Alopecia-mental retardation syndrome (APMR) is a rare autosomal recessive disorder in which affected individuals show loss of hair on the scalp, absence of eyebrows, eyelashes, and axillary and pubic hair, and mild to severe mental retardation (summary by ... Alopecia-mental retardation syndrome (APMR) is a rare autosomal recessive disorder in which affected individuals show loss of hair on the scalp, absence of eyebrows, eyelashes, and axillary and pubic hair, and mild to severe mental retardation (summary by Wali et al., 2007). - Genetic Heterogeneity of Alopecia-Mental Retardation Syndrome Additional loci for alopecia-mental retardation syndrome have been mapped to chromosome 3q26.2-q26.31 (APMR2; 610422) and chromosome 18q11.2-q12.2 (APMR3; 613930).
Baraitser et al. (1983) reported the combination of alopecia from birth and mental retardation in 3 cousins, each in a different sibship of an inbred Middle Eastern family. The alopecia was total and involved all areas of normal ... Baraitser et al. (1983) reported the combination of alopecia from birth and mental retardation in 3 cousins, each in a different sibship of an inbred Middle Eastern family. The alopecia was total and involved all areas of normal hair growth. Mental retardation was severe. A similar condition was described by Perniola et al. (1980) in 2 sibs of consanguineous parents. Both sibs were deaf. Benke and Hajianpour (1985) described an inbred Pakistani family in which 3 consanguineous couples had a child with this combination. Hearing, teeth, nails, bone x-rays, and sweating were normal and the patients were not dysmorphic. The Amish hair-brain syndrome (234050) has mild mental retardation and associated short stature; the affected persons have hair which is brittle and falls out.