
|
|
increases_activity of
|
self-renewal
|
of HSC (Sca1+Lin-)
|
in vivo
|
| 31928 |
Notch signaling pathway
|
|
increases_activity of
|
repopulation, lymphoid-biased
|
|
in vivo
|
| 31929 |
Notch signaling pathway
|
|
decreases_activity of
|
repopulation, myeloid-biased
|
|
in vivo
|
| 31957 |
Notch signaling pathway
|
|
decreases_activity of
|
hematopoietic stem cell differentiation
|
of HSC (Sca1+Lin-)
|
in vivo
|
|
11895769
|
|
3,433
|
| 31949 |
Hes1
|
|
increases_quantity of
|
HSC (CD34-SP,KSL)
|
|
in vivo
|
| 31951 |
Hes1
|
|
increases_activity of
|
repopulation <12 weeks
|
|
in vivo
|
| 31954 |
Hes1
|
|
increases_activity of
|
self-renewal
|
|
in vivo
|
|
12406868
|
|
3,436
|
| 31960 |
Jag1
|
NOT |
affects_activity of
|
repopulation >16 weeks
|
under steady-state conditions
|
in vivo
|
|
15550486
|
|
3,594
|
| 33690 |
Junb
|
|
increases_expression of
|
Notch1
|
in in HSC (CD135-KSL)
|
|
| 33691 |
Junb
|
|
increases_expression of
|
Hes1
|
in in HSC (CD135-KSL)
|
|
| 33692 |
Junb
|
|
increases_expression of
|
Hes5
|
in in HSC (CD135-KSL)
|
|
| 33696 |
HSC (CD135-KSL)
|
|
increases_expression of
|
Notch1
|
|
|
| 33699 |
HSC (CD150+CD48-CD135-KSL)
|
|
increases_expression of
|
Hes1
|
|
|
| 33700 |
Junb
|
|
increases_expression of
|
Hes1
|
HSC (CD150+CD48-CD135-KSL)
|
|
| 33701 |
Junb
|
|
increases_expression of
|
Hes1
|
in HSC (CD150+CD48-CD135-KSL)
|
|
| 33702 |
Junb
|
|
increases_activity of
|
Notch signaling pathway
|
in HSC (CD150+CD48-CD135-KSL) or HSC (CD135-KSL); In JunB-deficient HSCs induction of Hes1 expression is impaired.
|
in vitro
|
| 33730 |
Notch signaling pathway
|
|
decreases_activity of
|
myeloid cell differentiation
|
in HSC (CD150+CD48-CD135-KSL); JunB-deficient cells cannot respond to Notch and Tgfbeta signals.
|
in vitro
|
|
19345332
|
|
3,811
|
| 38118 |
Dll4
|
|
interacts (colocalizes) with
|
Notch1
|
to induce Notch signaling
|
|
| 38119 |
Notch1
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 38120 |
Dll4
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 38122 |
Zbtb7a
|
|
decreases_activity of
|
Notch signaling pathway
|
by down-regulation of Dll4 in erythroblasts
|
|
|
23134786
|
|
3,857
|
| 38770 |
canonical Wnt signaling pathway
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
|
19664990
|
|
3,867
|
| 38890 |
Jag2
|
|
increases_quantity of
|
HSC (Kit+Lin-)
|
in coculture; direct cell-to-cell contact is required
|
in vitro
|
| 38923 |
Jag2
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
|
10910909
|
|
3,869
|
| 38920 |
Notch2
|
|
decreases_activity of
|
myeloid cell differentiation
|
|
in vitro
|
| 38925 |
Dll1
|
|
increases_activity of
|
T cell differentiation
|
|
in vitro
|
| 38926 |
Dll1
|
|
interacts (colocalizes) with
|
Notch1
|
|
|
| 38937 |
Notch2
|
|
increases_activity of
|
repopulation >16 weeks
|
under stress conditions
|
in vivo
|
| 38943 |
Notch2
|
|
increases_activity of
|
self-renewal
|
under stress conditions
|
in vivo
|
|
21285514
|
|
3,873
|
| 39038 |
Wnt5a
|
|
increases_activity of
|
Notch signaling pathway
|
in CD127-KSL cells
|
|
|
17881570
|
|
3,876
|
| 39054 |
HSC (SP,KSL)
|
|
increases_activity of
|
Notch signaling pathway
|
in comparison to more differentiated cells
|
in vivo
|
| 39055 |
Notch signaling pathway
|
|
decreases_activity of
|
hematopoietic stem cell differentiation
|
|
in vitro
|
| 39059 |
Notch signaling pathway
|
|
increases_activity of
|
repopulation >16 weeks
|
|
in vivo
|
| 39060 |
canonical Wnt signaling pathway
|
|
increases_activity of
|
Notch signaling pathway
|
|
in vivo
|
|
15665828
|
|
4,089
|
| 42219 |
Satb1
|
|
decreases_expression of
|
Numb
|
in HSC (CD150+CD48-KSL)
|
|
| 42221 |
Numb
|
|
decreases_activity of
|
Notch signaling pathway
|
|
|
| 42232 |
Notch signaling pathway
|
|
increases_expression of
|
Hes1
|
in HSC (CD150+CD48-KSL)
|
|
| 42234 |
Notch signaling pathway
|
|
increases_expression of
|
Hes5
|
in HSC (CD150+CD48-KSL)
|
|
| 42235 |
Notch signaling pathway
|
|
increases_expression of
|
Dtx1
|
in HSC (CD150+CD48-KSL)
|
|
| 42236 |
Notch signaling pathway
|
|
increases_expression of
|
Hey1
|
in HSC (CD150+CD48-KSL)
|
|
| 42270 |
Satb1
|
|
increases_activity of
|
Notch signaling pathway
|
in HSC (CD150+CD48-KSL), by down regulating Numb expression
|
|
|
23563689
|
|
4,281
|
| 43858 |
Jag1
|
|
increases_activity of
|
non-cell autonomous activity
|
|
|
| 43860 |
Jag1
|
|
increases_activity of
|
repopulation >16 weeks
|
if Jag1 is expressed in endothelial cells
|
in vivo
|
| 43870 |
endothelial cell
|
|
increases_expression of
|
Jag1
|
|
|
| 43879 |
HSC (KSL)
|
|
increases_expression of
|
Notch2
|
|
|
| 43885 |
Jag1
|
|
increases_activity of
|
Notch signaling pathway
|
in HSCs, if Jag1 is expressed in endothelial cells
|
|
| 43905 |
Jag1
|
|
increases_activity of
|
quiescence
|
of HSC (CD150+CD48-KSL), if Jag1 is expressed in endothelial cells
|
in vivo
|
| 43907 |
Jag1
|
|
increases_activity of
|
self-renewal
|
if Jag1 is expressed in endothelial cells
|
in vivo
|
| 43908 |
Notch2
|
|
increases_activity of
|
Notch signaling pathway
|
|
|
| 43909 |
Notch2
|
|
interacts (colocalizes) with
|
Jag1
|
|
|
|
24012753
|
HSC