|
1
|
(HPO:0001939)
|
Abnormality of metabolism/homeostasis |
|
|
|
|
328 / 7739
|
|
2
|
(HPO:0002664)
|
Neoplasm |
|
|
|
|
111 / 7739
|
|
3
|
(OMIM)
|
Association between poor metabolizers (PM) and Parkinson disease |
|
|
|
|
1 / 7739
|
|
4
|
(OMIM)
|
PMs show impaired metabolism of debrisoquine and related drugs |
|
|
|
|
1 / 7739
|
|
5
|
(OMIM)
|
PMs show increased sensitivity to effects of medication |
|
|
|
|
1 / 7739
|
|
6
|
(OMIM)
|
Statistical association of extensive metabolism (EM, wildtype) and malignancy, especially smoking-induced lung cancer |
|
|
|
|
1 / 7739
|
|
7
|
(OMIM)
|
PMs show deficient oxidation of debrisoquine |
|
|
|
|
1 / 7739
|
|
8
|
(OMIM)
|
PMs show decreased levels of hepatic CYP2D6 enzyme |
|
|
|
|
1 / 7739
|
|
9
|
(OMIM)
|
PMs excrete 10 to 200 times less metabolite in urine than wildtype (EM) |
|
|
|
|
1 / 7739
|
|
10
|
(OMIM)
|
PMs have increased metabolic ratio of unchanged drug-to-metabolite in urine |
|
|
|
|
1 / 7739
|
|
11
|
(HPO:0000007)
|
Autosomal recessive inheritance |
|
|
|
|
2538 / 7739
|