TREMOR, HEREDITARY ESSENTIAL, 1

General Information (adopted from Orphanet):

Synonyms, Signs: TREMOR, FAMILIAL ESSENTIAL, 1
FET1
ETM1
Number of Symptoms 7
OrphanetNr:
OMIM Id: 190300
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0002345) Action tremor 11 / 7739
2
(HPO:0002378) Hand tremor 9 / 7739
3
(HPO:0001260) Dysarthria 329 / 7739
4
(HPO:0002174) Postural tremor 22 / 7739
5
(HPO:0003676) Progressive disorder 148 / 7739
6
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739
7
(OMIM) Fine rapid hand tremor, 4-12 Hz 1 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) Dominantly inherited essential tremor was recognized by Dana (1887). It may be the most common human movement disorder. The main feature of essential tremor is postural tremor of the arms, but the head, legs, trunk, voice, jaw, and ...
Clinical Description OMIM Louis (2001) reviewed the clinical features of essential tremor and therapeutic options.

Critchley (1949) gave a classic review of this subject. Larsson and Sjogren (1960) did a thorough study of hereditary essential tremor in a parish ...

Molecular genetics OMIM In 23 of 30 unrelated French families, Lucotte et al. (2006) found significant association between hereditary essential tremor and a BalI polymorphism in the DRD3 gene (S9G; 126451.0001) on chromosome 3q13. Parametric linkage analysis and transmission disequilibrium testing ...
Population genetics OMIM Rautakorpi et al. (1982) reported a remarkably high frequency of essential tremor in a Finnish population: 55.5% of persons over 40 years of age.

Benito-Leon et al. (2005) estimated an annual incidence of essential tremor of ...