Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer (Ramoz et al., 2000). EV results from an abnormal susceptibility to specific related human papillomavirus (HPV) genotypes and to the oncogenic potential of ... Epidermodysplasia verruciformis (EV) is a rare genodermatosis associated with a high risk of skin cancer (Ramoz et al., 2000). EV results from an abnormal susceptibility to specific related human papillomavirus (HPV) genotypes and to the oncogenic potential of some of them, mainly HPV5. Infection with EV-associated HPV leads to the early development of disseminated flat wart-like and pityriasis versicolor-like lesions. Patients are unable to reject their lesions, and cutaneous Bowen carcinomas in situ and invasive squamous cell carcinomas develop in about half of them, mainly on sun-exposed areas.
The lesions often resemble verrucae planae (Sullivan and Ellis, 1939). The mucous membranes, hair, and nails are not affected. Malignant degeneration, usually of the superficial basal cell type, is frequent. Characteristic changes in the epidermal cells with peculiar ... The lesions often resemble verrucae planae (Sullivan and Ellis, 1939). The mucous membranes, hair, and nails are not affected. Malignant degeneration, usually of the superficial basal cell type, is frequent. Characteristic changes in the epidermal cells with peculiar vacuolization are observed. Ellis (1953) stated that this disorder occurs most frequently in Orientals.
Ramoz et al. (2002) studied 2 Algerian and 2 Colombian consanguineous families who had been previously described (Ramoz et al., 1999; Ramoz et al., 2000) and an additional EV1-linked Algerian family in which an individual was affected with ... Ramoz et al. (2002) studied 2 Algerian and 2 Colombian consanguineous families who had been previously described (Ramoz et al., 1999; Ramoz et al., 2000) and an additional EV1-linked Algerian family in which an individual was affected with HPV5. The EV1 locus (605828) had been mapped to a 1-cM interval on 17q25 (Ramoz et al., 2000); Ramoz et al. (2002) cloned both the EVER1 and EVER2 genes from this region. In individuals with epidermodysplasia verruciformis, Ramoz et al. (2002) identified 2 homozygous nonsense mutations in the EVER1 gene (605828.0001-605828.0002) and 2 homozygous mutations in the EVER2 gene (605829.0001-605829.0002).