VESICOURETERAL REFLUX 1

General Information (adopted from Orphanet):

Synonyms, Signs: VUR1
VUR
Number of Symptoms 3
OrphanetNr:
OMIM Id: 193000
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance:
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0000076) Vesicoureteral reflux 94 / 7739
2
(OMIM) Detection by radionuclide voiding cystography 1 / 7739
3
(OMIM) Progressive renal damage if untreated 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Vesicoureteral reflux (VUR) is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys. It is a risk factor for urinary tract infections. Primary VUR results from a developmental defect of ...
Clinical Description OMIM Mulcahy et al. (1970) described a high familial incidence. The disorder is rare in blacks. Burger (1972) found 23 families with 2 or more affected first-degree relatives and added 7 more containing a total of 20 affected first-degree ...
Molecular genetics OMIM Choi et al. (1998) studied 23 affected individuals from 8 families with primary familial VUR. Sanyanusin et al. (1995) demonstrated mutations in the PAX2 gene (167409.0001) in renal coloboma syndrome (120330), of which VUR is a part. By ...
Population genetics OMIM Lu et al. (2007) stated that VUR has an incidence of approximately 1 in 100 infants.

Reflux nephropathy resulting from vesicoureteral reflux is said to account for as much as 15% of end-stage renal disease in ...