ABELSON MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1

General Information (adopted from Orphanet):

Synonyms, Signs: ABELSON STRAIN OF MURINE LEUKEMIA VIRUS
ABL1/NUP214 FUSION GENE, INCLUDED
TRANSFORMATION GENE: ONCOGENE ABL
ABL ABL1/BCR FUSION GENE, INCLUDED
ABL1
Number of Symptoms 3
OrphanetNr:
OMIM Id: 189980
ICD-10:
UMLs:
MeSH:
MedDRA:
Snomed:

Prevalence, inheritance and age of onset:

Prevalence: No data available.
Inheritance: Autosomal dominant inheritance
[Omim]
Age of onset:

Disease classification (adopted from Orphanet):

Parent Diseases: No data available.

Symptom Information: Sort by abundance 

1
(HPO:0005506) Chronic myelogenous leukemia 3 / 7739
2
(HPO:0001939) Abnormality of metabolism/homeostasis 328 / 7739
3
(HPO:0000006) Autosomal dominant inheritance 2518 / 7739

Associated genes:

ClinVar (via SNiPA)

Gene symbol Variation Clinical significance Reference

Additional Information:

Description: (OMIM) The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Alterations of ABL1 by chromosomal rearrangement or viral transduction lead to ...
Molecular genetics OMIM - Resistance to Tyrosine Kinase Inhibitors

Clinical studies with the Abl tyrosine kinase inhibitor STI571 in CML demonstrated that many patients with advanced-stage disease respond initially but then relapse. Through biochemical and molecular analysis of clinical ...