|
1
|
(OMIM)
|
Reduced diffusion capacity |
Very frequent [IBIS]
|
100% (n=27)
|
26100347
|
IBIS
|
8 / 7739
|
|
2
|
(HPO:0002094)
|
Dyspnea |
Very frequent [IBIS]
|
97% (n=33)
|
26100347
|
IBIS
|
132 / 7739
|
|
3
|
(OMIM)
|
Decreased CD4+/CD8+ ratio |
Very frequent [IBIS]
|
96% (n=25)
|
24424167
|
IBIS
|
2 / 7739
|
|
4
|
(HPO:0012735)
|
Cough |
Very frequent [IBIS]
|
94% (n=33)
|
26100347
|
IBIS
|
24 / 7739
|
|
5
|
(MedDRA:10065906)
|
Carbon monoxide diffusing capacity decreased |
Very frequent [IBIS]
|
|
11790668
|
IBIS
|
8 / 7739
|
|
6
|
(HPO:0011991)
|
Abnormal neutrophil cell number |
Frequent [IBIS]
|
89% (n=19)
|
12952254
|
IBIS
|
3 / 7739
|
|
7
|
(HPO:0040088)
|
Abnormal lymphocyte count |
Frequent [IBIS]
|
88% (n=25)
|
26100347
|
IBIS
|
3 / 7739
|
|
8
|
(HPO:0002206)
|
Pulmonary fibrosis |
Frequent [IBIS]
|
87% (n=83)
|
18829672
|
IBIS
|
51 / 7739
|
|
9
|
(HPO:0002111)
|
Restrictive deficit on pulmonary function testing |
Frequent [IBIS]
|
83% (n=30)
|
26100347
|
IBIS
|
25 / 7739
|
|
10
|
(HPO:0003493)
|
Antinuclear antibody positivity |
Frequent [IBIS]
|
76% (n=25)
|
26100347
|
IBIS
|
15 / 7739
|
|
11
|
(HPO:0002110)
|
Bronchiectasis |
Frequent [IBIS]
|
76% (n=33)
|
26100347
|
IBIS
|
73 / 7739
|
|
12
|
(HPO:0002207)
|
Diffuse reticular or finely nodular infiltrations |
Frequent [IBIS]
|
73% (n=33)
|
26100347
|
IBIS
|
11 / 7739
|
|
13
|
(HPO:0002103)
|
Abnormality of the pleura |
Frequent [IBIS]
|
67% (n=33)
|
26100347
|
IBIS
|
58 / 7739
|
|
14
|
(OMIM)
|
Radiograph shows ground glass appearance |
Frequent [IBIS]
|
64% (n=33)
|
26100347
|
IBIS
|
7 / 7739
|
|
15
|
(MedDRA:10025080)
|
Lung consolidation |
Frequent [IBIS]
|
36% (n=33)
|
26100347
|
IBIS
|
5 / 7739
|
|
16
|
(HPO:0001945)
|
Fever |
Occasional [IBIS]
|
27% (n=33)
|
26100347
|
IBIS
|
218 / 7739
|
|
17
|
(OMIM)
|
Sputum production |
Occasional [IBIS]
|
24% (n=33)
|
26100347
|
IBIS
|
3 / 7739
|
|
18
|
(HPO:0002923)
|
Rheumatoid factor positive |
Occasional [IBIS]
|
21% (n=28)
|
26100347
|
IBIS
|
5 / 7739
|
|
19
|
(HPO:0012378)
|
Fatigue |
Occasional [IBIS]
|
12% (n=33)
|
26100347
|
IBIS
|
50 / 7739
|
|
20
|
(HPO:0100749)
|
Chest pain |
Occasional [IBIS]
|
6% (n=33)
|
26100347
|
IBIS
|
92 / 7739
|
|
21
|
(OMIM)
|
Honeycomb fibrosis, varying in age and location |
Occasional [IBIS]
|
|
18829672, 11790668
|
IBIS
|
6 / 7739
|
|
22
|
(HPO:0006530)
|
Interstitial pulmonary disease |
|
|
24424167
|
IBIS
|
26 / 7739
|
|
23
|
(MedDRA:10062049)
|
Lymphocytic infiltration |
|
|
26100347
|
IBIS
|
9 / 7739
|
|
24
|
(HPO:0002090)
|
Pneumonia |
|
|
26100347
|
IBIS
|
59 / 7739
|
|
25
|
(HPO:0002829)
|
Arthralgia |
|
|
26100347
|
IBIS
|
79 / 7739
|
|
26
|
(HPO:0001386)
|
Joint swelling |
|
|
26100347
|
IBIS
|
7 / 7739
|
|
27
|
(HPO:0000988)
|
Skin rash |
|
|
26100347
|
IBIS
|
98 / 7739
|
|
28
|
(OMIM)
|
Raynaud syndrome |
|
|
26100347
|
IBIS
|
3 / 7739
|
|
29
|
(HPO:0012415)
|
Abnormal blood gas level |
|
|
26100347
|
IBIS
|
9 / 7739
|
|
30
|
(HPO:0002792)
|
Reduced vital capacity |
|
|
18829672
|
IBIS
|
17 / 7739
|
|
31
|
(HPO:0002093)
|
Respiratory insufficiency |
|
|
18829672
|
IBIS
|
410 / 7739
|
|
32
|
(HPO:0001824)
|
Weight loss |
|
|
11790668
|
IBIS
|
42 / 7739
|
|
33
|
(HPO:0100759)
|
Clubbing of fingers |
|
|
11790668
|
IBIS
|
40 / 7739
|
|
34
|
(HPO:0002795)
|
Functional respiratory abnormality |
|
|
11790668
|
IBIS
|
13 / 7739
|
|
35
|
(OMIM)
|
Inspiratory crackles (50%) |
|
|
11790668
|
IBIS
|
4 / 7739
|
|
36
|
(HPO:0012418)
|
Hypoxemia |
|
|
11790668
|
IBIS
|
18 / 7739
|
|
37
|
(HPO:0002113)
|
Pulmonary infiltrates |
|
|
11790668
|
IBIS
|
36 / 7739
|
|
38
|
(OMIM)
|
Type II pneumocyte hyperplasia |
|
|
11790668
|
IBIS
|
4 / 7739
|
|
39
|
(HPO:0001640)
|
Cardiomegaly |
|
|
24001730
|
IBIS
|
81 / 7739
|
|
40
|
(HPO:0030166)
|
Night sweats |
|
|
26029588
|
IBIS
|
3 / 7739
|
|
41
|
(HPO:0002109)
|
Abnormality of the bronchi |
|
|
26029588
|
IBIS
|
6 / 7739
|
|
42
|
(HPO:0100598)
|
Pulmonary edema |
|
|
26029588
|
IBIS
|
17 / 7739
|
|
43
|
(HPO:0006515)
|
Interstitial pneumonitis |
|
|
26029588
|
IBIS
|
13 / 7739
|