LYMPHOMA, HODGKIN, CLASSIC

General Information (adopted from Orphanet):

Synonyms, Signs: HODGKIN DISEASE
Number of Symptoms 3
OrphanetNr:
OMIM Id: 236000
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal recessive inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0003459) Polyclonal elevation of IgM 4 / 7739
2
(HPO:0012189) Hodgkin lymphoma 5 / 7739
3
(HPO:0003347) Impaired lymphocyte transformation with phytohemagglutinin 6 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM Manigand et al. (1964) described a brother and sister with Hodgkin disease and reviewed the literature on familial occurrence. In familial cases Vianna et al. (1974) found that the time-intervals between diagnoses were shorter than the age differences. ...
Molecular genetics OMIM In a family with the nodular sclerosis type of classic Hodgkin lymphoma in which affected individuals carried a t(2,3)(q11.2;p21.31) translocation that disrupted the KLHDC8B gene, Salipante et al. (2009) found that family members with the translocation expressed only ...
Population genetics OMIM Ferraris et al. (1997) quoted an estimate of 4.5% as the proportion of all cases of Hodgkin disease represented by familial Hodgkin disease. They reviewed 28 articles on familial Hodgkin disease, published between 1972 and 1995, with detailed ...