|
1
|
(HPO:0002189)
|
Excessive daytime sleepiness |
|
|
|
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8 / 7739
|
|
2
|
(HPO:0002494)
|
Abnormal rapid eye movement sleep |
|
|
|
|
4 / 7739
|
|
3
|
(HPO:0002519)
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Hypnagogic hallucinations |
|
|
|
|
3 / 7739
|
|
4
|
(HPO:0006896)
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Hypnopompic hallucinations |
|
|
|
|
2 / 7739
|
|
5
|
(OMIM)
|
Rapid weight gain may occur |
|
|
|
|
1 / 7739
|
|
6
|
(OMIM)
|
Cataplexy, paroxysmal weakness or paralysis |
|
|
|
|
2 / 7739
|
|
7
|
(OMIM)
|
Cataplexy often triggered by strong emotions |
|
|
|
|
2 / 7739
|
|
8
|
(OMIM)
|
Attacks of disabling daytime drowsiness and low alertness |
|
|
|
|
2 / 7739
|
|
9
|
(OMIM)
|
Mean sleep latency is less than 5 to 8 minutes |
|
|
|
|
1 / 7739
|
|
10
|
(OMIM)
|
Sleep paralysis at beginning or end of sleep period (in 60% of patients) |
|
|
|
|
1 / 7739
|
|
11
|
(OMIM)
|
Nocturnal sleep disruption |
|
|
|
|
1 / 7739
|
|
12
|
(OMIM)
|
Milder cases have isolated recurrent daytime sleepiness and/or lapses into sleep without cataplexy |
|
|
|
|
2 / 7739
|
|
13
|
(OMIM)
|
Loss of hypocretin (orexin)-secreting neurons in the hypothalamus |
|
|
|
|
1 / 7739
|
|
14
|
(OMIM)
|
HLA-DQw6 association (DQB1*0602) |
|
|
|
|
1 / 7739
|
|
15
|
(OMIM)
|
Decreased levels of CSF hypocretin (HCRT, 602358) |
|
|
|
|
2 / 7739
|