WOLFF-PARKINSON-WHITE SYNDROME

General Information (adopted from Orphanet):

Synonyms, Signs: ACCESSORY ATRIOVENTRICULAR PATHWAYS, INCLUDED
WPW SYNDROME PREEXCITATION SYNDROME, INCLUDED
Number of Symptoms 15
OrphanetNr:
OMIM Id: 194200
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0001645) Sudden cardiac death 84 / 7739
2
(HPO:0001638) Cardiomyopathy 192 / 7739
3
(HPO:0001962) Palpitations 62 / 7739
4
(HPO:0006684) Ventricular preexcitation with multiple accessory pathways 1 / 7739
5
(HPO:0001716) Wolff-Parkinson-White syndrome 21 / 7739
6
(HPO:0004757) Paroxysmal atrial fibrillation 16 / 7739
7
(HPO:0004309) Ventricular preexcitation 6 / 7739
8
(HPO:0004763) Paroxysmal supraventricular tachycardia 10 / 7739
9
(HPO:0001297) Stroke 44 / 7739
10
(HPO:0005165) Shortened PR interval 9 / 7739
11
(HPO:0006677) Prolonged QRS complex 16 / 7739
12
(OMIM) Higher incidence of multiple accessory pathways 1 / 7739
13
(OMIM) Short PR interval and prolonged QRS, with slurred-up stroke of the R wave (delta wave) on EKG 1 / 7739
14
(OMIM) Familial cardiomyopathy 1 / 7739
15
(OMIM) Possible increased risk of sudden cardiac death 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Clinical Description OMIM The features of this electrocardiographic syndrome are short PR interval and prolonged QRS, specifically with a slurred-up stroke of the R wave called a delta wave. The patients are prone to paroxysmal supraventricular tachycardia. The familial occurrence of ...
Molecular genetics OMIM Gollob et al. (2001) noted that the PRKAG2 gene is located in the critical genomic region of the WPW syndrome locus identified by linkage on chromosome 7q34-q36. In affected members of 2 families with WPW syndrome, they identified ...
Population genetics OMIM The WPW syndrome is the second most common cause of paroxysmal supraventricular tachycardia in most parts of the world and is the most common cause in China, being responsible for more than 70% of cases (Wan et al., ...