HSCGeneral Information:
| Id: | 2,140 (click here to show other Interactions for entry) |
| Mus musculus | |
| C57Bl/6 female mice, 6 week old | |
| Reference: | Wilson A et al.(2008) Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135: 1118-1129 [PMID: 19062086] |
Interaction Information:
| Comment | Around 70% of the HSC (CD34negLSKCD150+48-) population are in G0 and less than 2% are actively cycling, thus making them the most rare and by far the most quiescent LSK cell type. In contrast, 7-fold more of the CD34+LSK CD150+48- cells (MPP1) are actively cycling, and only 39% are in G0. As expected, MPPs expressing CD48 and CD135 are highly proliferative. [Method: in vitro: cell cycle analysis using Ki67-FITC and DAPI.] |
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Formal Description Interaction-ID: 24260 |
immunophenotype MPP (CD34+CD48+CD150-CD135-KSL) decreases_activity of process |