DIABETES MELLITUS, INSULIN-DEPENDENT

General Information (adopted from Orphanet):

Synonyms, Signs: INSULIN-DEPENDENT DIABETES MELLITUS 1, INCLUDED
JOD DIABETES MELLITUS, INSULIN-DEPENDENT, 1, INCLUDED
DIABETES MELLITUS, TYPE I
JUVENILE-ONSET DIABETES
IDDM1, INCLUDED
IDDM
Number of Symptoms 13
OrphanetNr:
OMIM Id: 222100
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Heterogeneous
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000103) Polyuria 60 / 7739
2
(HPO:0001959) Polydipsia 43 / 7739
3
(HPO:0002591) Polyphagia 25 / 7739
4
(HPO:0000819) Diabetes mellitus 131 / 7739
5
(HPO:0003074) Hyperglycemia 37 / 7739
6
(HPO:0001993) Ketoacidosis 17 / 7739
7
(HPO:0002715) Abnormality of the immune system 46 / 7739
8
(OMIM) Abnormally increased gluconeogenesis 1 / 7739
9
(OMIM) Insufficient glucose disposal 1 / 7739
10
(OMIM) Pancreatic autoimmunity 1 / 7739
11
(OMIM) Relative insulin deficiency 1 / 7739
12
(OMIM) Hyperglycemia-induced osmotic diuresis 1 / 7739
13
(HPO:0001425) Heterogeneous 132 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) The type of diabetes mellitus called IDDM is a disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. It is a genetically heterogeneous autoimmune disease affecting about 0.3% of Caucasian ...
Clinical Description OMIM The term diabetes mellitus is not precisely defined and the lack of a consensus on diagnostic criteria has made its genetic analysis difficult. Diabetes mellitus is classified clinically into 2 major forms of the primary illness, insulin-dependent diabetes ...
Molecular genetics OMIM Todd et al. (1987) estimated that more than half of the inherited predisposition to IDDM maps to the region of the HLA class II genes on chromosome 6. Analysis of the DNA sequences from diabetics indicated that alleles ...
Population genetics OMIM IDDM occurs about 20 times more frequently among children in the United States than among those in China. Bao et al. (1989) examined the question of whether this was due to a difference in the frequency of the ...