1
|
(OMIM)
|
Diffuse filling of alveoli with pigmented macrophages |
Very frequent [IBIS]
|
|
23728865; 24524107
|
IBIS
|
2 / 7739
|
2
|
(HPO:0002094)
|
Dyspnea |
Frequent [IBIS]
|
89% (n=103)
|
23728865
|
IBIS
|
132 / 7739
|
3
|
(MedDRA:10065906)
|
Carbon monoxide diffusing capacity decreased |
Frequent [IBIS]
|
86% (n=7)
|
884976
|
IBIS
|
8 / 7739
|
4
|
(HPO:0012418)
|
Hypoxemia |
Frequent [IBIS]
|
85% (n=20)
|
18184268
|
IBIS
|
18 / 7739
|
5
|
(HPO:0003565)
|
Elevated erythrocyte sedimentation rate |
Frequent [IBIS]
|
75% (n=20)
|
18184268
|
IBIS
|
31 / 7739
|
6
|
(OMIM)
|
Radiograph shows ground glass appearance |
Frequent [IBIS]
|
70% (n=20)
|
18184268, 15459629
|
IBIS
|
7 / 7739
|
7
|
(HPO:0012735)
|
Cough |
Frequent [IBIS]
|
70% (n=103)
|
23728865
|
IBIS
|
24 / 7739
|
8
|
(HPO:0002795)
|
Functional respiratory abnormality |
Frequent [IBIS]
|
60% (n=103)
|
23728865
|
IBIS
|
13 / 7739
|
9
|
(HPO:0003237)
|
Increased IgG level |
Frequent [IBIS]
|
59% (n=20)
|
18184268
|
IBIS
|
5 / 7739
|
10
|
(HPO:0003212)
|
Increased IgE level |
Frequent [IBIS]
|
45% (n=20)
|
18184268
|
IBIS
|
13 / 7739
|
11
|
(HPO:0001217)
|
Clubbing |
Frequent [IBIS]
|
40% (n=103)
|
23728865
|
IBIS
|
39 / 7739
|
12
|
(HPO:0002792)
|
Reduced vital capacity |
Frequent [IBIS]
|
40% (n=20)
|
18184268
|
IBIS
|
17 / 7739
|
13
|
(HPO:0000961)
|
Cyanosis |
Frequent [IBIS]
|
28% (n=103)
|
23728865
|
IBIS
|
60 / 7739
|
14
|
(HPO:0002113)
|
Pulmonary infiltrates |
Frequent [IBIS]
|
|
23728865; 6726519; 15653981
|
IBIS
|
36 / 7739
|
15
|
(HPO:0002111)
|
Restrictive deficit on pulmonary function testing |
Frequent [IBIS]
|
|
17043377; 15653981
|
IBIS
|
25 / 7739
|
16
|
(HPO:0100749)
|
Chest pain |
Occasional [IBIS]
|
23% (n=103)
|
23728865
|
IBIS
|
92 / 7739
|
17
|
(HPO:0001824)
|
Weight loss |
Occasional [IBIS]
|
20% (n=103)
|
23728865
|
IBIS
|
42 / 7739
|
18
|
(MedDRA:10025080)
|
Lung consolidation |
Occasional [IBIS]
|
20% (n=20)
|
18184268
|
IBIS
|
5 / 7739
|
19
|
(HPO:0002110)
|
Bronchiectasis |
Occasional [IBIS]
|
12% (n=17)
|
18184268
|
IBIS
|
73 / 7739
|
20
|
(HPO:0001880)
|
Eosinophilia |
Occasional [IBIS]
|
10% (n=20)
|
18184268
|
IBIS
|
35 / 7739
|
21
|
(HPO:0002105)
|
Hemoptysis |
Occasional [IBIS]
|
7% (n=103)
|
23728865
|
IBIS
|
30 / 7739
|
22
|
(HPO:0001648)
|
Cor pulmonale |
Occasional [IBIS]
|
|
5902256
|
IBIS
|
16 / 7739
|
23
|
(OMIM)
|
Obstructive respiratory impairment |
Occasional [IBIS]
|
|
15653981
|
IBIS
|
3 / 7739
|
24
|
(HPO:0001508)
|
Failure to thrive |
|
|
6726519
|
IBIS
|
454 / 7739
|
25
|
(HPO:0002098)
|
Respiratory distress |
|
|
9876799
|
IBIS
|
75 / 7739
|
26
|
(HPO:0002789)
|
Tachypnea |
|
|
3130863
|
IBIS
|
48 / 7739
|
27
|
(HPO:0005942)
|
Desquamative interstitial pneumonitis |
|
|
23728865
|
IBIS
|
3 / 7739
|
28
|
(OMIM)
|
Hyperinflation |
|
|
23775787
|
IBIS
|
1 / 7739
|
29
|
(OMIM)
|
Lung biopsy shows interstitial lymphoplasmocytic inflammation |
|
|
6726519
|
IBIS
|
1 / 7739
|
30
|
(OMIM)
|
Absence of hyaline membranes |
|
|
3130863
|
IBIS
|
1 / 7739
|
31
|
(OMIM)
|
Cough, nonproductive |
|
|
23728865
|
IBIS
|
5 / 7739
|
32
|
(HPO:0012378)
|
Fatigue |
|
|
23728865
|
IBIS
|
50 / 7739
|
33
|
(OMIM)
|
Reduced diffusion capacity |
|
|
23728865
|
IBIS
|
8 / 7739
|
34
|
(HPO:0012415)
|
Abnormal blood gas level |
|
|
23728865
|
IBIS
|
9 / 7739
|
35
|
(HPO:0002207)
|
Diffuse reticular or finely nodular infiltrations |
|
|
24844883
|
IBIS
|
11 / 7739
|
36
|
(HPO:0002206)
|
Pulmonary fibrosis |
|
|
16865368
|
IBIS
|
51 / 7739
|
37
|
(HPO:0006530)
|
Interstitial pulmonary disease |
|
|
23728865; 24424167
|
IBIS
|
26 / 7739
|
38
|
(MedDRA:10062049)
|
Lymphocytic infiltration |
|
|
23728865
|
IBIS
|
9 / 7739
|
39
|
(HPO:0100750)
|
Atelectasis |
|
|
23775787
|
IBIS
|
17 / 7739
|
40
|
(HPO:0002093)
|
Respiratory insufficiency |
|
|
17043377
|
IBIS
|
410 / 7739
|
41
|
(HPO:0002321)
|
Vertigo |
|
|
24524107
|
IBIS
|
58 / 7739
|
42
|
(HPO:0001945)
|
Fever |
|
|
19637809
|
IBIS
|
218 / 7739
|
43
|
(HPO:0002109)
|
Abnormality of the bronchi |
|
|
23728865
|
IBIS
|
6 / 7739
|
44
|
(MedDRA:10067182)
|
Bronchial wall thickening |
|
|
23728865; 24524107
|
IBIS
|
5 / 7739
|